IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells

Oncotarget

Volumn 8, Issue 23, 2017, Pages 36936-36949

  Battula, Venkata Lokesh ^a   Nguyen, Khoa ^a   Sun, Jeff ^a   Pitner, Mary Kathryn ^a   Yuan, Bin ^a   Bartholomeusz, Chandra ^a   Hail, Numsen ^a   Andreeff, Michael ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Breast cancer; Cancer stem cells; GD2; GD3 synthase; NF B

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; 4(2'-AMINOETHYL)AMINO-1,8-DIMETHYLIMIDAZO(1,2-A)QUINOXALINE; ALPHA-N-ACETYLNEURAMINATE ALPHA-2,8-SIALYLTRANSFERASE; GANGLIOSIDE; GANGLIOSIDE, GD2; IMIDAZOLE DERIVATIVE; QUINOXALINE DERIVATIVE; SIALYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER CELL LINE; BREAST TUMOR; CANCER STEM CELL; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METASTATIC BREAST CANCER; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR VOLUME; ANIMAL; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; METASTASIS; NONOBESE DIABETIC MOUSE; PATHOLOGY; RNA INTERFERENCE; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARCINOGENESIS; CELL LINE, TUMOR; GANGLIOSIDES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; IMIDAZOLES; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; QUINOXALINES; RNA INTERFERENCE; SIALYLTRANSFERASES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85020190996     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16294     Document Type: Article

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