Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells

Analytical Chemistry

Volumn 89, Issue 3, 2017, Pages 1689-1696

  Zhu, Min ^a   Fang, Jinzhang ^a   Zhang, Jingjing ^a   Zhang, Zheng ^a   Xie, Jianhui ^a   Yu, Yan ^a   Ruan, Jennifer Jin ^b   Chen, Zhao ^a   Hou, Wei ^a   Yang, Gensheng ^a   Su, Weike ^a   Ruan, Benfang Helen ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b Hangzhou Jennifer Biotech Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; DISEASES; SYNTHETIC APERTURE RADAR;

ANTICANCER ACTIVITIES; BIOMOLECULAR INTERACTIONS; CELL-BASED ASSAYS; DETECTION METHODS; GLUTAMATE DEHYDROGENASE; KINETIC BINDING; MITOCHONDRIAL FUNCTION; SYNTHETIC COMPOUNDS;

ASSAYS;

EBSELEN; ENZYME INHIBITOR; GLUTAMATE DEHYDROGENASE; GLUTAMINASE; ORGANOSELENIUM DERIVATIVE; PYRROLE DERIVATIVE; RECOMBINANT PROTEIN;

ALLOSTERIC SITE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECT; ENZYME ASSAY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ALLOSTERIC SITE; AZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ASSAYS; ENZYME INHIBITORS; GLUTAMATE DEHYDROGENASE; GLUTAMINASE; HUMANS; KINETICS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; ORGANOSELENIUM COMPOUNDS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85026732299     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.6b03849     Document Type: Article

References (24)

1. Ward, P. S.; Thompson, C. B. Cancer Cell 2012, 21, 297-308 10.1016/j.ccr.2012.02.014
2. Altman, B. J.; Stine, Z. E.; Dang, C. V. Nat. Rev. Cancer 2016, 16, 619-634 10.1038/nrc.2016.71
3. Cooper, A. J.; Shurubor, Y. I.; Dorai, T.; Pinto, J. T.; Isakova, E. P.; Deryabina, Y. I.; Denton, T. T.; Krasnikov, B. F. Amino Acids 2016, 48, 1-20 10.1007/s00726-015-2061-7
4. Moreadith, R. W.; Lehninger, A. L. J. Biol. Chem. 1984, 259, 6215-6221
5. Hanahan, D.; Weinberg, R. A. Cell 2011, 144, 646-674 10.1016/j.cell.2011.02.013
6. Cassago, A.; Ferreira, A. P.; Ferreira, I. M.; Fornezari, C.; Gomes, E. R.; Greene, K. S.; Pereira, H. M.; Garratt, R. C.; Dias, S. M.; Ambrosio, A. L. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 1092-1097 10.1073/pnas.1112495109
7. Ferreira, A. P.; Cassago, A.; Gonçalves, K. A.; Dias, M. M.; Adamoski, D.; Ascençao, C. F.; Honorato, R. V.; de Oliveira, J. F.; Ferreira, I. M.; Fornezari, C.; Bettini, J.; Oliveira, P. S.; Paes Leme, A. F.; Portugal, R. V.; Ambrosio, A. L.; Dias, S. M. J. Biol. Chem. 2013, 288, 28009-28020 10.1074/jbc.M113.501346
8. Cairns, R. A.; Harris, I. S.; Mak, T. W. Nat. Rev. Cancer 2011, 11, 85-95 10.1038/nrc2981
9. Lukey, M. J.; Katt, W. P.; Cerione, R. A. Drug Discovery Today 2016, 10.1016/j.drudis.2016.12.003
10. Katt, W. P.; Ramachandran, S.; Erickson, J. W.; Cerione, R. A. Mol. Cancer Ther. 2012, 11, 1269-1278 10.1158/1535-7163.MCT-11-0942
11. Elgogary, A.; Xu, Q.; Poore, B.; Alt, J.; Zimmermann, S. C.; Zhao, L.; Fu, J.; Chen, B.; Xia, S.; Liu, Y.; Neisser, M.; Nguyen, C.; Lee, R.; Park, J. K.; Reyes, J.; Hartung, T.; Rojas, C.; Rais, R.; Tsukamoto, T.; Semenza, G. L.; Hanes, J.; Slusher, B. S.; Le, A. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, E5328-5336 10.1073/pnas.1611406113
12. Gross, M. I.; Demo, S. D.; Dennison, J. B.; Chen, L.; Chernov-Rogan, T.; Goyal, B.; Janes, J. R.; Laidig, G. J.; Lewis, E. R.; Li, J.; Mackinnon, A. L.; Parlati, F.; Rodriguez, M. L.; Shwonek, P. J.; Sjogren, E. B.; Stanton, T. F.; Wang, T.; Yang, J.; Zhao, F.; Bennett, M. K. Mol. Cancer Ther. 2014, 13, 890-901 10.1158/1535-7163.MCT-13-0870
13. Thomas, A. G.; Rojas, C.; Tanega, C.; Shen, M.; Simeonov, A.; Boxer, M. B.; Auld, D. S.; Ferraris, D. V.; Tsukamoto, T.; Slusher, B. S. Biochem. Biophys. Res. Commun. 2013, 438, 243-248 10.1016/j.bbrc.2013.06.110
14. McElroy, K. E.; Bouchard, P. J.; Harpel, M. R.; Horiuchi, K. Y.; Rogers, K. C.; Murphy, D. J.; Chung, T. D.; Copeland, R. A. Anal. Biochem. 2000, 284, 382-387 10.1006/abio.2000.4740
15. Zhang, W.; Zhu, M.; Wang, F.; Cao, D.; Ruan, J. J.; Su, W.; Ruan, B. H. Anal. Biochem. 2016, 509, 33-40 10.1016/j.ab.2016.06.026
16. Shi, H.; Liu, S.; Miyake, M.; Liu, K. J. Chem. Res. Toxicol. 2006, 19, 655-660 10.1021/tx0502544
17. Masaki, C.; Sharpley, A. L.; Godlewska, B. R.; Berrington, A.; Hashimoto, T.; Singh, N.; Vasudevan, S. R.; Emir, U. E.; Churchill, G. C.; Cowen, P. J. Psychopharmacology (Berl) 2016, 233, 1097-1104 10.1007/s00213-015-4189-2
18. He, J.; Li, D.; Xiong, K.; Ge, Y.; Jin, H.; Zhang, G.; Hong, M.; Tian, Y.; Yin, J.; Zeng, H. Bioorg. Med. Chem. 2012, 20, 3816-3827 10.1016/j.bmc.2012.04.033
19. Björnstedt, M.; Kumar, S.; Björkhem, L.; Spyrou, G.; Holmgren, A. Biomed. Environ. Sci. 1997, 10, 271-279
20. Fischer, H.; Dereu, N. Bull. Soc. Chim. Belg. 1987, 96, 757-768 10.1002/bscb.19870961006
21. Hartwick, E. W.; Curthoys, N. P. J. Enzyme Inhib. Med. Chem. 2012, 27, 861-867 10.3109/14756366.2011.622272
22. Thangavelu, K.; Pan, C. Q.; Karlberg, T.; Balaji, G.; Uttamchandani, M.; Suresh, V.; Schüler, H.; Low, B. C.; Sivaraman, J. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 7705-7710 10.1073/pnas.1116573109
23. DeLaBarre, B.; Gross, S.; Fang, C.; Gao, Y.; Jha, A.; Jiang, F.; Song, J. J.; Wei, W.; Hurov, J. B. Biochemistry 2011, 50, 10764-10770 10.1021/bi201613d
24. Zhang, J.; Wang, G.; Mao, Q.; Li, S.; Xiong, W.; Lin, Y.; Ge, J. Oncotarget 2016, 295, 799-800 10.18632/Oncotarget 7657