Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 21, 2016, Pages 5254-5259

  Węglarz Tomczak, Ewelina ^a   Burda Grabowska, Małgorzata ^a   Giurg, Mirosław ^a   Mucha, Artur ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Angiogenesis; Binding mode; Metalloaminopeptidases; Organoselenium compounds; Structure activity relationship

Indexed keywords

2,2' DICARBAMOYLDIARYL DISELENIDE DERIVATIVE; AMINOPEPTIDASE INHIBITOR; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BENZISOSELENAZOL 3(2H) ONE DERIVATIVE; CYTOPROTECTIVE AGENT; EBSELEN; METHIONYL AMINOPEPTIDASE 2; UNCLASSIFIED DRUG; AMINOPEPTIDASE; METALLOPROTEINASE; ORGANOSELENIUM DERIVATIVE; PROTEINASE INHIBITOR; PYRROLE DERIVATIVE;

ACYLATION; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; DIAZOTIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGENATION; IC50; MOLECULAR MODEL; PROTEIN TARGETING; PROTON TRANSPORT; STEADY STATE; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN;

AMINOPEPTIDASES; AZOLES; HUMANS; INHIBITORY CONCENTRATION 50; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; ORGANOSELENIUM COMPOUNDS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84994060575     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.09.050     Document Type: Article

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