Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6799-6804

  Wiget, Paul A ^a   Manzano, Lawrence A ^a   Pruet, Jeff M ^a   Gao, Grace ^a   Saito, Ryota ^a   Monzingo, Arthur F ^a   Jasheway, Karl R ^a   Robertus, Jon D ^a   Anslyn, Eric V ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Dipeptide mimic; Pterin; Ricin inhibitors; RTA; SAR; Thioamide

Indexed keywords

7 AMINOAMIDOPTERIN DERIVATIVE; DIPEPTIDE DERIVATIVE; GLYCYLPHENYLALANINE; N [N (PTERIN 7 YL)CARBONYLGLYCYL)PHENYLALANINE; PTERIN DERIVATIVE; RICIN; RICIN A; SULFUR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; REACTION ANALYSIS; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; PROTEIN BINDING; PTERINS; RICIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; THIOAMIDES; THIOUREA;

EID: 84888879527     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.017     Document Type: Article

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