Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

Cell Reports

Volumn 23, Issue 9, 2018, Pages 2617-2628

  Zhang, Jimmy ^a   Wang, Yves T ^a   Miller, James H ^a   Day, Mary M ^a   Munger, Joshua C ^a   Brookes, Paul S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

complex II; heart; ischemia; mitochondria; reperfusion; succinate

Indexed keywords

2 OXOGLUTARIC ACID; AMINOTRANSFERASE; DIMETHYL ALPHA KETOGLUTARIC ACID; GLYCOGEN; STABLE ISOTOPE; SUCCINATE COENZYME A LIGASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; UNCLASSIFIED DRUG; ASPARTIC ACID; REACTIVE OXYGEN METABOLITE;

ANAPLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CARDIAC MUSCLE CELL; CELL HYPOXIA; CHEMICAL REACTION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; MALE; METABOLOMICS; MITOCHONDRION; MOUSE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; ANIMAL; AUTOPHAGY; C57BL MOUSE; ENERGY METABOLISM; GLYCOGENOLYSIS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; REPERFUSION INJURY;

ANIMALS; ASPARTIC ACID; AUTOPHAGY; CITRIC ACID CYCLE; ELECTRON TRANSPORT COMPLEX II; ENERGY METABOLISM; GLYCOGENOLYSIS; GLYCOLYSIS; MALE; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SUCCINIC ACID; TRANSAMINASES;

EID: 85047479235     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.04.104     Document Type: Article

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