The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 1, 2016, Pages H29-H38

  Zhang, Jimmy ^a   Nadtochiy, Sergiy M ^a   Urciuoli, William R ^a   Brookes, Paul S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

8 hydroxyquinoline; Heart; Ischemia; Mitophagy; Uncoupling

Indexed keywords

CHLOROQUINE; CLOXIQUINE; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; UNCLASSIFIED DRUG; HYBRID PROTEIN; PROTECTIVE AGENT; UNCOUPLING PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; HEART INFARCTION SIZE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PROTECTION; IN VIVO STUDY; ISOLATED HEART; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE CELL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; TIME FACTOR;

ANIMALS; AUTOPHAGY; CHLOROQUINE; CHLOROQUINOLINOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GREEN FLUORESCENT PROTEINS; ISOLATED HEART PREPARATION; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTECTIVE AGENTS; RECOMBINANT FUSION PROTEINS; TIME FACTORS; UNCOUPLING AGENTS;

EID: 84953266676     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00926.2014     Document Type: Article

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