Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation

Journal of Molecular and Cellular Cardiology

Volumn 88, Issue , 2015, Pages 64-72

  Nadtochiy, Sergiy M ^a   Urciuoli, William ^a   Zhang, Jimmy ^a   Schafer, Xenia ^a   Munger, Joshua ^a   Brookes, Paul S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Fatty acids; Glucose; Ischemia; Preconditioning; Reperfusion; Sirtuin

Indexed keywords

2 HYDROXYGLUTARIC ACID; AMINO ACID; CARBON 13; FATTY ACID; GLUCOSE; GLUTATHIONE; GLYCOGEN; SIRTUIN 1; ALPHA-HYDROXYGLUTARATE; GLUTARIC ACID DERIVATIVE; NAPHTHALENE DERIVATIVE; PYRONE DERIVATIVE; SIRT1 PROTEIN, MOUSE; SPLITOMICIN;

ADULT; AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EX VIVO STUDY; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HEART FUNCTION; HEART MUSCLE METABOLISM; HEART PROTECTION; IN VIVO STUDY; ISCHEMIC PRECONDITIONING; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ADAPTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CARDIAC MUSCLE; CELL RESPIRATION; GENE EXPRESSION; GENETICS; HEART INFARCTION PREVENTION; KNOCKOUT MOUSE; METABOLISM; METABOLOME; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS;

ADAPTATION, PHYSIOLOGICAL; AMINO ACIDS; ANIMALS; CELL RESPIRATION; FATTY ACIDS; GENE EXPRESSION; GLUTARATES; GLUTATHIONE; GLYCOGEN; GLYCOLYSIS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; METABOLOME; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NAPHTHALENES; ORGAN CULTURE TECHNIQUES; PRINCIPAL COMPONENT ANALYSIS; PYRONES; SIRTUIN 1;

EID: 84942543819     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.09.008     Document Type: Article

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