Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection

Cardiovascular Research

Volumn 88, Issue 2, 2010, Pages 257-266

  Støttrup, Nicolaj Brejnholt ^a,b   Løfgren, Bo ^a,b   Birkler, Rune Dupont ^b   Nielsen, Jan Møller ^a,b   Wang, Lixing ^c   Caldarone, Christopher Anthony ^c   Kristiansen, Steen Buus ^a,b   Contractor, Hussain ^d   Johannsen, Mogens ^b   Bøtker, Hans Erik ^a,b   Nielsen, Torsten Toftegaard ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Carbohydrate metabolism; Infarct size; Ischaemia; Malate aspartate shuttle; Reperfusion

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOOXYACETIC ACID; ASPARTIC ACID; GLYCOGEN; LACTIC ACID; MALIC ACID; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRICARBOXYLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISCHEMIC PRECONDITIONING; ISOLATED HEART; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RABBIT; RAT; REPERFUSION INJURY;

AMINOOXYACETIC ACID; ANIMALS; ASPARTIC ACID; CARDIOTONIC AGENTS; CELL RESPIRATION; ENERGY METABOLISM; GLUCOSE; HEMODYNAMICS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALATES; MALE; MICRODIALYSIS; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PERFUSION; RABBITS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 77958096415     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq205     Document Type: Article

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