TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8

FASEB Journal

Volumn 30, Issue 5, 2016, Pages 1823-1835

  Spanjer, Anita I R ^a,f   Baarsma, Hoeke A ^b   Oostenbrink, Lisette M ^b   Jansen, Sepp R ^a,f   Kuipers, Christine C ^a,f   Lindner, Michael ^c   Postma, Dirkje S ^d,f   Meurs, Herman ^a,f   Heijink, Irene H ^d,e,f   Gosens, K Reinoud ^a,e   Königshoff, Melanie ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

^d Department of Pulmonology ^*  (Germany)

^e Experimental Pulmonology and Inflammation Research   (Germany)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Airway remodeling; Extracellular matrix; Myofibroblast differentiation; Wnt signaling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; FRIZZLED 8; FRIZZLED PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VERSICAN; WNT5A PROTEIN; WNT5B PROTEIN; CELL SURFACE RECEPTOR; FRIZZLED 8 PROTEIN, MOUSE; FZD8 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; SMAD3 PROTEIN, HUMAN; WNT PROTEIN; WNT5B PROTEIN, HUMAN;

ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE; WNT SIGNALING PATHWAY; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; KNOCKOUT MOUSE; LUNG; METABOLISM; MOUSE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; LUNG; MICE; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEINS; WNT-5A PROTEIN;

EID: 84966373487     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201500129     Document Type: Article

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