Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Härmä, Ville ^a,b   Schukov, Hannu Pekka ^a,b   Happonen, Antti ^c   Ahonen, Ilmari ^d   Virtanen, Johannes ^a,b   Siitari, Harri ^a   Åkerfelt, Malin ^a,b   Lötjönen, Jyrki ^a   Nees, Matthias ^a,b  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b TURKU CENTRE FOR BIOTECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; LATRUNCULIN A; NARCICLASINE; PACLITAXEL; RAC PROTEIN;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; AUTOMATION; BREAST CANCER CELL LINE; CELL ASSAY; CELL CULTURE; CELL DIFFERENTIATION; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CELL SHAPE; CELL SIZE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESPONSE; IMAGE ANALYSIS; IMAGE PROCESSING; INTRACELLULAR SIGNALING; MORPHOMETRICS; PHENOTYPE; PROSTATE CANCER CELL LINE; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING; TUMOR INVASION; CELL MOTION; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; PROCEDURES; TUMOR CELL LINE;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED;

EID: 84901501094     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096426     Document Type: Article

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