Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 17, 2018, Pages E3950-E3958

  Ahmed, Lucky ^a   Zhang, Yuetian ^b   Block, Eric ^c   Buehl, Michael ^d   Corr, Michael J ^d   Cormanich, Rodrigo A ^e   Gundala, Sivaji ^c   Matsunami, Hiroaki ^f,g   O’Hagan, David ^d   Ozbil, Mehmet ^a   Pan, Yi ^b   Sekharan, Sivakumar ^a   Ten, Nicholas ^a   Wang, Mingan ^h   Yang, Mingyan ^d,h   Zhang, Qingzhi ^d   Zhang, Ruina ^b   Batista, Victor S ^a   Zhuang, Hanyi ^b  

^a YALE UNIVERSITY   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c STATE UNIVERSITY OF NEW YORK   (United States)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e UNIVERSITY OF CAMPINAS   (Brazil)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Molecular dynamics; Musk; Odorant receptor; Olfaction; Quantum mechanics

Indexed keywords

CYCLOALKANE DERIVATIVE; MUSCONE; OR1A1 PROTEIN, HUMAN;

CHEMICAL PHENOMENA; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR MODEL; OLFACTORY RECEPTOR; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

CYCLOPARAFFINS; HEK293 CELLS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ODORANT;

EID: 85045918539     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1713026115     Document Type: Article

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