Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: Role of SAPK/JNK pathway

Biomedicine and Pharmacotherapy

Volumn 102, Issue , 2018, Pages 1084-1091

  Hassanin, Kamel M A ^a   Mahmoud, Mohamed O ^b   Hassan, Hossam M ^b   Abdel Razik, Abdel Razik H ^c   Aziz, Lourin N ^b   Rateb, Mostafa E ^b,d  

^a Minia University   (Egypt)

^b Beni Suef University   (Egypt)

^c Beni Suef University   (Egypt)

^d UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

Author keywords

Apoptosis; Balanites aegyptiaca; Diabetes; Oxidative stress; SAPK JNK pathway

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; BALANITES AEGYPTIACA EXTRACT; BUTANOL; CATALASE; DICHLOROMETHANE; GLICLAZIDE; GLUCOSE TRANSPORTER 4; GLUTATHIONE; HEMOGLOBIN A1C; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LACTIC ACID; LIPID; MALONALDEHYDE; SAPONIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE DISMUTASE; GLYCOSYLATED HEMOGLOBIN; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID BLOOD LEVEL; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BALANITES; BLOOD; CHEMISTRY; DIET RESTRICTION; DRUG EFFECT; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; LIQUID CHROMATOGRAPHY; MAPK SIGNALING; MASS SPECTROMETRY; METABOLISM; PATHOLOGY; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; APOPTOSIS; BALANITES; BLOOD GLUCOSE; CHROMATOGRAPHY, LIQUID; DIABETES MELLITUS, EXPERIMENTAL; FASTING; GLUCOSE TRANSPORTER TYPE 4; GLYCATED HEMOGLOBIN A; INSULIN; LACTIC ACID; LIPIDS; MALE; MAP KINASE SIGNALING SYSTEM; MASS SPECTROMETRY; MUSCLE, SKELETAL; PANCREAS; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 85044923943     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2018.03.167     Document Type: Article

References (42)

1. Chen, L., Magliano, D.J., Zimmet, P.Z., The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nat. Rev. Endocrinol. 8 (2011), 228–236, 10.1038/nrendo.2011.183.
2. Qaseem, A., Barry, M.J., Humphrey, L.L., Forciea, M.A., Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline update from the American College of physicians. Ann. Intern. Med., 166(279), 2017, 10.7326/M16-1860.
3. Rains, J.L., Jain, S.K., Oxidative stress, insulin signaling, and diabetes. Free Radical Biol. Med. 50 (2011), 567–575, 10.1016/j.freeradbiomed.2010.12.006.
4. Taka-aki, Kaneto, Yoshihisa, Matsuoka, Kawamori, Nakatani Dan, Miyatsuka, Takeshi, Matsuhisa, Munehide, Yoshimitsu Yamasaki, H., Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J. Mol. Med. 83 (2005), 429–439, 10.1007/s00109-005-0640-x.
5. Grunberger, G., Should Side effects influence the selection of antidiabetic therapies in type 2 diabetes?. Curr. Diab. Rep., 17(21), 2017, 10.1007/s11892-017-0853-8.
6. Gad, M., El-Sawalhi, M., Ismail, M., Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites. Mol. Cell. Biochem. 281 (2006), 173–183, 10.1007/s11010-006-0996-4.
7. Chothani, D.L., Vaghasiya, H.U., A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity. Pharmacognosy Reviews 5 (2011), 55–62, 10.4103/0973-7847.79100.
8. Coskun, O., Kanter, M., Korkmaz, A., Oter, S., Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and? -cell damage in rat pancreas. Pharmacol. Res. 51 (2005), 117–123, 10.1016/j.phrs.2004.06.002.
9. Bhandari, U., kanojia, R., Pillai, K.K., Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J. Ethnopharmacol. 97 (2005), 227–230, 10.1016/j.jep.2004.11.011.
10. Bancroft, J., Gamble, M., Theory and Practice of Histological Techniques. 2008, Churchill Livingstone/Elsevier https://books.google.com.eg/books?hl=en&lr=&id=Dhn2KispfdQC&oi=fnd&pg=PR13&dq=Bancroft+J,+Gamble+M+(2008)+Theory+and+practice+of+histological+techniques.+&ots=JAiHhwNDDd&sig=ZCSHfXvaxPy-skXnFxYTCJ60d&redir_esc=y#v=onepage&q&f=false.
11. Gibson-Corley, K.N., Olivier, A.K., Meyerholz, D.K., Principles for valid histopathologic scoring in research. Vet. Pathol. 50 (2013), 1007–1015, 10.1177/0300985813485099.
12. Ezzat, S.M., Abdel Motaal, A., El Awdan, S.A.W., In vitro and in vivo antidiabetic potential of extracts and a furostanol saponin from Balanites aegyptiaca. Pharmaceutical Biology 55 (2017), 1931–1936, 10.1080/13880209.2017.1343358.
13. Rashad, H., Metwally, F.M., Ezzat, S.M., et al. Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites. Pharmaceutical Biology 55 (2017), 1954–1961, 10.1080/13880209.2017.1354388.
14. Speroni, E., Cervellati, R., Innocenti, G., et al. Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptiaca (L.) Delile. J. Ethnopharmacol. 98 (2005), 117–125, 10.1016/j.jep.2005.01.007.
15. Son, I.S., Kim, J.H., Sohn, H.Y., et al. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed. rats. Biosci. Biotechnol. Biochem. 71 (2007), 3063–3071, 10.1271/bbb.70472.
16. Tharaheswari, M., Jayachandra Reddy, N., Kumar, R., et al. Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in the pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats. Mol. Cell. Biochem. 396 (2014), 161–174, 10.1007/s11010-014-2152-x.
17. Kalailingam, P., Kannaian, B., Tamilmani, E., Kaliaperumal, R., Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine 21 (2014), 1154–1161, 10.1016/j.phymed.2014.04.005.
18. Alexander-Lindo, R.L., Morrison, E.Y.S.A., Nair, M.G., Hypoglycaemic effect of stigmast-4-en-3-one and its corresponding alcohol from the bark of Anacardium occidentale(cashew). Phytother. Res. 18 (2004), 403–407, 10.1002/ptr.1459.
19. Farid, H., Haslinger, E., Kunert, O., Wegner, C., New steroidal glycosides from balanites aegyptiaca. Helvetica Chimica Acta, 85(4), 2002, 1019, 10.1002/1522-2675(200204)85:4<1019::AID-HLCA1019>3.0.CO;2-S.
20. Farag, M.A., Porzel, A., Wessjohann, L.A., Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR. J. Pharm. Biomed. Anal. 115 (2015), 383–387, 10.1016/j.jpba.2015.08.003.
21. Eleazu, C., Okafor, P., Ifeoma, I., Biochemical basis of the use of cocoyam (Colocassia esculenta L.) in the dietary management of diabetes and its complications in streptozotocin induced diabetes in. Asian Pac. J. Trop. Dis. 4:4 (2014), S705–S711, 10.1016/S2222-1808(14)60711-8.
22. Tahara, A., Kurosaki, E., Yokono, M., et al. Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats. J. Pharm. Pharmacol. 66 (2014), 975–987, 10.1111/jphp.12223.
23. Thapa, S.D., SR, K.C., Gautam, S., Gyawali, D., Dyslipidemia in type 2 Diabetes mellitus. J. Pathol. Nepal 7 (2017), 1149–1154, 10.3126/JPN.V7I2.17978.
24. Forbes, J.M., Cooper, M.E., Mechanisms of diabetic complications. Physiol. Rev. 93 (2013), 137–188, 10.1152/physrev.00045.2011.
25. Brøns, C., Grunnet, L.G., Mechanisms in endocrinology: skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?. Eur. J. Endocrinol. 176 (2017), R67–R78, 10.1530/EJE-16-0488.
26. Bakir, B., Erdağ, D., Yildiz, S.E., et al. Immunohistochemical examination on the effects of malathion and Onosma nigricaule (Boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in renal tissues of mice. Ankara Üniv Vet Fak Derg 64 (2017), 125–130.
27. Ugochukwu, N., Babady, N., Antioxidant effects of Gongronema latifolium in hepatocytes of rat models of non-insulin dependent diabetes mellitus. Fitoterapia73 7–8 (2002), 612–618 http://www.ncbi.nlm.nih.gov/pubmed/12490219.
28. Ravi, K., Ramachandran, B., Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin-induced diabetic rats. Biol. Pharm. Bull. 27:8 (2004), 1212–1217 http://www.ncbi.nlm.nih.gov/pubmed/15305024.
29. Das, K., Roychoudhury, A., Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants. Front. Environ. Sci., 2014, 10.3389/fenvs.2014.00053.
30. Valko, M., Leibfritz, D., Moncol, J., Cronin, M., Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39:1 (2007), 44–84, 10.1016/j.biocel.2006.07.001.
31. Çelik, N., Vurmaz, A., Kahraman, A., Protective effect of quercetin on homocysteine-induced oxidative stress. Nutrition 33:January (2017), 291–296, 10.1016/j.nut.2016.07.014.
32. Solinas, G., Karin, M., JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction. FASEB J. 24:8 (2010), 2596–2611, 10.1096/fj.09-151340.
33. Pepin, E., Higa, A., Schuster-Klein, C., et al. Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions. PLoS One, 9, 2014, e112714, 10.1371/journal.pone.0112714.
34. Yuan, J., Yankner, B.A., Fanger, G.R., et al. Apoptosis in the nervous system. Nature 407 (2000), 802–809, 10.1038/35037739.
35. Dickson, L.M., Pancreatic -cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?. AJP: Endocrinol. Metabol. 287 (2004), E192–E198, 10.1152/ajpendo.00031.2004.
36. Eckstein, S.S., Weigert, C., Lehmann, R., Divergent roles of IRS (insulin receptor substrate) 1 and 2 in liver and skeletal muscle. Curr. Med. Chem., 2017, 10.2174/0929867324666170426142826.
37. Kelleher, A., Fairchild, T., Keslacy, S., STZ-induced skeletal muscle atrophy is associated with increased p65 content and downregulation of insulin pathway without NF-κB canonical cascade activation. Acta Diabetol. 47:4 (2010), 315–323, 10.1007/s00592-010-0209-1.
38. Taylor, R., Insulin resistance and type 2 diabetes. Diabetes 61:4 (2012), 778–779, 10.2337/db12-0073 American Diabetes Association:.
39. Leto, D., Saltiel, A., Regulation of glucose transport by insulin: traffic control of GLUT4. Nature reviews. Mol. Cell. Biol. 13:6 (2012), 383–396, 10.1038/nrm3351.
40. DeFronzo R, Tripathy D (2009) Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes care 32 Suppl 2 (Suppl 2). American Diabetes Association:S157-63. doi:10.2337/dc09-S302.
41. Vijayakumar, M., Ajay, A., Bhat, M., Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time. J. Biosci. 35:4 (2010), 525–531 http://www.ncbi.nlm.nih.gov/pubmed/21289434.
42. Saltiel, A., Kahn, C., Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 2001 https://www.nature.com/articles/414799a.