Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 115, Issue , 2015, Pages 383-387

  Farag, Mohamed A ^a   Porzel, Andrea ^b   Wessjohann, Ludger A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

Author keywords

Alkaloid; Antidiabetic natural product; Balanites aegyptiaca; NMR fingerprinting; Trigonelline

Indexed keywords

BALANITES AEGYPTIACA EXTRACT; EPICATECHIN; EPICATECHIN O GLUCOSIDE; FLAVONOID; ISORHAMNETIN; ISORHAMNETIN 3 O GLUCOSIDE; ISORHAMNETIN 3 O RUTINOSIDE; QUERCETIN; RUTOSIDE; TRIGONELLINE; UNCLASSIFIED DRUG; ALKALOID; ANTIDIABETIC AGENT; PLANT EXTRACT;

ANALYTIC METHOD; ARTICLE; BALANITES; BALANITES AEGYPTIACA; BITTER TASTE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; FRUIT; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; MASS SPECTROMETRY; METABOLITE FINGERPRINTING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; LIQUID CHROMATOGRAPHY; METABOLOMICS; PROCEDURES; STANDARD; STANDARDS; TASTE;

ALKALOIDS; BALANITES; CHROMATOGRAPHY, LIQUID; FRUIT; HYPOGLYCEMIC AGENTS; MASS SPECTROMETRY; METABOLOMICS; MOLECULAR STRUCTURE; PLANT EXTRACTS; PROTON MAGNETIC RESONANCE SPECTROSCOPY; REFERENCE STANDARDS; TASTE;

EID: 84939143672     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.08.003     Document Type: Article

References (20)

1. Farag M.A., Wessjohann L.A. Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics. Planta Med. 2012, 78:488-496.
2. van der Kooy F., Maltese F., Choi Y.H., Kim H.K., Verpoorte R. Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting. Planta Med. 2009, 75:763-775.
3. Kim H.K., Choi Y.H., Verpoorte R. NMR-based metabolomic analysis of plants. Nat. Prot. 2010, 5:536-549.
4. Farag M.A., Mahrous E.A., Luebken T., Porzel A., Wessjohann L. Classification of commercial cultivars of Humulus lupulus L. (hop) by chemometric pixel analysis of two dimensional nuclear magnetic resonance spectra. Metabolomics 2014, 10:21-32.
5. Schroeder F.C., Gibson D.M., Churchill A.C.L., Sojikul P., Wursthorn E.J., Krasnoff S.B., Clardy J. Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew. Chem. Int. Ed. 2007, 46:901-904.
6. Liang Y.S., Kim H.K., Lefeber A.W.M., Erkelens C., Choi Y.H., Verpoorte R. Identification of phenylpropanoids in methyl jasmonate treated Brassica rapa leaves using two-dimensional nuclear magnetic resonance spectroscopy. J. Chromatogr. A 2006, 1112:148-155.
7. Mohamed A.H., Eltahir K.E.H., Ali M.B., Galal M., Ayeed I.A., Adam S.I., Hamid O.A. Some pharmacological and toxicological studies on Balanites aegyptiaca bark. Phytother. Res. 1999, 13:439-441.
8. Kamel M.S., Ohtani K., Kurokawa T., Assaf M.H., Elshanawany M.A., Ali A.A., Kasai R., Ishibashi S., Tanaka O. Studies on Balanites-aegyptiaca fruits, an antidiabetic Egyptian folk medicine. Chem. Pharm. Bull. 1991, 39:1229-1233.
9. Farid H., Haslinger E., Kunert O., Wegner C., Hamburger M. New steroidal glycosides from Balanites aegyptiaca. Helv. Chim. Acta 2002, 85:1019-1026.
10. El Tahir A., Ibrahim A.M., Satti G.M.H., Theander T.G., Kharazmi A., Khalid S.A. The potential antileishmanial activity of some Sudanese medicinal plants. Phytother. Res. 1998, 12:576-579.
11. Gad M.Z., El-Sawalhi M.M., Ismail M.F., El-Tanbouly N.D. Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites. Mol. Cell. Biochem. 2006, 281:173-183.
12. Abdel Motaal A., El-Askary H., Crockett S., Kunert O., Sakr B., Shaker S., Grigore A., Albulescu R., Bauer R. Phytomedicine 2015, 22:829-836.
13. Meda R.N.T., Vlase L., Lamien-Meda A., Lamien C.E., Muntean D., Tiperciuc B., Oniga I., Nacoulma O.G. Identification and quantification of phenolic compounds from Balanites aegyptiaca (L.) Del (Balanitaceae) galls and leaves by HPLC-MS. Nat. Prod. Res. 2011, 25:93-99.
14. Sarker S.D., Bartholomew B., Nash R.J. Alkaloids from Balanites aegyptiaca. Fitoterapia 2000, 71:328-330.
15. AlMourabit A., Pusset M., Chtourou M., Gaigne C., Ahond A., Poupat C., Potier P. Pyraxinine, a novel nitrogenous compound from the marine sponge Cymbastela cantharella. J. Nat. Prod. 1997, 60:290-291.
16. Yoshinari O., Sato H., Igarashi K. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci. Biotechnol. Biochem. 2009, 73:1033-1041.
17. Yoshinari O., Takenake A., Igarashi K. Trigonelline ameliorates oxidative stress in type 2 diabetic Goto-Kakizaki rats. J. Med. Food 2013, 16:34-41.
18. Amaro C.A.B., Gonzalez-Cortazar M., Herrera-Ruiz M., Roman-Ramos R., Aguilar-Santamaria L., Tortoriello J., Jimenez-Ferrer E. Hypoglycemic and hypotensive activity of a root extract of smilax aristolochiifolia, standardized on N-trans-feruloyl-tyramine. Molecules 2014, 19:11366-11384.
19. del Campo G., Berregi I., Caracena R., Zuriarrain J. Quantitative determination of caffeine, formic acid, trigonelline and 5-(hydroxymethyl) furfural in soluble coffees by H-1 NMR spectrometry. Talanta 2010, 81:367-371.
20. Satheeshkumar N., Mukherjee P.K., Bhadra S., Saha B.P. Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L. and its constituents. Phytomedicine 2010, 17:292-295.