In vitro and in vivo antidiabetic potential of extracts and a furostanol saponin from Balanites aegyptiaca

Pharmaceutical Biology

Volumn 55, Issue 1, 2017, Pages 1931-1936

  Ezzat, Shahira Mohammed ^a   Motaal, Amira Abdel ^a   El Awdan, Sally Abdel Wanees ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

C peptides; Desert date; Diabetic complications; Insulin; Pregnanes

Indexed keywords

26 (O BETA DEXTRO GLUCOPYRANOSYL) 22 O METHYLFUROST 5 ENE 3BETA,26 DIOL 3 O BETA DEXTRO GLUCOPYRANOSYL (1-4) [ALPHA LEVO RHAMNOPYRANOSYL (1-2)] BETA DEXTRO GLUCOPYRANOSIDE; ALDEHYDE REDUCTASE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; BALANITES AEGYPTIACA EXTRACT; C PEPTIDE; CHOLESTEROL; GLICLAZIDE; GLUCOSE; INSULIN; METHANOL; PREGN 5 ENE 3BETA,16BETA,20 TRIO 1 3 O BETA DEXTRO GLUCOPYRANOSIDE; PREGNANE DERIVATIVE; SAPONIN; STIGMASTEROL; STIGMASTEROL 3 O BETA DEXTRO GLUCOPYRANOSIDE; UNCLASSIFIED DRUG; FUROSTANOL SAPONIN I; PLANT EXTRACT; STEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BALANITES; BALANITES AEGYPTIACA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC COMPLICATION; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; FRACTIONATION; FRUIT; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; NONHUMAN; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WISTAR RAT; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; ISOLATION AND PURIFICATION; METABOLISM; MOUSE;

ANIMALS; BALANITES; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FRUIT; HYPOGLYCEMIC AGENTS; MALE; MICE; PLANT EXTRACTS; RATS; RATS, WISTAR; SAPONINS; STEROLS;

EID: 85027533635     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880209.2017.1343358     Document Type: Article

References (29)

1. Abdel Motaal A, El-Askary H, Crockett S, Kunert O, Sakr B, Shaker S, Grigore A, Albulescu R, Bauer R. 2015. Aldose reductase inhibition of a saponin-rich fraction and new furostanol saponin derivatives from Balanites aegyptiaca. Phytomedicine. 22:829-836.
2. Agrawal PK, Jain DC, Gupta RK, Thakur RS. 1985. Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry. 24:2479-2496.
3. Brosky G, Logothetopoulos J. 1969. Streptozotocin diabetes in the mouse and Guinea pig. Diabetes. 18:606-611.
4. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. 1974. Enzymatic determination of total serum cholesterol. Clin Chem. 20:470-475.
5. Campbell LK, White JR, Campbell RK. 1996. Acarbose: its role in the treatment of diabetes mellitus. Ann Pharmacother. 30:1255-1262.
6. Cheyne GA, Gilmore EA. 1973. Stability of the blood glucose colour complex with 4-aminophenazone as oxygen acceptor. Med Lab Technol. 30:191-192.
7. Chothani DL, Vaghasiya HU. 2011. A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity. Phcog Rev. 5:55-62.
8. Fossati P, Prencipe L. 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 28:2077-2080.
9. Guzmán Á, Guerrero RO. 2005. Inhibition of aldose reductase by herbs extracts and natural substances and their role in prevention of cataracts. Rev Cubana Plant Med. 10:3-4.
10. Hara S, Okabe H, Mihashi K. 1987. Gas-liquid chromatographic separation of aldose enantiomers as trimethylsilyl ethers of methyl 2-(polyhydroxyalkyl)-thiazolidine-4(R)-carboxylates. Chem Pharm Bull. 35:501-506.
11. Hosny M, Khalifa T, Calis I, Wright AD, Sticher O. 1992. Balanitoside, a furostanol glycoside, and 6-methyldiosgenin from Balanites aegyptiaca. Phytochemistry. 31:3565-3569.
12. Jackson JE, Bressler R. 1981. Clinical pharmacology of sulphonylurea hypoglycaemic agents: part 1. Drugs. 22:211-245.
13. Juárez-Rojop IE, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY. 2012. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 12:236.
14. Judzewitsch RG, Pfeifer MA, Best JD, Beard JC, Halter JB, Porte D Jr. 1982. Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal and stimulated insulin secretion by increasing islet sensitivity to glucose. J Clin Endocrinol Metab. 55:321-328.
15. Kamel MS. 1998. A furostanol saponin from fruits of Balanites aegyptiaca. Phytochemistry. 48:755-757.
16. Kamel MS, Koskinen A. 1995. Pregnane glycosides from fruits of Balanites aegyptiaca. Phytochemistry. 40:1773-1775.
17. King AJ. 2012. The use of animal models in diabetes research. Br J Pharmacol. 166:877-894.
18. Li H, Song F, Xing J, Tsao R, Liu Z, Liu S. 2009. Screening and structural characterization of a-glucosidase inhibitors from Hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS. J Am Soc Mass Spectrom. 20:1496-1503.
19. Matsui T, Tanaka T, Tamura S, Toshima A, Tamaya K, Miyata Y, Tanaka K, Matsumoto K. 2007. alpha-Glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem. 55:99-105.
20. Motaal AA, Shaker S, Haddad PS. 2012. Antidiabetic activity of standardized extracts of Balanites aegyptiaca fruits using cell-based bioassays. Phcog J. 4:20-24.
21. Murugan P, Pari L. 2006. Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide-induced diabetic rats. Basic Clin Pharmacol Toxicol. 99:122-127.
22. Nishimura C, Yamaoka T, Mizutani M, Yamashita K, Akera T, Tanimoto T. 1991. Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system. Biochim Biophys Acta. 1078:171-178.
23. Patel MB, Mishra SM. 2009. Aldose reductase inhibitory activity of a C-glycosidic flavonoid derived from Enicostemma hyssopifolium. J Complement Integr Med. 6:1.
24. Rajalingam R, Srinivasan N, Govindarajulu P. 1993. Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats. Indian J Exp Biol. 31:577-579.
25. Ridhay A, Noor A, Soekamto NH, Harlim T, van Altena I. 2012. A stigmasterol glycoside from the root wood of Melochia umbellata (Houtt) Stapf var. degrabrata K. Indones J Chem. 12:100-103.
26. Robinson KM, Begovic ME, Rhinehart BL, Heineke EW, Ducep JB, Kastner PR, Marshall FN, Danzin C. 1991. New potent alpha-glucohydrolase inhibitor MDL 73945 with long duration of action in rats. Diabetes. 40:825-830.
27. Sheetz MJ, King GL. 2002. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 288:2579-2588.
28. Shirwaikar A, Rajendran K, Punitha IS. 2005. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J Ethnopharmacol. 97:369-374.
29. Yabe-Nishimura C. 1998. Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacol Rev. 50:21-33.