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Volumn 178, Issue 4, 2018, Pages R127-R139

Diabetic cardiomyopathy: Pathophysiology and potential metabolic interventions state of the art review

Author keywords

[No Author keywords available]

Indexed keywords

DIABETIC CARDIOMYOPATHY; ENERGY METABOLISM; HEART FUNCTION; HEART MUSCLE METABOLISM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STEATOSIS; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

EID: 85044760864     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-17-0724     Document Type: Review
Times cited : (58)

References (129)
  • 1
    • 84936772024 scopus 로고    scopus 로고
    • updated May, Geneva: World Health Organization
    • WHO. Fact sheet no 310; the top 10 causes of death. updated May 2014. Geneva: World Health Organization. (available at: http://www. who.int/mediacentre/factsheets/fs310/en/)
    • (2014) Fact Sheet No 310; the Top 10 Causes of Death
  • 2
    • 0015968924 scopus 로고
    • Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study
    • Garcia MJ, McNamara PM, Gordon T & Kannel WB. Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes 1974 23 105-111. (https://doi.org/10.2337/ diab.23.2.105)
    • (1974) Diabetes , vol.23 , pp. 105-111
    • Garcia, M.J.1    McNamara, P.M.2    Gordon, T.3    Kannel, W.B.4
  • 3
    • 3342886026 scopus 로고    scopus 로고
    • The incidence of congestive heart failure in type 2 diabetes: An update
    • Nichols GA, Gullion CM, Koro CE, Ephross SA & Brown JB. The incidence of congestive heart failure in type 2 diabetes: an update. Diabetes Care 2004 27 1879-1884. (https://doi.org/10.2337/ diacare.27.8.1879)
    • (2004) Diabetes Care , vol.27 , pp. 1879-1884
    • Nichols, G.A.1    Gullion, C.M.2    Koro, C.E.3    Ephross, S.A.4    Brown, J.B.5
  • 4
    • 0034844049 scopus 로고    scopus 로고
    • Mortality and causes of death in the WHO multinational study of vascular disease in diabetes
    • Morrish JN, Wang S-L, Stevens KL, Fuller HJ & Keen H. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia 2001 44 S14-S21. (https://doi.org/10.1007/ PL00002934)
    • (2001) Diabetologia , vol.44 , pp. S14-S21
    • Morrish, J.N.1    Wang, S.-L.2    Stevens, K.L.3    Fuller, H.J.4    Keen, H.5
  • 10
    • 0001486358 scopus 로고
    • Asthma and diabetes mellitus
    • Leyden E. Asthma and diabetes mellitus. Zeutschr Klin Med 1881 3 358-364.
    • (1881) Zeutschr Klin Med , vol.3 , pp. 358-364
    • Leyden, E.1
  • 12
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease: The framingham study
    • Kannel WB & McGee DL. Diabetes and cardiovascular disease: the framingham study. JAMA 1979 241 2035-2038. (https://doi. org/10.1001/jama.1979.03290450033020)
    • (1979) JAMA , vol.241 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 13
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial
    • Hansson L, Zanchetti A, Carruthers SG, Dahlöf B, Elmfeldt D, Julius S, Ménard J, Rahn KH, Wedel H & Westerling S. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998 351 1755-1762. (https://doi.org/10.1016/S0140-6736(98)04311-6)
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3    Dahlöf, B.4    Elmfeldt, D.5    Julius, S.6    Ménard, J.7    Rahn, K.H.8    Wedel, H.9    Westerling, S.10
  • 14
    • 79953730275 scopus 로고    scopus 로고
    • The comorbidities of diabetes and hypertension: Mechanisms and approach to target organ protection
    • Long AN & Dagogo-Jack S. The comorbidities of diabetes and hypertension: mechanisms and approach to target organ protection. Journal of Clinical Hypertension 2011 13 244-251. (https://doi. org/10.1111/j.1751-7176.2011.00434.x)
    • (2011) Journal of Clinical Hypertension , vol.13 , pp. 244-251
    • Long, A.N.1    Dagogo-Jack, S.2
  • 15
    • 84942918197 scopus 로고    scopus 로고
    • Cardiac structure and function across the glycemic spectrum in elderly men and women free of prevalent heart disease: The atherosclerosis risk in the community study
    • Skali H, Shah A, Gupta DK, Cheng S, Claggett B, Liu J, Bello N, Aguilar D, Vardeny O, Matsushita K et al. Cardiac structure and function across the glycemic spectrum in elderly men and women free of prevalent heart disease: the atherosclerosis risk in the community study. Circulation: Heart Failure 2015 8 448-454.
    • (2015) Circulation: Heart Failure , vol.8 , pp. 448-454
    • Skali, H.1    Shah, A.2    Gupta, D.K.3    Cheng, S.4    Claggett, B.5    Liu, J.6    Bello, N.7    Aguilar, D.8    Vardeny, O.9    Matsushita, K.10
  • 19
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part I: General concepts
    • Taegtmeyer H, McNulty P & Young ME. Adaptation and maladaptation of the heart in diabetes: part I: general concepts. Circulation 2002 105 1727-1733. (https://doi.org/10.1161/01. CIR.0000012466.50373.E8)
    • (2002) Circulation , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 22
    • 84986916245 scopus 로고    scopus 로고
    • Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: A multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms
    • Khan JN, Wilmot EG, Leggate M, Singh A, Yates T, Nimmo M, Khunti K, Horsfield MA, Biglands J, Clarysse P et al. Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms. European Heart Journal - Cardiovascular Imaging 2014 15 1263-1269. (https://doi. org/10.1093/ehjci/jeu121)
    • (2014) European Heart Journal - Cardiovascular Imaging , vol.15 , pp. 1263-1269
    • Khan, J.N.1    Wilmot, E.G.2    Leggate, M.3    Singh, A.4    Yates, T.5    Nimmo, M.6    Khunti, K.7    Horsfield, M.A.8    Biglands, J.9    Clarysse, P.10
  • 27
    • 1842529750 scopus 로고    scopus 로고
    • Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
    • Boyer JK, Thanigaraj S, Schechtman KB & Pérez JE. Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus. American Journal of Cardiology 2004 93 870-875. (https://doi.org/10.1016/j.amjcard.2003.12.026)
    • (2004) American Journal of Cardiology , vol.93 , pp. 870-875
    • Boyer, J.K.1    Thanigaraj, S.2    Schechtman, K.B.3    Pérez, J.E.4
  • 29
    • 74049125911 scopus 로고    scopus 로고
    • The development of heart failure in patients with diabetes mellitus and preclinical diastolic dysfunction: A population based study
    • From AM, Scott CG & Chen HH. The development of heart failure in patients with diabetes mellitus and preclinical diastolic dysfunction: a population based study. Journal of the American College of Cardiology 2010 55 300-305. (https://doi.org/10.1016/j.jacc.2009.12.003)
    • (2010) Journal of the American College of Cardiology , vol.55 , pp. 300-305
    • From, A.M.1    Scott, C.G.2    Chen, H.H.3
  • 31
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - An engine out of fuel
    • Neubauer S. The failing heart - an engine out of fuel. New England Journal of Medicine 2007 356 1140-1151. (https://doi.org/10.1056/ NEJMra063052)
    • (2007) New England Journal of Medicine , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 33
    • 0028033268 scopus 로고
    • The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
    • Gulick T, Cresci S, Caira T, Moore DD & Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. PNAS 1994 91 11012-11016. (https://doi.org/10.1073/pnas.91.23.11012)
    • (1994) PNAS , vol.91 , pp. 11012-11016
    • Gulick, T.1    Cresci, S.2    Caira, T.3    Moore, D.D.4    Kelly, D.P.5
  • 36
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • How O-J, Aasum E, Severson DL, Chan WYA, Essop MF & Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 2006 55 466-473. (https://doi.org/10.2337/ diabetes.55.02.06.db05-1164)
    • (2006) Diabetes , vol.55 , pp. 466-473
    • How, O.-J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.A.4    Essop, M.F.5    Larsen, T.S.6
  • 37
    • 0018862072 scopus 로고
    • Utilization of energy-providing substrates in the isolated working rat heart
    • Taegtmeyer H, Hems R & Krebs HA. Utilization of energy-providing substrates in the isolated working rat heart. Biochemical Journal 1980 186 701-711. (https://doi.org/10.1042/bj1860701)
    • (1980) Biochemical Journal , vol.186 , pp. 701-711
    • Taegtmeyer, H.1    Hems, R.2    Krebs, H.A.3
  • 40
    • 0020033858 scopus 로고
    • Decreased insulin binding, glucose transport, and glucose metabolism in soleus muscle of rats fed a high fat diet
    • Grundleger ML & Thenen SW. Decreased insulin binding, glucose transport, and glucose metabolism in soleus muscle of rats fed a high fat diet. Diabetes 1982 31 232-237. (https://doi.org/10.2337/ diab.31.3.232)
    • (1982) Diabetes , vol.31 , pp. 232-237
    • Grundleger, M.L.1    Thenen, S.W.2
  • 41
    • 0036278903 scopus 로고    scopus 로고
    • Metabolic abnormalities in the diabetic heart
    • Lopaschuk G. Metabolic abnormalities in the diabetic heart. Heart Failure Reviews 2002 7 149-159. (https://doi. org/10.1023/A:1015328625394)
    • (2002) Heart Failure Reviews , vol.7 , pp. 149-159
    • Lopaschuk, G.1
  • 43
    • 33749321945 scopus 로고    scopus 로고
    • Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    • An D & Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. American Journal of Physiology - Heart and Circulatory Physiology 2006 291 H1489-H1506. (https://doi.org/10.1152/ajpheart.00278.2006)
    • (2006) American Journal of Physiology - Heart and Circulatory Physiology , vol.291 , pp. H1489-H1506
    • An, D.1    Rodrigues, B.2
  • 45
    • 0037315085 scopus 로고    scopus 로고
    • Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    • Aasum E, Hafstad AD, Severson DL & Larsen TS. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 2003 52 434-441. (https://doi. org/10.2337/diabetes.52.2.434)
    • (2003) Diabetes , vol.52 , pp. 434-441
    • Aasum, E.1    Hafstad, A.D.2    Severson, D.L.3    Larsen, T.S.4
  • 46
    • 4344601004 scopus 로고    scopus 로고
    • Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts
    • Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S & Abel ED. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 2004 53 2366-2374. (https://doi.org/10.2337/ diabetes.53.9.2366)
    • (2004) Diabetes , vol.53 , pp. 2366-2374
    • Mazumder, P.K.1    O'Neill, B.T.2    Roberts, M.W.3    Buchanan, J.4    Yun, U.J.5    Cooksey, R.C.6    Boudina, S.7    Abel, E.D.8
  • 48
    • 33744969160 scopus 로고    scopus 로고
    • The determination of the redox states and phosphorylation potential in living tissues and their relationship to metabolic control of disease phenotypes
    • Veech RL. The determination of the redox states and phosphorylation potential in living tissues and their relationship to metabolic control of disease phenotypes. Biochemistry and Molecular Biology Education 2006 34 168-179. (https://doi.org/10.1002/ bmb.2006.49403403168)
    • (2006) Biochemistry and Molecular Biology Education , vol.34 , pp. 168-179
    • Veech, R.L.1
  • 49
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2004 70 309-319. (https://doi.org/10.1016/j.plefa.2003.09.007)
    • (2004) Prostaglandins, Leukotrienes, and Essential Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 51
    • 3342967512 scopus 로고    scopus 로고
    • Is the failing heart energy starved? on using chemical energy to support cardiac function
    • Ingwall JS & Weiss RG. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circulation Research 2004 95 135-145. (https://doi.org/10.1161/01. RES.0000137170.41939.d9)
    • (2004) Circulation Research , vol.95 , pp. 135-145
    • Ingwall, J.S.1    Weiss, R.G.2
  • 52
    • 0035832045 scopus 로고    scopus 로고
    • Risk factors for congestive heart failure in us men and women: Nhanes i epidemiologic follow-up study
    • He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C & Whelton PK. Risk factors for congestive heart failure in us men and women: Nhanes i epidemiologic follow-up study. Archives of Internal Medicine 2001 161 996-1002. (https://doi.org/10.1001/archinte.161.7.996)
    • (2001) Archives of Internal Medicine , vol.161 , pp. 996-1002
    • He, J.1    Ogden, L.G.2    Bazzano, L.A.3    Vupputuri, S.4    Loria, C.5    Whelton, P.K.6
  • 53
    • 77955354610 scopus 로고    scopus 로고
    • The association of hemoglobin A1c with incident heart failure among people without diabetes: The atherosclerosis risk in communities study
    • Matsushita K, Blecker S, Pazin-Filho A, Bertoni A, Chang PP, Coresh J & Selvin E. The association of hemoglobin A1c with incident heart failure among people without diabetes: the atherosclerosis risk in communities study. Diabetes 2010 59 2020-2026. (https://doi. org/10.2337/db10-0165)
    • (2010) Diabetes , vol.59 , pp. 2020-2026
    • Matsushita, K.1    Blecker, S.2    Pazin-Filho, A.3    Bertoni, A.4    Chang, P.P.5    Coresh, J.6    Selvin, E.7
  • 54
    • 84864970211 scopus 로고    scopus 로고
    • Glycosylated hemoglobin in relationship to cardiovascular outcomes and death in patients with type 2 diabetes: A systematic review and meta-analysis
    • Zhang Y, Hu G, Yuan Z & Chen L. Glycosylated hemoglobin in relationship to cardiovascular outcomes and death in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS ONE 2012 7 e42551.
    • (2012) PLoS ONE , vol.7 , pp. e42551
    • Zhang, Y.1    Hu, G.2    Yuan, Z.3    Chen, L.4
  • 55
    • 14644406822 scopus 로고    scopus 로고
    • Blood glucose and heart failure in nondiabetic patients
    • Nielson C & Lange T. Blood glucose and heart failure in nondiabetic patients. Diabetes Care 2005 28 607.
    • (2005) Diabetes Care , vol.28 , pp. 607
    • Nielson, C.1    Lange, T.2
  • 56
    • 84928699536 scopus 로고    scopus 로고
    • Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: A meta-analysis of randomised controlled trials
    • Udell JA, Cavender MA, Bhatt DL, Chatterjee S, Farkouh ME & Scirica BM. Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials. Lancet Diabetes and Endocrinology 2015 3 356-366.
    • (2015) Lancet Diabetes and Endocrinology , vol.3 , pp. 356-366
    • Udell, J.A.1    Cavender, M.A.2    Bhatt, D.L.3    Chatterjee, S.4    Farkouh, M.E.5    Scirica, B.M.6
  • 57
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN & Newsholme EA. The glucose fatty-acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1963 281 785-789. (https:// doi.org/10.1016/S0140-6736(63)91500-9)
    • (1963) Lancet , vol.281 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 58
    • 84964253450 scopus 로고    scopus 로고
    • Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy
    • Zhang L, Ding W-Y, Wang Z-H, Tang M-X, Wang F, Li Y, Zhong M, Zhang Y & Zhang W. Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. Journal of Translational Medicine 2016 14 109. (https://doi.org/10.1186/s12967-016-0849-1)
    • (2016) Journal of Translational Medicine , vol.14 , pp. 109
    • Zhang, L.1    Ding, W.-Y.2    Wang, Z.-H.3    Tang, M.-X.4    Wang, F.5    Li, Y.6    Zhong, M.7    Zhang, Y.8    Zhang, W.9
  • 60
    • 84875227824 scopus 로고    scopus 로고
    • The effect of trimetazidine on cardiac function in diabetic patients with idiopathic dilated cardiomyopathy
    • Zhao P, Zhang J, Yin X-G, Maharaj P, Narraindoo S, Cui L-Q & Tang YS. The effect of trimetazidine on cardiac function in diabetic patients with idiopathic dilated cardiomyopathy. Life Sciences 2013 92 633-638. (https://doi.org/10.1016/j.lfs.2012.03.015)
    • (2013) Life Sciences , vol.92 , pp. 633-638
    • Zhao, P.1    Zhang, J.2    Yin, X.-G.3    Maharaj, P.4    Narraindoo, S.5    Cui, L.-Q.6    Tang, Y.S.7
  • 66
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    • Scott R, O'Brien R, Fulcher G, Pardy C, d'Emden M, Tse D, Taskinen MR, Ehnholm C, Keech A & Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators. Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009 32 493-498.
    • (2009) Diabetes Care , vol.32 , pp. 493-498
    • Scott, R.1    O'Brien, R.2    Fulcher, G.3    Pardy, C.4    D'Emden, M.5    Tse, D.6    Taskinen, M.R.7    Ehnholm, C.8    Keech, A.9
  • 67
    • 79551494641 scopus 로고    scopus 로고
    • Metabolic modulation in heart failure: High time for a definitive clinical trial
    • Ashrafian H & Neubauer S. Metabolic modulation in heart failure: high time for a definitive clinical trial. Heart 2011 97 267-268. (https://doi.org/10.1136/hrt.2010.214932)
    • (2011) Heart , vol.97 , pp. 267-268
    • Ashrafian, H.1    Neubauer, S.2
  • 68
    • 46849089267 scopus 로고    scopus 로고
    • Metabolic reserve of the heart: The forgotten link between contraction and coronary flow
    • Kassiotis C, Rajabi M & Taegtmeyer H. Metabolic reserve of the heart: the forgotten link between contraction and coronary flow. Progress in Cardiovascular Diseases 2008 51 74-88. (https://doi.org/10.1016/j. pcad.2007.11.005)
    • (2008) Progress in Cardiovascular Diseases , vol.51 , pp. 74-88
    • Kassiotis, C.1    Rajabi, M.2    Taegtmeyer, H.3
  • 71
    • 84880975804 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes
    • Monji A, Mitsui T, Bando YK, Aoyama M, Shigeta T & Murohara T. Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes. American Journal of Physiology - Heart and Circulatory Physiology 2013 305 H295-H304. (https://doi.org/10.1152/ ajpheart.00990.2012)
    • (2013) American Journal of Physiology - Heart and Circulatory Physiology , vol.305 , pp. H295-H304
    • Monji, A.1    Mitsui, T.2    Bando, Y.K.3    Aoyama, M.4    Shigeta, T.5    Murohara, T.6
  • 73
    • 2442536114 scopus 로고    scopus 로고
    • Regional body composition changes exhibit opposing effects on coronary heart disease risk factors
    • Okura T, Nakata Y, Yamabuki K & Tanaka K. Regional body composition changes exhibit opposing effects on coronary heart disease risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 923-929. (https://doi.org/10.1161/01. ATV.0000125702.26272.f6)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , pp. 923-929
    • Okura, T.1    Nakata, Y.2    Yamabuki, K.3    Tanaka, K.4
  • 74
    • 34247325960 scopus 로고    scopus 로고
    • Adipose tissue and atherosclerosis: Exploring the connection
    • Fantuzzi G & Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 996-1003. (https://doi.org/10.1161/ ATVBAHA.106.131755)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , pp. 996-1003
    • Fantuzzi, G.1    Mazzone, T.2
  • 82
    • 84926417636 scopus 로고    scopus 로고
    • Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: Association with the severity of liver disease
    • Petta S, Argano C, Colomba D, Cammà C, Di Marco V, Cabibi D, Tuttolomondo A, Marchesini G, Pinto A, Licata G et al. Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: association with the severity of liver disease. Journal of Hepatology 2015 62 928-933. (https://doi.org/10.1016/j. jhep.2014.11.030)
    • (2015) Journal of Hepatology , vol.62 , pp. 928-933
    • Petta, S.1    Argano, C.2    Colomba, D.3    Cammà, C.4    Di Marco, V.5    Cabibi, D.6    Tuttolomondo, A.7    Marchesini, G.8    Pinto, A.9    Licata, G.10
  • 83
    • 12444296524 scopus 로고    scopus 로고
    • Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    • Heilbronn L, Smith SR & Ravussin E. Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. International Journal of Obesity and Related Metabolic Disorders 2004 28 S12-S21.
    • (2004) International Journal of Obesity and Related Metabolic Disorders , vol.28 , pp. S12-S21
    • Heilbronn, L.1    Smith, S.R.2    Ravussin, E.3
  • 84
    • 84884418143 scopus 로고    scopus 로고
    • Cardiac steatosis and left ventricular hypertrophy in patients with generalized lipodystrophy as determined by magnetic resonance spectroscopy and imaging
    • Nelson MD, Victor RG, Szczepaniak EW, Simha V, Garg A & Szczepaniak LS. Cardiac steatosis and left ventricular hypertrophy in patients with generalized lipodystrophy as determined by magnetic resonance spectroscopy and imaging. American Journal of Cardiology 2013 112 1019-1024. (https://doi.org/10.1016/j. amjcard.2013.05.036)
    • (2013) American Journal of Cardiology , vol.112 , pp. 1019-1024
    • Nelson, M.D.1    Victor, R.G.2    Szczepaniak, E.W.3    Simha, V.4    Garg, A.5    Szczepaniak, L.S.6
  • 85
    • 84908192495 scopus 로고    scopus 로고
    • Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: Testing the "adipose tissue expandability" hypothesis
    • Johannsen DL, Tchoukalova Y, Tam CS, Covington JD, Xie W, Schwarz J-M, Bajpeyi S & Ravussin E. Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the "adipose tissue expandability" hypothesis. Diabetes Care 2014 37 2789-2797. (https://doi.org/10.2337/dc14-0761)
    • (2014) Diabetes Care , vol.37 , pp. 2789-2797
    • Johannsen, D.L.1    Tchoukalova, Y.2    Tam, C.S.3    Covington, J.D.4    Xie, W.5    Schwarz, J.-M.6    Bajpeyi, S.7    Ravussin, E.8
  • 86
    • 0036402110 scopus 로고    scopus 로고
    • Metabolic lessons from genetically lean mice
    • Reitman ML. Metabolic lessons from genetically lean mice. Annual Review of Nutrition 2002 22 459-482. (https://doi.org/10.1146/ annurev.nutr.22.010402.102849)
    • (2002) Annual Review of Nutrition , vol.22 , pp. 459-482
    • Reitman, M.L.1
  • 87
    • 37849047917 scopus 로고    scopus 로고
    • Insulin-resistant cardiomyopathy: Clinical evidence, mechanisms, and treatment options
    • Witteles RM & Fowler MB. Insulin-resistant cardiomyopathy: clinical evidence, mechanisms, and treatment options. Journal of the American College of Cardiology 2008 51 93-102. (https://doi. org/10.1016/j.jacc.2007.10.021)
    • (2008) Journal of the American College of Cardiology , vol.51 , pp. 93-102
    • Witteles, R.M.1    Fowler, M.B.2
  • 88
    • 84863205222 scopus 로고    scopus 로고
    • Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex
    • Zhang Q-J, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D et al. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes 2012 61 1848-1859. (https://doi.org/10.2337/db11-1399)
    • (2012) Diabetes , vol.61 , pp. 1848-1859
    • Zhang, Q.-J.1    Holland, W.L.2    Wilson, L.3    Tanner, J.M.4    Kearns, D.5    Cahoon, J.M.6    Pettey, D.7    Losee, J.8    Duncan, B.9    Gale, D.10
  • 89
    • 33645280925 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: The search for a unifying hypothesis
    • Poornima IG, Parikh P & Shannon RP. Diabetic cardiomyopathy: the search for a unifying hypothesis. Circulation Research 2006 98 596-605. (https://doi.org/10.1161/01.RES.0000207406.94146.c2)
    • (2006) Circulation Research , vol.98 , pp. 596-605
    • Poornima, I.G.1    Parikh, P.2    Shannon, R.P.3
  • 92
    • 84962109426 scopus 로고    scopus 로고
    • Insulin resistance as a physiological defense against metabolic stress: Implications for the management of subsets of type 2 diabetes
    • Nolan CJ, Ruderman NB, Kahn SE, Pedersen O & Prentki M. Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes 2015 64 673-686. (https://doi.org/10.2337/db14-0694)
    • (2015) Diabetes , vol.64 , pp. 673-686
    • Nolan, C.J.1    Ruderman, N.B.2    Kahn, S.E.3    Pedersen, O.4    Prentki, M.5
  • 93
    • 84864768735 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians
    • Thakur ML, Sharma S, Kumar A, Bhatt SP, Luthra K, Guleria R, Pandey RM & Vikram NK. Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians. Atherosclerosis 2012 223 507-511. (https://doi.org/10.1016/j. atherosclerosis.2012.06.005)
    • (2012) Atherosclerosis , vol.223 , pp. 507-511
    • Thakur, M.L.1    Sharma, S.2    Kumar, A.3    Bhatt, S.P.4    Luthra, K.5    Guleria, R.6    Pandey, R.M.7    Vikram, N.K.8
  • 98
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE & Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. New England Journal of Medicine 2007 356 2457-2471. (https://doi. org/10.1056/NEJMoa072761)
    • (2007) New England Journal of Medicine , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 100
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ & Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006 368 1696-1705. (https://doi. org/10.1016/S0140-6736(06)69705-5)
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 101
    • 84962109496 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism
    • Lutz TA & Osto E. Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism. Current Opinion in Lipidology 2016 27 257-263. (https://doi.org/10.1097/MOL.0000000000000293)
    • (2016) Current Opinion in Lipidology , vol.27 , pp. 257-263
    • Lutz, T.A.1    Osto, E.2
  • 102
    • 33745771673 scopus 로고    scopus 로고
    • Biologic actions and therapeutic potential of the proglucagon-derived peptides
    • Drucker DJ. Biologic actions and therapeutic potential of the proglucagon-derived peptides. Nature Clinical Practice Endocrinology and Metabolism 2005 1 22-31. (https://doi.org/10.1038/ ncpendmet0017)
    • (2005) Nature Clinical Practice Endocrinology and Metabolism , vol.1 , pp. 22-31
    • Drucker, D.J.1
  • 103
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hüfner M & Schmiegel WH. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. Journal of Clinical Endocrinology and Metabolism 2002 87 1239-1246.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3    Holst, J.J.4    Nauck, M.S.5    Ritzel, R.6    Hüfner, M.7    Schmiegel, W.H.8
  • 104
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, Stolarski C, Shen YT & Shannon RP. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004 110 955.
    • (2004) Circulation , vol.110 , pp. 955
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.T.8    Shannon, R.P.9
  • 105
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/ reperfusion injury
    • Bose AK, Mocanu MM, Carr RD, Brand CL & Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/ reperfusion injury. Diabetes 2004 54 146.
    • (2004) Diabetes , vol.54 , pp. 146
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 108
    • 84982082404 scopus 로고    scopus 로고
    • Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: A randomized clinical trial
    • Margulies KB, Hernandez AF, Redfield MM, Givertz MM, Oliveira GH, Cole R, Mann DL, Whellan DJ, Kiernan MS, Felker GM et al. Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial. JAMA 2016 316 500-508. (https://doi.org/10.1001/jama.2016.10260)
    • (2016) JAMA , vol.316 , pp. 500-508
    • Margulies, K.B.1    Hernandez, A.F.2    Redfield, M.M.3    Givertz, M.M.4    Oliveira, G.H.5    Cole, R.6    Mann, D.L.7    Whellan, D.J.8    Kiernan, M.S.9    Felker, G.M.10
  • 113
    • 84946409554 scopus 로고    scopus 로고
    • Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance
    • Abdesselam I, Pepino P, Troalen T, Macia M, Ancel P, Masi B, Fourny N, Gaborit B, Giannesini B, Kober F et al. Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance 2015 17 95. (https://doi.org/10.1186/s12968-015-0198-x)
    • (2015) Journal of Cardiovascular Magnetic Resonance , vol.17 , pp. 95
    • Abdesselam, I.1    Pepino, P.2    Troalen, T.3    Macia, M.4    Ancel, P.5    Masi, B.6    Fourny, N.7    Gaborit, B.8    Giannesini, B.9    Kober, F.10
  • 115
    • 84923527667 scopus 로고    scopus 로고
    • Probing SGLT2 as a therapeutic target for diabetes: Basic physiology and consequences
    • Gallo LA, Wright EM & Vallon V. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diabetes and Vascular Disease Research 2015 12 78-89. (https://doi. org/10.1177/1479164114561992)
    • (2015) Diabetes and Vascular Disease Research , vol.12 , pp. 78-89
    • Gallo, L.A.1    Wright, E.M.2    Vallon, V.3
  • 119
    • 84987624200 scopus 로고    scopus 로고
    • The Na+/Glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels
    • Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR & Hardie DG. The Na+/Glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes 2016 65 2784-2794. (https://doi.org/10.2337/ db16-0058)
    • (2016) Diabetes , vol.65 , pp. 2784-2794
    • Hawley, S.A.1    Ford, R.J.2    Smith, B.K.3    Gowans, G.J.4    Mancini, S.J.5    Pitt, R.D.6    Day, E.A.7    Salt, I.P.8    Steinberg, G.R.9    Hardie, D.G.10
  • 120
    • 84919621076 scopus 로고    scopus 로고
    • AMPK - Sensing energy while talking to other signaling pathways
    • Hardie DG. AMPK - sensing energy while talking to other signaling pathways. Cell Metabolism 2014 20 939-952. (https://doi. org/10.1016/j.cmet.2014.09.013)
    • (2014) Cell Metabolism , vol.20 , pp. 939-952
    • Hardie, D.G.1
  • 121
    • 84964608804 scopus 로고    scopus 로고
    • Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
    • Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R, Mari A, Pieber TR & Muscelli E. Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes 2016 65 1190-1195. (https://doi.org/10.2337/db15-1356)
    • (2016) Diabetes , vol.65 , pp. 1190-1195
    • Ferrannini, E.1    Baldi, S.2    Frascerra, S.3    Astiarraga, B.4    Heise, T.5    Bizzotto, R.6    Mari, A.7    Pieber, T.R.8    Muscelli, E.9
  • 122
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME Study? A unifying hypothesis
    • Mudaliar S, Alloju S & Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME Study? A unifying hypothesis. Diabetes Care 2016 39 1115-1122. (https://doi.org/10.2337/dc16-0542)
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 123
    • 84876569165 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Pathophysiology and clinical features
    • Miki T, Yuda S, Kouzu H & Miura T. Diabetic cardiomyopathy: pathophysiology and clinical features. Heart Failure Reviews 2013 18 149-166. (https://doi.org/10.1007/s10741-012-9313-3)
    • (2013) Heart Failure Reviews , vol.18 , pp. 149-166
    • Miki, T.1    Yuda, S.2    Kouzu, H.3    Miura, T.4
  • 124
    • 20444410115 scopus 로고    scopus 로고
    • Nephropathy, but not retinopathy, is associated with the development of heart disease in Type 1 diabetes: A 12-year observation study of 462 patients
    • Torffvit O, Lövestam-Adrian M, Agardh E & Agardh CD. Nephropathy, but not retinopathy, is associated with the development of heart disease in Type 1 diabetes: a 12-year observation study of 462 patients. Diabetic Medicine 2005 22 723-729. (https://doi.org/10.1111/j.1464-5491.2005.01476.x)
    • (2005) Diabetic Medicine , vol.22 , pp. 723-729
    • Torffvit, O.1    Lövestam-Adrian, M.2    Agardh, E.3    Agardh, C.D.4
  • 126
    • 77955342200 scopus 로고    scopus 로고
    • Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes
    • Li J, Zhu H, Shen E, Wan L, Arnold JM & Peng T. Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes 2010 59 2033-2042.
    • (2010) Diabetes , vol.59 , pp. 2033-2042
    • Li, J.1    Zhu, H.2    Shen, E.3    Wan, L.4    Arnold, J.M.5    Peng, T.6
  • 128
    • 69549120052 scopus 로고    scopus 로고
    • Increased left ventricular torsion in uncomplicated type 1 diabetic patients: The role of coronary microvascular function
    • Shivu GN, Abozguia K, Phan TT, Ahmed I, Weaver R, Narendran P, Stevens M & Frenneaux M. Increased left ventricular torsion in uncomplicated type 1 diabetic patients: the role of coronary microvascular function. Diabetes Care 2009 32 1710-1712. (https:// doi.org/10.2337/dc09-0408)
    • (2009) Diabetes Care , vol.32 , pp. 1710-1712
    • Shivu, G.N.1    Abozguia, K.2    Phan, T.T.3    Ahmed, I.4    Weaver, R.5    Narendran, P.6    Stevens, M.7    Frenneaux, M.8
  • 129
    • 77950473439 scopus 로고    scopus 로고
    • Relationship between coronary microvascular dysfunction and cardiac energetics impairment in type 1 diabetes mellitus
    • Shivu GN, Phan TT, Abozguia K, Ahmed I, Wagenmakers A, Henning A, Narendran P, Stevens M & Frenneaux M. Relationship between coronary microvascular dysfunction and cardiac energetics impairment in type 1 diabetes mellitus. Circulation 2010 121 1209-1215. (https://doi.org/10.1161/ CIRCULATIONAHA.109.873273)
    • (2010) Circulation , vol.121 , pp. 1209-1215
    • Shivu, G.N.1    Phan, T.T.2    Abozguia, K.3    Ahmed, I.4    Wagenmakers, A.5    Henning, A.6    Narendran, P.7    Stevens, M.8    Frenneaux, M.9


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