메뉴 건너뛰기




Volumn 3, Issue 3, 2015, Pages 202-211

Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy

Author keywords

Heart failure; Magnetic resonance spectroscopy; Myocardial metabolism; Perhexiline

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATINE PHOSPHATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FATTY ACID; MINERALOCORTICOID ANTAGONIST; PERHEXILINE; PLACEBO; CARDIOVASCULAR AGENT;

EID: 84924984745     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2014.09.009     Document Type: Article
Times cited : (80)

References (26)
  • 1
    • 0034820506 scopus 로고    scopus 로고
    • More 'malignant' than cancer? Five-year survival following a first admission forheart failure
    • Stewart S., MacIntyre K., Hole D.J., Capewell S., McMurray J.J. More 'malignant' than cancer? Five-year survival following a first admission forheart failure. Eur J Heart Fail 2001, 3:315-322.
    • (2001) Eur J Heart Fail , vol.3 , pp. 315-322
    • Stewart, S.1    MacIntyre, K.2    Hole, D.J.3    Capewell, S.4    McMurray, J.J.5
  • 2
    • 0028866659 scopus 로고
    • Amultidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure
    • Rich M.W., Beckham V., Wittenberg C., Leven C.L., Freedland K.E., Carney R.M. Amultidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. NEngl J Med 1995, 333:1190-1195.
    • (1995) NEngl J Med , vol.333 , pp. 1190-1195
    • Rich, M.W.1    Beckham, V.2    Wittenberg, C.3    Leven, C.L.4    Freedland, K.E.5    Carney, R.M.6
  • 3
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S. The failing heart-an engine out of fuel. NEngl J Med 2007, 356:1140-1151.
    • (2007) NEngl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 4
    • 0025343177 scopus 로고
    • Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent
    • Cole P.L., Beamer A.D., McGowan N., et al. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation 1990, 81:1260-1270.
    • (1990) Circulation , vol.81 , pp. 1260-1270
    • Cole, P.L.1    Beamer, A.D.2    McGowan, N.3
  • 5
    • 33644875657 scopus 로고    scopus 로고
    • Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment
    • Lee L., Campbell R., Scheuermann-Freestone M., et al. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation 2005, 112:3280-3288.
    • (2005) Circulation , vol.112 , pp. 3280-3288
    • Lee, L.1    Campbell, R.2    Scheuermann-Freestone, M.3
  • 6
    • 78049509377 scopus 로고    scopus 로고
    • Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy
    • Abozguia K., Elliott P., McKenna W., et al. Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation 2010, 122:1562-1569.
    • (2010) Circulation , vol.122 , pp. 1562-1569
    • Abozguia, K.1    Elliott, P.2    McKenna, W.3
  • 7
    • 0022451358 scopus 로고
    • Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics
    • Horowitz J.D., Sia S.T., Macdonald P.S., Goble A.J., Louis W.J. Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics. Int J Cardiol 1986, 13:219-229.
    • (1986) Int J Cardiol , vol.13 , pp. 219-229
    • Horowitz, J.D.1    Sia, S.T.2    Macdonald, P.S.3    Goble, A.J.4    Louis, W.J.5
  • 8
    • 0030602865 scopus 로고    scopus 로고
    • Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone
    • Kennedy J.A., Unger S.A., Horowitz J.D. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem Pharmacol 1996, 52:273-280.
    • (1996) Biochem Pharmacol , vol.52 , pp. 273-280
    • Kennedy, J.A.1    Unger, S.A.2    Horowitz, J.D.3
  • 9
    • 0032492358 scopus 로고    scopus 로고
    • Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium
    • Bottomley P.A., Weiss R.G. Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium. Lancet 1998, 351:714-718.
    • (1998) Lancet , vol.351 , pp. 714-718
    • Bottomley, P.A.1    Weiss, R.G.2
  • 10
    • 0026000171 scopus 로고
    • Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy
    • Conway M.A., Allis J., Ouwerkerk R., Niioka T., Rajagopalan B., Radda G.K. Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy. Lancet 1991, 338:973-976.
    • (1991) Lancet , vol.338 , pp. 973-976
    • Conway, M.A.1    Allis, J.2    Ouwerkerk, R.3    Niioka, T.4    Rajagopalan, B.5    Radda, G.K.6
  • 11
    • 84883590704 scopus 로고    scopus 로고
    • Molecular changes after left ventricular assist device support for heart failure
    • Birks E.J. Molecular changes after left ventricular assist device support for heart failure. Circ Res 2013, 113:777-791.
    • (2013) Circ Res , vol.113 , pp. 777-791
    • Birks, E.J.1
  • 12
    • 0343484919 scopus 로고    scopus 로고
    • EffectsofACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction
    • Hugel S., Horn M., de Groot M., et al. EffectsofACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction. Am J Physiol 1999, 277:H2167-H2175.
    • (1999) Am J Physiol , vol.277 , pp. H2167-H2175
    • Hugel, S.1    Horn, M.2    de Groot, M.3
  • 13
    • 0028879801 scopus 로고
    • Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction
    • Sanbe A., Tanonaka K., Kobayasi R., Takeo S. Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction. JMol Cell Cardiol 1995, 27:2209-2222.
    • (1995) JMol Cell Cardiol , vol.27 , pp. 2209-2222
    • Sanbe, A.1    Tanonaka, K.2    Kobayasi, R.3    Takeo, S.4
  • 14
    • 79957925338 scopus 로고    scopus 로고
    • Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial
    • Beadle R.M., Williams L.K., Abozguia K., et al. Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial. Trials 2011, 12:140.
    • (2011) Trials , vol.12 , pp. 140
    • Beadle, R.M.1    Williams, L.K.2    Abozguia, K.3
  • 15
    • 0032902352 scopus 로고    scopus 로고
    • An immunoluminometric assay for N-terminalpro-brain natriuretic peptide: development of a test for left ventricular dysfunction
    • Hughes D., Talwar S., Squire I.B., Davies J.E., Ng L.L. An immunoluminometric assay for N-terminalpro-brain natriuretic peptide: development of a test for left ventricular dysfunction. Clin Sci (Lond) 1999, 96:373-380.
    • (1999) Clin Sci (Lond) , vol.96 , pp. 373-380
    • Hughes, D.1    Talwar, S.2    Squire, I.B.3    Davies, J.E.4    Ng, L.L.5
  • 16
    • 0032485850 scopus 로고    scopus 로고
    • Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans
    • Conway M.A., Bottomley P.A., Ouwerkerk R., Radda G.K., Rajagopalan B. Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans. Circulation 1998, 97:1716-1723.
    • (1998) Circulation , vol.97 , pp. 1716-1723
    • Conway, M.A.1    Bottomley, P.A.2    Ouwerkerk, R.3    Radda, G.K.4    Rajagopalan, B.5
  • 18
    • 0038613602 scopus 로고    scopus 로고
    • The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population
    • Thackray S.D., Witte K.K., Nikitin N.P., Clark A.L., Kaye G.C., Cleland J.G. The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population. Eur Heart J 2003, 24:1143-1152.
    • (2003) Eur Heart J , vol.24 , pp. 1143-1152
    • Thackray, S.D.1    Witte, K.K.2    Nikitin, N.P.3    Clark, A.L.4    Kaye, G.C.5    Cleland, J.G.6
  • 19
    • 0024723470 scopus 로고
    • Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation ofTwo-Dimensional Echocardiograms
    • Schiller N.B., Shah P.M., Crawford M., et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation ofTwo-Dimensional Echocardiograms. JAm Soc Echocardiogr 1989, 2:358-367.
    • (1989) JAm Soc Echocardiogr , vol.2 , pp. 358-367
    • Schiller, N.B.1    Shah, P.M.2    Crawford, M.3
  • 20
    • 76349093379 scopus 로고    scopus 로고
    • (31)P magnetic resonancespectroscopy to measure invivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: experiences at 3T
    • Shivu G.N., Abozguia K., Phan T.T., Ahmed I., Henning A., Frenneaux M. (31)P magnetic resonancespectroscopy to measure invivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: experiences at 3T. Eur J Radiol 2010, 73:255-259.
    • (2010) Eur J Radiol , vol.73 , pp. 255-259
    • Shivu, G.N.1    Abozguia, K.2    Phan, T.T.3    Ahmed, I.4    Henning, A.5    Frenneaux, M.6
  • 22
    • 84874168194 scopus 로고    scopus 로고
    • NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation
    • Gatto G.J., Ao Z., Kearse M.G., et al. NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation. JEnzyme Inhib Med Chem 2013, 28:95-104.
    • (2013) JEnzyme Inhib Med Chem , vol.28 , pp. 95-104
    • Gatto, G.J.1    Ao, Z.2    Kearse, M.G.3
  • 23
    • 70349616273 scopus 로고    scopus 로고
    • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
    • Balgi A.D., Fonseca B.D., Donohue E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 2009, 4:e7124.
    • (2009) PLoS One , vol.4 , pp. e7124
    • Balgi, A.D.1    Fonseca, B.D.2    Donohue, E.3
  • 24
    • 84874935310 scopus 로고    scopus 로고
    • Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure
    • Dedkova E.N., Seidlmayer L.K., Blatter L.A. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. JMol Cell Cardiol 2013, 59:41-54.
    • (2013) JMol Cell Cardiol , vol.59 , pp. 41-54
    • Dedkova, E.N.1    Seidlmayer, L.K.2    Blatter, L.A.3
  • 25
    • 79551469280 scopus 로고    scopus 로고
    • Trimetazidine: a meta-analysis of randomised controlled trials in heart failure
    • Gao D., Ning N., Niu X., Hao G., Meng Z. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart 2011, 97:278-286.
    • (2011) Heart , vol.97 , pp. 278-286
    • Gao, D.1    Ning, N.2    Niu, X.3    Hao, G.4    Meng, Z.5
  • 26
    • 33645466318 scopus 로고    scopus 로고
    • Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
    • Fragasso G., Perseghin G., De Cobelli F., et al. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure. Eur Heart J 2006, 27:942-948.
    • (2006) Eur Heart J , vol.27 , pp. 942-948
    • Fragasso, G.1    Perseghin, G.2    De Cobelli, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.