Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: Amultiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms

European Heart Journal Cardiovascular Imaging

Volumn 15, Issue 11, 2014, Pages 1263-1269

  Khan, Jamal Nasir ^a,b   Wilmot, Emma Gwyn ^a,b,c   Leggate, Melanie ^c,d   Singh, Anvesha ^a,b   Yates, Thomas ^a,c   Nimmo, Myra ^c,d   Khunti, Kamlesh ^a,c   Horsfield, Mark A ^a,b   Biglands, John ^e   Clarysse, Patrick ^f   Croisille, Pierre ^f   Davies, Melanie ^a,b,c   McCann, Gerry Patrick ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLENFIELD HOSPITAL   (United Kingdom)

^c LEICESTER GENERAL HOSPITAL   (United Kingdom)

^d LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^e LEEDS GENERAL INFIRMARY   (United Kingdom)

^f UNIVERSITÉ DE LYON   (France)

Author keywords

Aortic distensibility; Cardiac magnetic resonance imaging; Diabetes mellitus; Diabetic cardiomyopathies; Diabetic diastolic heart failure; Diastolic dysfunction diabetes mellitus

Indexed keywords

GADOLINIUM; BIOLOGICAL MARKER; CONTRAST MEDIUM;

ADULT; ARTERIAL STIFFNESS; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DISEASE DURATION; FEMALE; HEART DILATATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE FIBROSIS; HEART MUSCLE PERFUSION; HEART VOLUME; HUMAN; MALE; MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE SCANNER; PARTITION COEFFICIENT; PILOT STUDY; PRIORITY JOURNAL; PULSE WAVE; STEATOSIS; SYSTOLE; YOUNG ADULT; ANTHROPOMETRY; BLOOD; CARDIAC GATED IMAGING; CASE CONTROL STUDY; COMPLICATION; DIASTOLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART FAILURE, DIASTOLIC; HEART FUNCTION TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PROCEDURES; RISK FACTOR;

ADULT; ANTHROPOMETRY; BIOMARKERS; CARDIAC-GATED IMAGING TECHNIQUES; CASE-CONTROL STUDIES; CONTRAST MEDIA; DIABETES MELLITUS, TYPE 2; DIASTOLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART FAILURE, DIASTOLIC; HEART FUNCTION TESTS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PILOT PROJECTS; RISK FACTORS;

EID: 84986916245     PISSN: 20472404     EISSN: 20472412     Source Type: Journal    
DOI: 10.1093/ehjci/jeu121     Document Type: Article

References (38)

1. Schmidt A, Friedrich M. Imaging targets in diabetic cardiomyopathy : current status and perspective. Can J Diabetes 2011;35:353-62.
2. von Bibra H, St John Sutton M. Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosis. Diabetologia 2010;53: 1033-45.
3. Tillquist MN, Maddox TM. Update on diabetic cardiomyopathy: inches forward, miles to go. Curr Diab Rep 2012;12:305-13.
4. Kiencke S, Handschin R, von Dahlen R, Muser J, Brunner-Larocca HP, Schumann J et al. Pre-clinical diabetic cardiomyopathy: prevalence, screening, and outcome. Eur J Heart Fail 2010;12:951-7.
5. Hsia Y, Neubert AC, Rani F, Viner RM, Hindmarsh PC, Wong IC. An increase in the prevalence of type 1 and 2 diabetes in children and adolescents: results fromprescription data from a UK general practice database. Br J Clin Pharmacol 2009;67:242-9.
6. Wilmot EG, Davies MJ, YatesT, Benhalima K, Lawrence IG, Khunti K. Type 2 diabetes in younger adults: the emerging UK epidemic. Postgrad Med J 2010;86:711-8.
7. Constantino MI, Molyneaux L, Limacher-Gisler F, Al-Saeed A, Luo C, Wu T et al. Long-term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care 2013;36:3863-9.
8. Hillier TA, Pedula KL. Complications in young adults with early-onset type 2 diabetes: losing the relative protection of youth. Diabetes Care 2003;26:2999-3005.
9. Wilmot EG, Leggate M, Khan JN, Yates T, Gorely T, Bodicoat DH et al. Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabet Med 2014. doi: 10.1111/dme.12431.
10. Steadman CD, Jerosch-Herold M, Grundy B, Rafelt S, Ng LL, Squire IB et al. Determinants and functional significance of myocardial perfusion reserve in severe aortic stenosis. JACC Cardiovasc Imaging 2012;5:182-9.
11. Zwanenburg JJ, Gotte MJ, Kuijer JP, Hofman MB, Knaapen P, Heethaar RM et al. Regional timing of myocardial shortening is related to prestretch from atrial contraction: assessment by high temporal resolution MRI tagging in humans. Am J Physiol Heart Circ Physiol 2005;288:H787-94.
12. Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 2004;52:141-6.
13. Miller CA, Borg A, Clark D, Steadman CD, McCann GP, Clarysse P et al. Comparison of local sine wave modeling with harmonic phase analysis for the assessment of myocardial strain. J Magn Reson Imaging 2013;38:320-8.
14. Jerosch-Herold M, Swingen C, Seethamraju RT. Myocardial blood flow quantification with MRI by model-independent deconvolution. Med Phys 2002;29:886-97.
15. Biglands J, Magee D, Boyle R, Larghat A, Plein S, Radjenovic A. Evaluation of the effect of myocardial segmentation errors on myocardial blood flow estimates from DCE-MRI. Phys Med Biol 2011;56:2423-43.
16. Flacke SJ, Fischer SE, Lorenz CH. Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction. Radiology 2001;218:703-10.
17. Rider OJ, Tayal U, Francis JM, Ali MK, Robinson MR, Byrne JP et al. The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging. Obesity 2010;18:2311-6.
18. Little WC, Applegate RJ. Congestive heart failure: systolic and diastolic function. J Cardiothorac Vasc Anesth 1993;7(4 Suppl 2):2-5.
19. Maisch B, Alter P, Pankuweit S. Diabetic cardiomyopathy-fact or fiction? Herz 2011; 36:102-15.
20. Fernandes VR, Polak JF, Cheng S, Rosen BD, Carvalho B, Nasir K et al. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 2008;28:194-201.
21. van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ et al. Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. Int J Cardiovasc Imaging 2013;29:633-41.
22. Seyfeli E, Duru M, Saglam H, Akgul F, Kuvandik G, Kaya H et al. Association of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue Doppler echocardiographic study. Int J Clin Pract 2008;62:1358-65.
23. Kim Y, Shin MS, Kim YS, Kang WC, Kim BR, Moon J et al. The impact of diabetes duration on left ventricular diastolic function and cardiovascular disease. Postgrad Med J 2012;88:189-93.
24. Patil VC, Patil HV, Shah KB, Vasani JD, Shetty P. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc Dis Res 2011;2: 213-22.
25. Hammer S, Snel M, Lamb HJ, Jazet IM, van der Meer RW, Pijl H et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol 2008;52:1006-12.
26. Wang L, Jerosch-Herold M, Jacobs DR Jr., Shahar E, Detrano R, Folsom AR. Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2006;48:1018-26.
27. Shivu GN, Phan TT, Abozguia K, Ahmed I, Wagenmakers A, Henning A et al. Relationship between coronary microvascular dysfunction and cardiac energetics impairment in type 1 diabetes mellitus. Circulation 2010;121:1209-15.
28. Korosoglou G, Humpert PM, Ahrens J, Oikonomou D, Osman NF, GitsioudisGet al. Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve. J Magn Reson Imaging 2012;35:804-11.
29. Fiorina P, La Rocca E, Venturini M, Minicucci F, Fermo I, Paroni R et al. Effects of kidney-pancreas transplantationonatherosclerotic risk factors and endothelial function in patients with uremia and type 1 diabetes. Diabetes 2001;50:496-501.
30. von Bibra H, Siegmund T, Hansen A, Jensen J, Schumm-Draeger PM. Augmentation of myocardial function by improved glycemic control in patients with type 2 diabetes mellitus. Dtsch Med Wochenschr 2007;132:729-34.
31. Fang ZY, Schull-Meade R, Downey M, Prins J, Marwick TH. Determinants of subclinical diabetic heart disease. Diabetologia 2005;48:394-402.
32. Jarnert C, Landstedt-Hallin L, Malmberg K, Melcher A, Ohrvik J, Persson H et al. A randomized trial of the impact of strict glycaemic control on myocardial diastolic function and perfusion reserve: a report from the DADD (Diabetes mellitus And Diastolic Dysfunction) study. Eur J Heart Fail 2009;11:39-47.
33. Ng AC, Delgado V, Bertini M, van der Meer RW, Rijzewijk LJ, Hooi Ewe S et al. Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus. Circulation 2010;122:2538-44.
34. McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 2007; 116:1170-5.
35. Rijzewijk LJ, van der Meer RW, Smit JW, Diamant M, Bax JJ, Hammer S et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J Am Coll Cardiol 2008;52:1793-9.
36. Brindley DN, Kok BP, Kienesberger PC, Lehner R, Dyck JR. Shedding light on the enigma ofmyocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization. Am J Physiol Endocrinol Metab 2010;298:E897-908.
37. Liu CY, Redheuil A, Steenbergen C, Lima JA, Bluemke A. Measurement of myocardial triglyceride content by magnetic resonance spectroscopy in transplant native heart autopsies. JCMR 2010;12(Suppl 1):125.
38. Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011;54:2506-14.