Periaortic fat deposition is associated with peripheral arterial disease: The framingham heart study

Circulation: Cardiovascular Imaging

Volumn 3, Issue 5, 2010, Pages 515-519

  Fox, Caroline S ^a,e   Massaro, Joseph M ^a   Schlett, Christopher L ^b   Lehman, Sam J ^b,c   Meigs, James B ^a   O'Donnell, Christopher J ^a   Hoffmann, Udo ^b   Murabito, Joanne M ^a,b,d,f  

^a FRAMINGHAM HEART STUDY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FLINDERS UNIVERSITY   (Australia)

^d Boston University   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Obesity; Peripheral vascular diseases

Indexed keywords

AGED; ANKLE BRACHIAL INDEX; AORTA; ARTERY DISEASE; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; HUMAN; INTERMITTENT CLAUDICATION; INTRAABDOMINAL FAT; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; REGRESSION ANALYSIS; REVASCULARIZATION; THORACIC AORTA; WAIST CIRCUMFERENCE; ABDOMINAL FAT; ABDOMINAL OBESITY; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL STUDY; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; PERIPHERAL VASCULAR DISEASE; RADIOGRAPHY; RISK; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

ABDOMINAL FAT; ADIPOSITY; AGED; ANKLE BRACHIAL INDEX; AORTA, THORACIC; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTERMITTENT CLAUDICATION; LOGISTIC MODELS; MALE; MIDDLE AGED; OBESITY, ABDOMINAL; ODDS RATIO; PERIPHERAL VASCULAR DISEASES; RISK ASSESSMENT; RISK FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77957354898     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.110.958884     Document Type: Article

References (25)

1. Ostchega Y, Paulose-Ram R, Dillon CF, Gu Q, Hughes JP. Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: Data from the National Health and Nutrition Examination Survey 1999-2004. J Am Geriatr Soc. 2007;55:583-589. (Pubitemid 46496588)
2. Murabito JM, D'Agostino RB, Silbershatz H, Wilson WF. Intermittent claudication. A risk profile from The Framingham Heart Study. Circulation. 1997;96:44-49. (Pubitemid 27298402)
3. Saw J, Bhatt DL, Moliterno DJ, Brener SJ, Steinhubl SR, Lincoff AM, Tcheng JE, Harrington RA, Simoons M, Hu T, Sheikh MA, Kereiakes DJ, Topol EJ. The influence of peripheral arterial disease on outcomes: A pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials. J Am Coll Cardiol. 2006;48:1567-1572. (Pubitemid 44528177)
4. Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, D'Agostino RB, Murabito JM, Norman PE, Jamrozik K, Curb JD, Masaki KH, Rodriguez BL, Dekker JM, Bouter LM, Heine RJ, Nijpels G, Stehouwer CD, Ferrucci L, McDermott MM, Stoffers HE, Hooi JD, Knottnerus JA, Ogren M, Hedblad B, Witteman JC, Breteler MM, Hunink MG, Hofman A, Criqui MH, Langer RD, Fronek A, Hiatt WR, Hamman R, Resnick HE, Guralnik J, McDermott MM. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: A meta-analysis. JAMA. 2008;300: 197-208. (Pubitemid 351969304)
5. Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: Results from the National Health and Nutrition Examination Survey, 1999 -2000. Circulation. 2004;110: 738-743. (Pubitemid 39056275)
6. Planas A, Clara A, Pou JM, Vidal-Barraquer F, Gasol A, de MA, Contreras C, Marrugat J. Relationship of obesity distribution and peripheral arterial occlusive disease in elderly men. Int J Obes Relat Metab Disord. 2001;25:1068-1070. (Pubitemid 32566064)
7. Vogt MT, Cauley JA, Kuller LH, Hulley SB. Prevalence and correlates of lower extremity arterial disease in elderly women. Am J Epidemiol. 1993;137:559-568. (Pubitemid 23109757)
8. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D'Agostino RB Sr, O'Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116:39-48. (Pubitemid 47016245)
9. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. Circulation. 2008;117:605-613.
10. Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord. 2004;28(suppl 4):S58-S65. (Pubitemid 40143850)
11. Yudkin JS, Eringa E, Stehouwer CD. "Vasocrine" signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease. Lancet. 2005;365:1817-1820. (Pubitemid 40744663)
12. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, Heagerty AM. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009; 119:1661-1670.
13. Chatterjee TK, Stoll LL, Denning GM, Harrelson A, Blomkalns AL, Idelman G, Rothenberg FG, Neltner B, Romig-Martin SA, Dickson EW, Rudich S, Weintraub NL. Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding. Circ Res. 2009;104:541-549.
14. Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: Effects of aging and obesity. Am J Physiol Heart Circ Physiol. 2005;289: H1807-H1813. (Pubitemid 41507326)
15. Schlett CL, Massaro JM, Lehman SJ, Bamberg F, O'Donnell CJ, Fox CS, Hoffmann U. Novel measurements of periaortic adipose tissue in comparison to anthropometric measures of obesity, and abdominal adipose tissue. Int J Obes (Lond). 2009;33:226-232.
16. Deleted in proof.
17. Maurovich-Horvat P, Massaro J, Fox CS, Moselewski F, O'Donnell CJ, Hoffmann U. Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond). 2007;31:500-506.
18. McDermott MM, Liu K, Criqui MH, Ruth K, Goff D, Saad MF, Wu C, Homma S, Sharrett AR. Ankle-brachial index and subclinical cardiac and carotid disease: The multi-ethnic study of atherosclerosis. Am J Epidemiol. 2005;162:33-41. (Pubitemid 40884998)
19. Meijer WT, Hoes AW, Rutgers D, Bots ML, Hofman A, Grobbee DE. Peripheral arterial disease in the elderly: The Rotterdam Study. Arterioscler Thromb Vasc Biol. 1998;18:185-192. (Pubitemid 28277594)
20. O'Hare AM, Katz R, Shlipak MG, Cushman M, Newman AB. Mortality and cardiovascular risk across the ankle-arm index spectrum: Results from the Cardiovascular Health Study. Circulation. 2006;113:388-393. (Pubitemid 43803200)
21. Murabito JM, Evans JC, Nieto K, Larson MG, Levy D, Wilson PW. Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study. Am Heart J. 2002;143:961-965. (Pubitemid 34666884)
22. Zeymer U, Parhofer KG, Pittrow D, Binz C, Schwertfeger M, Limbourg T, Rother J. Risk factor profile, management and prognosis of patients with peripheral arterial disease with or without coronary artery disease: Results of the prospective German REACH registry cohort. Clin Res Cardiol. 2009;98:249-256.
23. Golledge J, Leicht A, Crowther RG, Clancy P, Spinks WL, Quigley F. Association of obesity and metabolic syndrome with the severity and outcome of intermittent claudication. J Vasc Surg. 2007;45:40-46. (Pubitemid 46043539)
24. Karason K, Peltonen M, Lindroos AK, Sjostrom L, Lonn L, Torgerson JS. Effort-related calf pain in the obese and long-term changes after surgical obesity treatment. Obes Res. 2005;13:137-145.
25. Stepp DW, Pollock DM, Frisbee JC. Low-flow vascular remodeling in the metabolic syndrome X. Am J Physiol Heart Circ Physiol. 2004;286: H964-H970. (Pubitemid 38248610)