메뉴 건너뛰기




Volumn 23, Issue 4, 2018, Pages 1051-1065

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

Author keywords

[No Author keywords available]

Indexed keywords

METHYL CPG BINDING PROTEIN 2; MICRORNA; MICRORNA 199; MICRORNA 214; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; MECP2 PROTEIN, HUMAN; MECP2 PROTEIN, MOUSE; MIRN199 MICRORNA, HUMAN; MIRN214 MICRORNA, HUMAN; SMALL INTERFERING RNA;

EID: 85044285349     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2017.86     Document Type: Article
Times cited : (201)

References (74)
  • 1
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11: 597-610.
    • (2010) Nat Rev Genet , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 2
    • 70450196816 scopus 로고    scopus 로고
    • MicroRNAs in brain development and physiology
    • Coolen M, Bally-Cuif L. MicroRNAs in brain development and physiology. Curr Opin Neurobiol 2009; 19: 461-470.
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 461-470
    • Coolen, M.1    Bally-Cuif, L.2
  • 3
    • 84866866864 scopus 로고    scopus 로고
    • The emerging role of microRNAs in schizophrenia and autism spectrum disorders
    • Mellios N, Sur M. The emerging role of microRNAs in schizophrenia and autism spectrum disorders. Front Psychiatry 2012; 3: 39.
    • (2012) Front Psychiatry , vol.3 , pp. 39
    • Mellios, N.1    Sur, M.2
  • 4
    • 80053224886 scopus 로고    scopus 로고
    • MIR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
    • Mellios N, Sugihara H, Castro J, Banerjee A, Le C, Kumar A et al. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity. Nat Neurosci 2011; 14: 1240-1242.
    • (2011) Nat Neurosci , vol.14 , pp. 1240-1242
    • Mellios, N.1    Sugihara, H.2    Castro, J.3    Banerjee, A.4    Le, C.5    Kumar, A.6
  • 5
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2
    • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2. Nat Genet 1999; 23: 185-188.
    • (1999) Nat Genet , vol.23 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 6
    • 84874936217 scopus 로고    scopus 로고
    • Mechanisms and therapeutic challenges in autism spectrum disorders: Insights from Rett syndrome
    • Castro J, Mellios N, Sur M. Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome. Curr Opin Neurol 2013; 26: 154-159.
    • (2013) Curr Opin Neurol , vol.26 , pp. 154-159
    • Castro, J.1    Mellios, N.2    Sur, M.3
  • 7
    • 84895740923 scopus 로고    scopus 로고
    • MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex
    • Cheng TL, Wang Z, Liao Q, Zhu Y, Zhou WH, Xu W et al. MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Dev Cell 2014; 28: 547-560.
    • (2014) Dev Cell , vol.28 , pp. 547-560
    • Cheng, T.L.1    Wang, Z.2    Liao, Q.3    Zhu, Y.4    Zhou, W.H.5    Xu, W.6
  • 8
    • 77950565107 scopus 로고    scopus 로고
    • Cross talk between microRNA and epigenetic regulation in adult neurogenesis
    • Szulwach KE, Li X, Smrt RD, Li Y, Luo Y, Lin L et al. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 2010; 189: 127-141.
    • (2010) J Cell Biol , vol.189 , pp. 127-141
    • Szulwach, K.E.1    Li, X.2    Smrt, R.D.3    Li, Y.4    Luo, Y.5    Lin, L.6
  • 10
    • 78149248751 scopus 로고    scopus 로고
    • Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome
    • Wu H, Tao J, Chen PJ, Shahab A, Ge W, Hart RP et al. Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 2010; 107: 18161-18166.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18161-18166
    • Wu, H.1    Tao, J.2    Chen, P.J.3    Shahab, A.4    Ge, W.5    Hart, R.P.6
  • 11
    • 1642367538 scopus 로고    scopus 로고
    • Rett syndrome: A prototypical neurodevelopmental disorder
    • Neul JL, Zoghbi HY. Rett syndrome: a prototypical neurodevelopmental disorder. Neuroscientist 2004; 10: 118-128.
    • (2004) Neuroscientist , vol.10 , pp. 118-128
    • Neul, J.L.1    Zoghbi, H.Y.2
  • 12
    • 17744368026 scopus 로고    scopus 로고
    • Is the early development of girls with Rett disorder really normal?
    • Einspieler C, Kerr AM, Prechtl HF. Is the early development of girls with Rett disorder really normal? Pediatr Res 2005; 57: 696-700.
    • (2005) Pediatr Res , vol.57 , pp. 696-700
    • Einspieler, C.1    Kerr, A.M.2    Prechtl, H.F.3
  • 13
    • 0029001282 scopus 로고
    • Early clinical signs in the Rett disorder
    • Kerr AM. Early clinical signs in the Rett disorder. Neuropediatrics 1995; 26: 67-71.
    • (1995) Neuropediatrics , vol.26 , pp. 67-71
    • Kerr, A.M.1
  • 15
    • 0035013739 scopus 로고    scopus 로고
    • MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin
    • Trappe R, Laccone F, Cobilanschi J, Meins M, Huppke P, Hanefeld F et al. MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin. Am J Hum Genet 2001; 68: 1093-1101.
    • (2001) Am J Hum Genet , vol.68 , pp. 1093-1101
    • Trappe, R.1    Laccone, F.2    Cobilanschi, J.3    Meins, M.4    Huppke, P.5    Hanefeld, F.6
  • 16
  • 18
    • 33847266846 scopus 로고    scopus 로고
    • Reversal of neurological defects in a mouse model of Rett syndrome
    • Guy J, Gan J, Selfridge J, Cobb S, Bird A. Reversal of neurological defects in a mouse model of Rett syndrome. Science 2007; 315: 1143-1147.
    • (2007) Science , vol.315 , pp. 1143-1147
    • Guy, J.1    Gan, J.2    Selfridge, J.3    Cobb, S.4    Bird, A.5
  • 19
    • 84896912072 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome
    • Khwaja OS, Ho E, Barnes KV, O'Leary HM, Pereira LM, Finkelstein Y et al. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc Natl Acad Sci USA 2014; 111: 4596-4601.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 4596-4601
    • Khwaja, O.S.1    Ho, E.2    Barnes, K.V.3    O'Leary, H.M.4    Pereira, L.M.5    Finkelstein, Y.6
  • 20
    • 84904012707 scopus 로고    scopus 로고
    • Beta2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome
    • Mellios N, Woodson J, Garcia RI, Crawford B, Sharma J, Sheridan SD et al. beta2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 2014; 111: 9947-9952.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 9947-9952
    • Mellios, N.1    Woodson, J.2    Garcia, R.I.3    Crawford, B.4    Sharma, J.5    Sheridan, S.D.6
  • 21
    • 20344405210 scopus 로고    scopus 로고
    • Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice
    • Fukuda T, Itoh M, Ichikawa T, Washiyama K, Goto Y. Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice. J Neuropathol Exp Neurol 2005; 64: 537-544.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 537-544
    • Fukuda, T.1    Itoh, M.2    Ichikawa, T.3    Washiyama, K.4    Goto, Y.5
  • 22
    • 7244243971 scopus 로고    scopus 로고
    • MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions
    • Kishi N, Macklis JD. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci 2004; 27: 306-321.
    • (2004) Mol Cell Neurosci , vol.27 , pp. 306-321
    • Kishi, N.1    Macklis, J.D.2
  • 23
    • 0037081840 scopus 로고    scopus 로고
    • Insight into Rett syndrome: MeCP2 levels display tissue-and cell-specific differences and correlate with neuronal maturation
    • Shahbazian MD, Antalffy B, Armstrong DL, Zoghbi HY. Insight into Rett syndrome: MeCP2 levels display tissue-and cell-specific differences and correlate with neuronal maturation. Hum Mol Genet 2002; 11: 115-124.
    • (2002) Hum Mol Genet , vol.11 , pp. 115-124
    • Shahbazian, M.D.1    Antalffy, B.2    Armstrong, D.L.3    Zoghbi, H.Y.4
  • 24
    • 0242539771 scopus 로고    scopus 로고
    • Survey of MeCP2 in the Rett syndrome and the non-Rett syndrome brain
    • Armstrong DD, Deguchi K, Antallfy B. Survey of MeCP2 in the Rett syndrome and the non-Rett syndrome brain. J Child Neurol 2003; 18: 683-687.
    • (2003) J Child Neurol , vol.18 , pp. 683-687
    • Armstrong, D.D.1    Deguchi, K.2    Antallfy, B.3
  • 26
    • 68549087008 scopus 로고    scopus 로고
    • Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2
    • Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K. Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. Exp Neurol 2009; 219: 104-111.
    • (2009) Exp Neurol , vol.219 , pp. 104-111
    • Tsujimura, K.1    Abematsu, M.2    Kohyama, J.3    Namihira, M.4    Nakashima, K.5
  • 27
    • 84974573964 scopus 로고    scopus 로고
    • Defects during Mecp2 null embryonic cortex development precede the onset of overt neurological symptoms
    • Bedogni F, Cobolli Gigli C, Pozzi D, Rossi RL, Scaramuzza L, Rossetti G et al. Defects during Mecp2 null embryonic cortex development precede the onset of overt neurological symptoms. Cereb Cortex 2016; 26: 2517-2529.
    • (2016) Cereb Cortex , vol.26 , pp. 2517-2529
    • Bedogni, F.1    Cobolli Gigli, C.2    Pozzi, D.3    Rossi, R.L.4    Scaramuzza, L.5    Rossetti, G.6
  • 28
    • 84870067243 scopus 로고    scopus 로고
    • Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations
    • Farra N, Zhang WB, Pasceri P, Eubanks JH, Salter MW, Ellis J. Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations. Mol Psychiatry 2012; 17: 1261-1271.
    • (2012) Mol Psychiatry , vol.17 , pp. 1261-1271
    • Farra, N.1    Zhang, W.B.2    Pasceri, P.3    Eubanks, J.H.4    Salter, M.W.5    Ellis, J.6
  • 29
    • 80052155858 scopus 로고    scopus 로고
    • Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
    • Kim KY, Hysolli E, Park IH. Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci USA 2011; 108: 14169-14174.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14169-14174
    • Kim, K.Y.1    Hysolli, E.2    Park, I.H.3
  • 30
    • 84885107449 scopus 로고    scopus 로고
    • Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons
    • Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Loven J et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell 2013; 13: 446-458.
    • (2013) Cell Stem Cell , vol.13 , pp. 446-458
    • Li, Y.1    Wang, H.2    Muffat, J.3    Cheng, A.W.4    Orlando, D.A.5    Loven, J.6
  • 31
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010; 143: 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6
  • 32
    • 84898441524 scopus 로고    scopus 로고
    • Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons
    • Williams EC, Zhong X, Mohamed A, Li R, Liu Y, Dong Q et al. Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Hum Mol Genet 2014; 23: 2968-2980.
    • (2014) Hum Mol Genet , vol.23 , pp. 2968-2980
    • Williams, E.C.1    Zhong, X.2    Mohamed, A.3    Li, R.4    Liu, Y.5    Dong, Q.6
  • 33
    • 84943351938 scopus 로고    scopus 로고
    • Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells
    • Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR et al. Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells. Biotechnol J 2015; 10: 1578-1588.
    • (2015) Biotechnol J , vol.10 , pp. 1578-1588
    • Fernandes, T.G.1    Duarte, S.T.2    Ghazvini, M.3    Gaspar, C.4    Santos, D.C.5    Porteira, A.R.6
  • 34
    • 38049187707 scopus 로고    scopus 로고
    • Reprogramming of human somatic cells to pluripotency with defined factors
    • Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008; 451: 141-146.
    • (2008) Nature , vol.451 , pp. 141-146
    • Park, I.H.1    Zhao, R.2    West, J.A.3    Yabuuchi, A.4    Huo, H.5    Ince, T.A.6
  • 35
    • 80053948646 scopus 로고    scopus 로고
    • Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
    • Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L et al. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS ONE 2011; 6: e26203.
    • (2011) PLoS ONE , vol.6 , pp. e26203
    • Sheridan, S.D.1    Theriault, K.M.2    Reis, S.A.3    Zhou, F.4    Madison, J.M.5    Daheron, L.6
  • 37
    • 84859767940 scopus 로고    scopus 로고
    • Analysis of embryoid bodies derived from human induced pluripotent stem cells as a means to assess pluripotency
    • Sheridan SD, Surampudi V, Rao RR. Analysis of embryoid bodies derived from human induced pluripotent stem cells as a means to assess pluripotency. Stem Cells Int 2012; 2012: 738910.
    • (2012) Stem Cells Int , vol.2012 , pp. 738910
    • Sheridan, S.D.1    Surampudi, V.2    Rao, R.R.3
  • 38
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
    • S471
    • Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat Neurosci 2012; 15: 477-486, S471.
    • (2012) Nat Neurosci , vol.15 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.4    Livesey, F.J.5
  • 41
    • 84901388868 scopus 로고    scopus 로고
    • Neural progenitors, neurogenesis and the evolution of the neocortex
    • Florio M, Huttner WB. Neural progenitors, neurogenesis and the evolution of the neocortex. Development 2014; 141: 2182-2194.
    • (2014) Development , vol.141 , pp. 2182-2194
    • Florio, M.1    Huttner, W.B.2
  • 42
    • 12144266963 scopus 로고    scopus 로고
    • Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    • Englund C, Fink A, Lau C, Pham D, Daza RA, Bulfone A et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J Neurosci 2005; 25: 247-251.
    • (2005) J Neurosci , vol.25 , pp. 247-251
    • Englund, C.1    Fink, A.2    Lau, C.3    Pham, D.4    Daza, R.A.5    Bulfone, A.6
  • 44
    • 84925443004 scopus 로고    scopus 로고
    • MIR-214 as a key hub that controls cancer networks: Small player, multiple functions
    • Penna E, Orso F, Taverna D. miR-214 as a key hub that controls cancer networks: small player, multiple functions. J Invest Dermatol 2015; 135: 960-969.
    • (2015) J Invest Dermatol , vol.135 , pp. 960-969
    • Penna, E.1    Orso, F.2    Taverna, D.3
  • 45
    • 79751484450 scopus 로고    scopus 로고
    • Identification of MIRNomes in human liver and hepatocellular carcinoma reveals MIR-199a/b-3p as therapeutic target for hepatocellular carcinoma
    • Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q et al. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 2011; 19: 232-243.
    • (2011) Cancer Cell , vol.19 , pp. 232-243
    • Hou, J.1    Lin, L.2    Zhou, W.3    Wang, Z.4    Ding, G.5    Dong, Q.6
  • 46
    • 84862903108 scopus 로고    scopus 로고
    • Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facialcutaneous and related syndromes
    • Pucilowska J, Puzerey PA, Karlo JC, Galan RF, Landreth GE. Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facialcutaneous and related syndromes. J Neurosci 2012; 32: 8663-8677.
    • (2012) J Neurosci , vol.32 , pp. 8663-8677
    • Pucilowska, J.1    Puzerey, P.A.2    Karlo, J.C.3    Galan, R.F.4    Landreth, G.E.5
  • 47
    • 49049085537 scopus 로고    scopus 로고
    • Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function
    • Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD et al. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 2008; 28: 6983-6995.
    • (2008) J Neurosci , vol.28 , pp. 6983-6995
    • Samuels, I.S.1    Karlo, J.C.2    Faruzzi, A.N.3    Pickering, K.4    Herrup, K.5    Sweatt, J.D.6
  • 48
    • 84876969224 scopus 로고    scopus 로고
    • AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development
    • Zhang J, Shemezis JR, McQuinn ER, Wang J, Sverdlov M, Chenn A. AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development. Neural Dev 2013; 8: 7.
    • (2013) Neural Dev , vol.8 , pp. 7
    • Zhang, J.1    Shemezis, J.R.2    McQuinn, E.R.3    Wang, J.4    Sverdlov, M.5    Chenn, A.6
  • 49
    • 77953545864 scopus 로고    scopus 로고
    • The role of MeCP2 in brain development and neurodevelopmental disorders
    • Gonzales ML, LaSalle JM. The role of MeCP2 in brain development and neurodevelopmental disorders. Curr Psychiatry Rep 2010; 12: 127-134.
    • (2010) Curr Psychiatry Rep , vol.12 , pp. 127-134
    • Gonzales, M.L.1    LaSalle, J.M.2
  • 52
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • Chen RZ, Akbarian S, Tudor M, Jaenisch R. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 2001; 27: 327-331.
    • (2001) Nat Genet , vol.27 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 53
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy J, Hendrich B, Holmes M, Martin JE, Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 2001; 27: 322-326.
    • (2001) Nat Genet , vol.27 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 55
    • 31444434393 scopus 로고    scopus 로고
    • The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
    • Chang Q, Khare G, Dani V, Nelson S, Jaenisch R. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 2006; 49: 341-348.
    • (2006) Neuron , vol.49 , pp. 341-348
    • Chang, Q.1    Khare, G.2    Dani, V.3    Nelson, S.4    Jaenisch, R.5
  • 56
    • 35148840586 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome
    • Ogier M, Wang H, Hong E, Wang Q, Greenberg ME, Katz DM. Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. J Neurosci 2007; 27: 10912-10917.
    • (2007) J Neurosci , vol.27 , pp. 10912-10917
    • Ogier, M.1    Wang, H.2    Hong, E.3    Wang, Q.4    Greenberg, M.E.5    Katz, D.M.6
  • 57
    • 84863025204 scopus 로고    scopus 로고
    • A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome
    • Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q et al. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci 2012; 32: 1803-1810.
    • (2012) J Neurosci , vol.32 , pp. 1803-1810
    • Schmid, D.A.1    Yang, T.2    Ogier, M.3    Adams, I.4    Mirakhur, Y.5    Wang, Q.6
  • 59
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008; 454: 56-61.
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 60
    • 0029059624 scopus 로고
    • Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome
    • Bauman ML, Kemper TL, Arin DM. Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome. Neurology 1995; 45: 1581-1586.
    • (1995) Neurology , vol.45 , pp. 1581-1586
    • Bauman, M.L.1    Kemper, T.L.2    Arin, D.M.3
  • 61
    • 0035201049 scopus 로고    scopus 로고
    • Rett syndrome neuropathology review 2000
    • Armstrong DD. Rett syndrome neuropathology review 2000. Brain Dev 2001; 23 (Suppl 1): S72-S76.
    • (2001) Brain Dev , vol.23 , pp. S72-S76
    • Armstrong, D.D.1
  • 63
    • 84937212591 scopus 로고    scopus 로고
    • FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
    • Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L et al. FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders. Cell 2015; 162: 375-390.
    • (2015) Cell , vol.162 , pp. 375-390
    • Mariani, J.1    Coppola, G.2    Zhang, P.3    Abyzov, A.4    Provini, L.5    Tomasini, L.6
  • 65
    • 84959361431 scopus 로고    scopus 로고
    • Loss of MeCP2 in parvalbuminand somatostatin-expressing neurons in mice leads to distinct Rett syndrome-like phenotypes
    • Ito-Ishida A, Ure K, Chen H, Swann JW, Zoghbi HY. Loss of MeCP2 in parvalbuminand somatostatin-expressing neurons in mice leads to distinct Rett syndrome-like phenotypes. Neuron 2015; 88: 651-658.
    • (2015) Neuron , vol.88 , pp. 651-658
    • Ito-Ishida, A.1    Ure, K.2    Chen, H.3    Swann, J.W.4    Zoghbi, H.Y.5
  • 66
    • 84857683479 scopus 로고    scopus 로고
    • An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model
    • Selvamani A, Sathyan P, Miranda RC, Sohrabji F. An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS ONE 2012; 7: e32662.
    • (2012) PLoS ONE , vol.7 , pp. e32662
    • Selvamani, A.1    Sathyan, P.2    Miranda, R.C.3    Sohrabji, F.4
  • 68
    • 84942832697 scopus 로고    scopus 로고
    • MIR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett syndrome phenotypes
    • Tsujimura K, Irie K, Nakashima H, Egashira Y, Fukao Y, Fujiwara M et al. miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett syndrome phenotypes. Cell Rep 2015; 12: 1887-1901.
    • (2015) Cell Rep , vol.12 , pp. 1887-1901
    • Tsujimura, K.1    Irie, K.2    Nakashima, H.3    Egashira, Y.4    Fukao, Y.5    Fujiwara, M.6
  • 69
    • 33749081269 scopus 로고    scopus 로고
    • Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males
    • del Gaudio D, Fang P, Scaglia F, Ward PA, Craigen WJ, Glaze DG et al. Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males. Genet Med 2006; 8: 784-792.
    • (2006) Genet Med , vol.8 , pp. 784-792
    • Del Gaudio, D.1    Fang, P.2    Scaglia, F.3    Ward, P.A.4    Craigen, W.J.5    Glaze, D.G.6
  • 70
    • 23944503759 scopus 로고    scopus 로고
    • Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males
    • Van Esch H, Bauters M, Ignatius J, Jansen M, Raynaud M, Hollanders K et al. Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am J Hum Genet 2005; 77: 442-453.
    • (2005) Am J Hum Genet , vol.77 , pp. 442-453
    • Van Esch, H.1    Bauters, M.2    Ignatius, J.3    Jansen, M.4    Raynaud, M.5    Hollanders, K.6
  • 72
    • 79952032711 scopus 로고    scopus 로고
    • Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model
    • Ricciardi S, Boggio EM, Grosso S, Lonetti G, Forlani G, Stefanelli G et al. Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum Mol Genet 2011; 20: 1182-1196.
    • (2011) Hum Mol Genet , vol.20 , pp. 1182-1196
    • Ricciardi, S.1    Boggio, E.M.2    Grosso, S.3    Lonetti, G.4    Forlani, G.5    Stefanelli, G.6
  • 73
    • 84931577685 scopus 로고    scopus 로고
    • Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism
    • Casanova EL, Casanova MF. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Front Cell Neurosci 2014; 8: 397.
    • (2014) Front Cell Neurosci , vol.8 , pp. 397
    • Casanova, E.L.1    Casanova, M.F.2
  • 74
    • 84881193129 scopus 로고    scopus 로고
    • Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network
    • Gulsuner S, Walsh T, Watts AC, Lee MK, Thornton AM, Casadei S et al. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell 2013; 154: 518-529.
    • (2013) Cell , vol.154 , pp. 518-529
    • Gulsuner, S.1    Walsh, T.2    Watts, A.C.3    Lee, M.K.4    Thornton, A.M.5    Casadei, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.