De novo synthesis of the sedative valerenic acid in Saccharomyces cerevisiae

Metabolic Engineering

Volumn 47, Issue , 2018, Pages 94-101

  Wong, Jeff ^a,b,c,e   d'Espaux, Leo ^b,c,e   Dev, Ishaan ^b,c,d   van der Horst, Cas ^b,c   Keasling, Jay ^b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOINT BIOENERGY INSTITUTE   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Demetrix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; OLEFINS;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; BIOSYNTHETIC PATHWAY; DE NOVO SYNTHESIS; MICROBIAL PRODUCTION; SEQUENCE HOMOLOGY; TISSUE-SPECIFIC EXPRESSION; VALERIANA OFFICINALIS;

YEAST;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALKADIENE; CYTOCHROME P450; OXIDOREDUCTASE; SEDATIVE AGENT; SYNTHETASE; TERPENOID; UNCLASSIFIED DRUG; VALERENA 4,7(11) DIENE; VALERENA 4,7(11) DIENE OXIDASE; VALERENA 4,7(11) DIENE SYNTHASE; VALERENIC ACID; HYPNOTIC SEDATIVE AGENT; INDENE DERIVATIVE; PLANT PROTEIN; SESQUITERPENE; VALERIAN;

ARTICLE; BIOSYNTHESIS; DRUG SYNTHESIS; FERMENTATION; METABOLIC ENGINEERING; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SCALE UP; SEQUENCE HOMOLOGY; TISSUE SPECIFICITY; VALERIANA OFFICINALIS; ENZYMOLOGY; GENETICS; METABOLISM;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CYTOCHROME P-450 ENZYME SYSTEM; HYPNOTICS AND SEDATIVES; INDENES; PLANT PROTEINS; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; VALERIAN;

EID: 85044089612     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2018.03.005     Document Type: Article

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