SCOPUS 정보 검색 플랫폼

Synlett

Volumn , Issue 11, 2009, Pages 1769-1772

Total synthesis of valerenic acid

(3) Kopp, Sascha a Schweizer, W Bernd a Altmann, Karl Heinz a

a ETH ZURICH (Switzerland)

Author keywords

GABAA receptor; Microwave assisted Wittig reaction; Natural product; Total synthesis; Valerenic acid

Indexed keywords

2 CYCLOHEXENONE; ANXIOLYTIC AGENT; KETONE DERIVATIVE; PULEGONE; UNCLASSIFIED DRUG; VALERENIC ACID; VALERIAN;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; MICROWAVE RADIATION; REDUCTION; STEREOCHEMISTRY; SUBSTITUTION REACTION; VALERIANA OFFICINALIS; WITTIG REACTION; X RAY CRYSTALLOGRAPHY;

EID: 67649967738 PISSN: 09365214 EISSN: 14372096 Source Type: Journal
DOI: 10.1055/s-0029-1217378 Document Type: Article

Times cited : (16)

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- Preparation and Analytical Data of Compound 1 To a solution of ethyl ester 14 (32 mg, 0.12 mmol) in 2-PrOH-H2O (5:1, 0.6 mL) was added LiOH (6 mg, 0.24 mmol, and the mixture was heated to 40°C for 10 h. The solution was concentrated and the residue directly purified by FC (hexane-EtOAc, 5:1, 1% formic acid) to give 29 mg (97, of valerenic acid (1) as a white solid. Crystals suitable for X-ray crystallography were obtained from hexane-MeOH-Et2O. Mp 138.5-139.5°C (lit, 140-142°C).10 [α]D25 -13.0 (c 2.15, CHCl3, α]D20 -119.8 (c 2.50, EtOH, lit, α]D20 -120.0, EtOH, 10 HRMS (EI, m/z calcd for C15H22O 2: 234.1614; found [M, 234.1616. 1H NMR (400 MHz, CDCl3, 25°C, δ, 7.16 (d, J, 9.8 Hz, 1 H, 3.58-3.52 m
- -1.

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- Natural valerenic acid was purchased from extrasynthèse (France).

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.