Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism

Journal of Biological Chemistry

Volumn 286, Issue 24, 2011, Pages 21601-21611

  Ikezawa, Nobuhiro ^a   Göpfert, Jens Christian ^b   Nguyen, Don Trinh ^a   Kim, Soo Un ^c   O'Maille, Paul E ^d   Spring, Otmar ^b   Ro, Dae Kyun ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF HOHENHEIM   (Germany)

^c Seoul National University   (South Korea)

^d JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

A-CARBON; ASTERACEAE; CYTOCHROME P450; DE NOVO SYNTHESIS; GERMACRENE; HOMOLOGY MODELS; HYDROXYLASES; LACTONE RINGS; LACTONIZATION; MONOOXYGENASES; NATURAL PRODUCTS; REGIO-SELECTIVE; SESQUITERPENE LACTONES; STEREO-SELECTIVE; SYNTHASES; TERPENOIDS; YEAST STRAIN;

BIOLOGY; CARBOXYLIC ACIDS; HYDROXYLATION; STEREOSELECTIVITY; YEAST;

GALLIUM ALLOYS;

6ALPHA HYDROXYGERMACRENE A ACID; COSTUNOLIDE; COSTUNOLIDE SYNTHETASE; CYTOCHROME P450; GERMACRENE A ACID; GERMACRENE A ACID 8BETA HYDROXYLASE; NATURAL PRODUCT; OXYGENASE; PROTEIN CYP71BL1; PROTEIN CYP71BL2; RECOMBINANT ENZYME; SESQUITERPENE LACTONE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CYP71BL1 GENE; CYP71BL2 GENE; ENZYME ISOLATION; ENZYME SPECIFICITY; HYDROXYLATION; LETTUCE; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYTOCHEMISTRY; PLANT GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; SUNFLOWER; TRICHOME;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; GENE LIBRARY; HELIANTHUS; LACTONES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLANT PROTEINS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SESQUITERPENES; SESQUITERPENES, GERMACRANE; SOLVENTS; STEREOISOMERISM;

ASTERACEAE; HELIANTHUS; LACTUCA;

EID: 79958702874     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.216804     Document Type: Article

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