GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 174-181

  Benke, Dietmar ^a   Barberis, Andrea ^a   Kopp, Sascha ^b   Altmann, Karl Heinz ^b   Schubiger, Monika ^a   Vogt, Kaspar E ^a   Rudolph, Uwe ^a   Möhler, Hanns ^a,b,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c Swiss Federal Institute of Technology Collegium Helveticum   (Switzerland)

Author keywords

Anxiety; GABAA receptors; Sedation; Valerenic acid; Valeriana officinalis

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; MUSCIMOL; O METHYLVALERENOL; UNCLASSIFIED DRUG; VALERENAL; VALERENIC ACID; VALERENOL; VALERIAN;

ALLOSTERISM; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING COMPETITION; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; LIGHT DARK CYCLE; MAZE TEST; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SEDATION; TRANQUILIZING ACTIVITY;

ALLOSTERIC SITE; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BRAIN; CELL LINE, TRANSFORMED; CHOICE BEHAVIOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HUMANS; INDENES; MAZE LEARNING; MEMBRANE POTENTIALS; MICE; MICE, MUTANT STRAINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; PLANT EXTRACTS; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; SESQUITERPENES; TRITIUM;

EID: 58049130013     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.013     Document Type: Article

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