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Volumn 14, Issue , 2014, Pages

The anxiolytic effects of a Valerian extract is based on Valerenic acid

Author keywords

Anxiety; Binding; Elevated plus maze; Valerenic acid; Valerian extract

Indexed keywords

4 AMINOBUTYRIC ACID; ACETOXY VALERENIC ACID; CHLORDIAZEPOXIDE; DIAZEPAM; FLUNITRAZEPAM; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; VALERENIC ACID; VALERIAN; 4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; BENZODIAZEPINE RECEPTOR;

EID: 84904772554     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-267     Document Type: Article
Times cited : (54)

References (21)
  • 1
    • 58049130013 scopus 로고    scopus 로고
    • GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts
    • Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 2009, 56(1):174-181.
    • (2009) Neuropharmacology , vol.56 , Issue.1 , pp. 174-181
    • Benke, D.1    Barberis, A.2    Kopp, S.3    Altmann, K.H.4    Schubiger, M.5    Vogt, K.E.6    Rudolph, U.7    Möhler, H.8
  • 2
    • 77955791538 scopus 로고    scopus 로고
    • Valerenic acid derivatives as novel subunit-selective ligands - in vitro and in vivo characterization
    • 10.1111/j.1476-5381.2010.00865.x, 2962817, 20718740
    • Khom S, Strommeier B, Ramharter J, Schwarz T, Schwarzer C, Erker T, Ecker GF, Mulzer J, Hering S. Valerenic acid derivatives as novel subunit-selective ligands - in vitro and in vivo characterization. Br J Pharmacol 2010, 161(1):65-78. 10.1111/j.1476-5381.2010.00865.x, 2962817, 20718740.
    • (2010) Br J Pharmacol , vol.161 , Issue.1 , pp. 65-78
    • Khom, S.1    Strommeier, B.2    Ramharter, J.3    Schwarz, T.4    Schwarzer, C.5    Erker, T.6    Ecker, G.F.7    Mulzer, J.8    Hering, S.9
  • 3
    • 77952292512 scopus 로고    scopus 로고
    • Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats
    • 10.1016/j.phymed.2009.10.020, 20042323
    • Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine 2010, 17:674-678. 10.1016/j.phymed.2009.10.020, 20042323.
    • (2010) Phytomedicine , vol.17 , pp. 674-678
    • Murphy, K.1    Kubin, Z.J.2    Shepherd, J.N.3    Ettinger, R.H.4
  • 4
    • 34547229341 scopus 로고    scopus 로고
    • Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity
    • 10.1016/j.neuropharm.2007.04.018, 17585957
    • Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacology 2007, 53(1):178-187. 10.1016/j.neuropharm.2007.04.018, 17585957.
    • (2007) Neuropharmacology , vol.53 , Issue.1 , pp. 178-187
    • Khom, S.1    Baburin, I.2    Timin, E.3    Hohaus, A.4    Trauner, G.5    Kopp, B.6    Hering, S.7
  • 5
    • 39149114366 scopus 로고    scopus 로고
    • Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid
    • Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med 2007, 74:19-24.
    • (2007) Planta Med , vol.74 , pp. 19-24
    • Trauner, G.1    Khom, S.2    Baburin, I.3    Benedek, B.4    Hering, S.5    Kopp, B.6
  • 6
    • 84866734716 scopus 로고    scopus 로고
    • Valerian extract characterized by high valerenic acid and low azetoxy valerenic acid contents demonstrates anxiolytic activity
    • 10.1016/j.phymed.2012.08.003, 22944521
    • Felgentreff F, Becker A, Meier B, Brattström A. Valerian extract characterized by high valerenic acid and low azetoxy valerenic acid contents demonstrates anxiolytic activity. Phytomedicine 2012, 19:1216-1222. 10.1016/j.phymed.2012.08.003, 22944521.
    • (2012) Phytomedicine , vol.19 , pp. 1216-1222
    • Felgentreff, F.1    Becker, A.2    Meier, B.3    Brattström, A.4
  • 7
    • 33646853535 scopus 로고    scopus 로고
    • Chemical fingerprinting of valerian species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection
    • Navarrete A, Avula B, Choi YW. Chemical fingerprinting of valerian species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. J AOAC Int 2006, 89:8-18.
    • (2006) J AOAC Int , vol.89 , pp. 8-18
    • Navarrete, A.1    Avula, B.2    Choi, Y.W.3
  • 8
    • 8944259907 scopus 로고    scopus 로고
    • Effects of GABA agonists and antagonists on temperature-sensitive neurons in the rat hypothalamus
    • 1160625, 8814617
    • Yakimova KS, Sann H, Schmid HA, Pierau FK. Effects of GABA agonists and antagonists on temperature-sensitive neurons in the rat hypothalamus. J Physiol 1996, 494:217-230. 1160625, 8814617.
    • (1996) J Physiol , vol.494 , pp. 217-230
    • Yakimova, K.S.1    Sann, H.2    Schmid, H.A.3    Pierau, F.K.4
  • 9
    • 0024471996 scopus 로고    scopus 로고
    • Involvement of GABAA receptor sites in diazepam induced hypothermia
    • Zarrindast MR, Dibayan M. Involvement of GABAA receptor sites in diazepam induced hypothermia. Gen Pharmacol 1998, 20:855-859.
    • (1998) Gen Pharmacol , vol.20 , pp. 855-859
    • Zarrindast, M.R.1    Dibayan, M.2
  • 10
    • 80052792648 scopus 로고    scopus 로고
    • Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats
    • 10.1007/s00726-010-0754-5, 20878340
    • Nikolov RP, Yakimova KS. Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats. Amino Acids 2011, 40(5):1441-1445. 10.1007/s00726-010-0754-5, 20878340.
    • (2011) Amino Acids , vol.40 , Issue.5 , pp. 1441-1445
    • Nikolov, R.P.1    Yakimova, K.S.2
  • 11
    • 0030733915 scopus 로고    scopus 로고
    • Animal models of anxiety: where next?
    • 10.1097/00008877-199711000-00003, 9832964
    • Rodgers RJ. Animal models of anxiety: where next?. Behav Pharmacol 1997, 8:477-496. 10.1097/00008877-199711000-00003, 9832964.
    • (1997) Behav Pharmacol , vol.8 , pp. 477-496
    • Rodgers, R.J.1
  • 12
    • 3042570960 scopus 로고    scopus 로고
    • Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans
    • Goppel M, Franz G. Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. Pharmazie 2003, 59:446-452.
    • (2003) Pharmazie , vol.59 , pp. 446-452
    • Goppel, M.1    Franz, G.2
  • 13
    • 1642575173 scopus 로고    scopus 로고
    • Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
    • 10.1016/j.pbb.2003.12.003, 14751470
    • Fernández S, Wasowski C, Paladini AC, Marder M. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol Biochem Behav 2004, 77(2):399-404. 10.1016/j.pbb.2003.12.003, 14751470.
    • (2004) Pharmacol Biochem Behav , vol.77 , Issue.2 , pp. 399-404
    • Fernández, S.1    Wasowski, C.2    Paladini, A.C.3    Marder, M.4
  • 14
    • 0041696943 scopus 로고    scopus 로고
    • 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
    • 10.1016/S0091-3057(03)00121-7, 12895671
    • Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 2003, 75(3):537-545. 10.1016/S0091-3057(03)00121-7, 12895671.
    • (2003) Pharmacol Biochem Behav , vol.75 , Issue.3 , pp. 537-545
    • Marder, M.1    Viola, H.2    Wasowski, C.3    Fernández, S.4    Medina, J.H.5    Paladini, A.C.6
  • 15
    • 1642541871 scopus 로고    scopus 로고
    • The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity
    • Yuan CS, Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anaesth Analg 2004, 98(2):353-358.
    • (2004) Anaesth Analg , vol.98 , Issue.2 , pp. 353-358
    • Yuan, C.S.1    Mehendale, S.2    Xiao, Y.3    Aung, H.H.4    Xie, J.T.5    Ang-Lee, M.K.6
  • 16
    • 84860118464 scopus 로고    scopus 로고
    • Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations
    • 10.1055/s-0031-1298301, 22411722
    • Sampath C, Haug K, Thanel S, Hamburger M, Derendorf H, Frye R, Butterweck V. Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. Planta Med 2012, 78:575-581. 10.1055/s-0031-1298301, 22411722.
    • (2012) Planta Med , vol.78 , pp. 575-581
    • Sampath, C.1    Haug, K.2    Thanel, S.3    Hamburger, M.4    Derendorf, H.5    Frye, R.6    Butterweck, V.7
  • 17
    • 36549072427 scopus 로고    scopus 로고
    • Effects of traditionally used anxiolytic botanicals on enzymes of the γ-aminobutyric acid (GABA)
    • 10.1139/Y07-083, 18066140
    • Awad R, Levac P, Cybulska P, Merali Z, Trudeau VL, Arnason JT. Effects of traditionally used anxiolytic botanicals on enzymes of the γ-aminobutyric acid (GABA). Can J Physiol Pharmacol 2007, 85:933-942. 10.1139/Y07-083, 18066140.
    • (2007) Can J Physiol Pharmacol , vol.85 , pp. 933-942
    • Awad, R.1    Levac, P.2    Cybulska, P.3    Merali, Z.4    Trudeau, V.L.5    Arnason, J.T.6
  • 20
    • 54049137689 scopus 로고    scopus 로고
    • Internationale Union of Pharmacology. LXX. Subtypes of γ-aminobutyric acid A receptors: classification on the basis of subunit composition, pharmacology, and function. Update
    • Olsen RW, Sieghart W. Internationale Union of Pharmacology. LXX. Subtypes of γ-aminobutyric acid A receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 2008, 60(3):242-260.
    • (2008) Pharmacol Rev , vol.60 , Issue.3 , pp. 242-260
    • Olsen, R.W.1    Sieghart, W.2
  • 21
    • 78751497286 scopus 로고    scopus 로고
    • The GABAA receptor α+β-interface: a novel target for subtype selective drugs
    • 10.1523/JNEUROSCI.5012-10.2011, 3182524, 21248110
    • Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W. The GABAA receptor α+β-interface: a novel target for subtype selective drugs. J Neurosci 2011, 31:870-877. 10.1523/JNEUROSCI.5012-10.2011, 3182524, 21248110.
    • (2011) J Neurosci , vol.31 , pp. 870-877
    • Ramerstorfer, J.1    Furtmüller, R.2    Sarto-Jackson, I.3    Varagic, Z.4    Sieghart, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.