Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 34, 2016, Pages E5082-E5089

  Luo, Dan ^a   Callari, Roberta ^b   Hamberger, Britta ^a   Wubshet, Sileshi Gizachew ^c   Nielsen, Morten T ^a   Andersen Ranberg, Johan ^a,d   Hallström, Björn M ^e   Cozzi, Federico ^a   Heider, Harald ^b   Møller, Birger Lindberg ^a,d   Staerk, Dan ^c   Hamberger, Björn ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Evolva AS   (Switzerland)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Center for Synthetic Biology bioSYNergy   (Denmark)

^e ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Nonconventional cyclization; Regio specific oxidation; Terpenoid biosynthesis; Transcriptomic analysis

Indexed keywords

ALCOHOL DEHYDROGENASE; CASBENE; CYTOCHROME P450; CYTOCHROME P450 71D445; CYTOCHROME P450 726A27; DITERPENE; INGENOL MEBUTATE; UNCLASSIFIED DRUG; 3-INGENYL ANGELATE; ANTINEOPLASTIC AGENT; ISOENZYME; PHENYLPROPIONIC ACID DERIVATIVE; PLANT PROTEIN; RECOMBINANT PROTEIN; TRANSCRIPTOME; VEGETABLE OIL;

ARTICLE; BIOSYNTHESIS; CYCLIZATION; DEHYDROGENATION; EUPHORBIA; EUPHORBIA LATHYRIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; OXYGENATION; PLANT SEED; PRIORITY JOURNAL; TRANSCRIPTOMICS; CHEMISTRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MOLECULAR CLONING; OXIDATION REDUCTION REACTION; TOBACCO;

ALCOHOL DEHYDROGENASE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CLONING, MOLECULAR; CYCLIZATION; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; EUPHORBIA; GENE EXPRESSION; GENE EXPRESSION PROFILING; ISOENZYMES; OXIDATION-REDUCTION; PHENYLPROPIONATES; PLANT OILS; PLANT PROTEINS; RECOMBINANT PROTEINS; SEEDS; TOBACCO; TRANSCRIPTOME;

EID: 84983683560     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1607504113     Document Type: Article

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