S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

Cell Reports

Volumn 22, Issue 9, 2018, Pages 2431-2441

  Cohen, Taylor S ^a   Boland, Michelle L ^a   Boland, Brandon B ^a   Takahashi, Virginia ^a   Tovchigrechko, Andrey ^a   Lee, Young ^a   Wilde, Aimee D ^b   Mazaitis, Mark J ^c   Jones Nelson, Omari ^a   Tkaczyk, Christine ^a   Raja, Rajiv ^a   Stover, C Kendall ^a   Sellman, Bret R ^a  

^a MEDIMMUNE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Nascent Studio   (United States)

Author keywords

alpha toxin; bacterial infection; mitochondria; monoclonal antibody; NLRP3 inflammasome; pneumonia; S. aureus

Indexed keywords

ALPHA TOXIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); BACTERIAL TOXIN; HEMOLYSIN; STAPHYLOCOCCAL ALPHA-TOXIN;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE EVASION; IN VIVO STUDY; MACROPHAGE FUNCTION; MALE; MITOCHONDRION; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; SURVIVAL; ANIMAL; C57BL MOUSE; MACROPHAGE; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; PROTEIN TRANSPORT; SERODIAGNOSIS;

ANIMALS; BACTERIAL TOXINS; CASPASE 1; ELECTRON TRANSPORT COMPLEX II; FEMALE; HEMOLYSIN PROTEINS; HUMANS; IMMUNE EVASION; INTERLEUKIN-18; INTERLEUKIN-1BETA; MACROPHAGES; MICE, INBRED C57BL; MICROBIAL VIABILITY; MITOCHONDRIA; MONOCYTES; NEUTRALIZATION TESTS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; STAPHYLOCOCCUS AUREUS;

EID: 85042608153     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.02.027     Document Type: Article

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