Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

PLoS Pathogens

Volumn 11, Issue 6, 2015, Pages

  Melehani, Jason H ^a   James, David B A ^b   DuMont, Ashley L ^b   Torres, Victor J ^b   Duncan, Joseph A ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD14 ANTIGEN; CRYOPYRIN; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEUKOCIDIN; BACTERIAL PROTEIN; CARRIER PROTEIN; CYTOSKELETON PROTEIN; LEUKOCIDIN AB, STAPHYLOCOCCUS AUREUS; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN; VIRULENCE FACTOR;

ADIPOSE DERIVED STEM CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY ASSAY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOBLOTTING; MONOCYTE; NECROSIS; PROPIDIUM IODIDE ASSAY; PROTEIN EXPRESSION ASSAY; STAPHYLOCOCCUS INFECTION; TRANSMISSION ELECTRON MICROSCOPY; EXTRACELLULAR SPACE; HOST PARASITE INTERACTION; IMMUNOASSAY; INTRACELLULAR SPACE; METABOLISM; PHYSIOLOGY; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; CARRIER PROTEINS; CYTOSKELETAL PROTEINS; EXTRACELLULAR SPACE; FLOW CYTOMETRY; HOST-PARASITE INTERACTIONS; HUMANS; IMMUNOASSAY; IMMUNOBLOTTING; INTRACELLULAR SPACE; LEUKOCIDINS; MICROSCOPY, ELECTRON, TRANSMISSION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS;

EID: 84936769144     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004970     Document Type: Article

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