Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Nature Immunology

Volumn 16, Issue 11, 2015, Pages 1142-1152

  Geng, Jing ^a   Sun, Xiufeng ^a   Wang, Ping ^a   Zhang, Shihao ^a   Wang, Xiaozhen ^a   Wu, Hongtan ^a   Hong, Lixin ^a   Xie, Changchuan ^a   Li, Xun ^b   Zhao, Hao ^a   Liu, Qingxu ^a   Jiang, Mingting ^a   Chen, Qinghua ^a   Zhang, Jinjia ^a   Li, Yang ^a   Song, Siyang ^a   Wang, Hong Rui ^a   Zhou, Rongbin ^c   Johnso, Randy L ^d   Chien, Kun Yi ^e   Lin, Sheng Cai ^a   Han, Jiahuai ^a   Avruch, Joseph ^f,g   Chen, Lanfen ^a   Zhou, Dawang ^a   more..

^a XIAMEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d UNIVERSITY OF TEXAS   (United States)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^f HARVARD MEDICAL SCHOOL   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; CRE RECOMBINASE; INTERLEUKIN 6; LIPOTEICHOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; MST1 PROTEIN; MST2 PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOTRANSFERASE; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; RESIQUIMOD; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 2; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ARHGDIB PROTEIN, MOUSE; ECSIT PROTEIN, MOUSE; MINOR HISTOCOMPATIBILITY ANTIGEN; MST2 PROTEIN, MOUSE; PROTEIN KINASE C ALPHA; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STK3 PROTEIN, MOUSE; STK4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL PERITONITIS; BACTERICIDAL ACTIVITY; BINDING SITE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION; ENZYME PHOSPHORYLATION; EXTRAMEDULLARY HEMATOPOIESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INNATE IMMUNITY; INTRACELLULAR KILLING; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PHAGOCYTE; PHAGOCYTIC INDUCTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SITE DIRECTED MUTAGENESIS; UBIQUITINATION; ANIMAL; BACTERIAL INFECTIONS; C57BL MOUSE; CELL LINE; DEFICIENCY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; MITOCHONDRION; PHAGOSOME; SEPSIS; SERUM BACTERICIDAL ACTIVITY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BACTERIAL INFECTIONS; BLOOD BACTERICIDAL ACTIVITY; CELL LINE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MINOR HISTOCOMPATIBILITY ANTIGENS; MITOCHONDRIA; PHAGOCYTES; PHAGOSOMES; PROTEIN KINASE C-ALPHA; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR BETA; SEPSIS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTORS; UBIQUITINATION;

EID: 84944897402     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3268     Document Type: Article

References (50)

1. West A.P., Koblansky A.A., & Ghosh S. Recognition and signaling by toll-like receptors. Annu. Rev. Cell Dev. Biol. 22, 409-437 (2006
2. Beutler B., et al. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24, 353-389 (2006
3. Lambeth J.D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4, 181-189 (2004
4. Bedard K., & Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245-313 (2007
5. Bokoch G.M., & Diebold B.A. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100, 2692-2696 (2002
6. Mehta D., Rahman A., & Malik A.B. Protein kinase C-α signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J. Biol. Chem. 276, 22614-22620 (2001
7. DerMardirossian C., Schnelzer A., & Bokoch G.M. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol. Cell 15, 117-127 (2004
8. Ambruso D.R., et al. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc. Natl. Acad. Sci. USA 97, 4654-4659 (2000
9. Williams D.A., et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood 96, 1646-1654 (2000
10. Gu Y., et al. Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. J. Biol. Chem. 276, 15929-15938 (2001
11. West A.P., et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472, 476-480 (2011
12. Sena L.A., & Chandel N.S. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48, 158-167 (2012
13. Emre Y., et al. Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem. J. 402, 271-278 (2007
14. Wu W., Hsu Y.M., Bi L., Songyang Z., & Lin X. CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat. Immunol. 10, 1208-1214 (2009
15. Arsenijevic D., et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26, 435-439 (2000
16. Bulua A.C., et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J. Exp. Med. 208, 519-533 (2011
17. Creasy C.L., Ambrose D.M., & Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271, 21049-21053 (1996
18. Creasy C.L., & Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270, 21695-21700 (1995
19. Rawat S.J., & Chernoff J. Regulation of mammalian Ste20 (Mst) kinases. Trends Biochem. Sci. 40, 149-156 (2015
20. Avruch J., et al. Protein kinases of the Hippo pathway: regulation and substrates. Semin. Cell Dev. Biol. 23, 770-784 (2012
21. Zhou D., et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16, 425-438 (2009
22. O'Neill E., Rushworth L., Baccarini M., & Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306, 2267-2270 (2004
23. Del Re D.P., et al. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol. Cell 54, 639-650 (2014
24. Maejima Y., et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat. Med. 19, 1478-1488 (2013
25. Pan D. The hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505 (2010
26. Harvey K.F., Zhang X., & Thomas D.M. The Hippo pathway and human cancer. Nat. Rev. Cancer 13, 246-257 (2013
27. Yu F.X., & Guan K.L. The Hippo pathway: regulators and regulations. Genes Dev. 27, 355-371 (2013
28. Johnson R., & Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat. Rev. Drug Discov. 13, 63-79 (2014
29. Zeng Q., & Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 13, 188-192 (2008
30. Zhou D., et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc. Natl. Acad. Sci. USA 108, E1312-E1320 (2011
31. Abdollahpour H., et al. The phenotype of human STK4 deficiency. Blood 119, 3450-3457 (2012
32. Nehme N.T., et al. MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood 119, 3458-3468 (2012
33. Du X., et al. Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. J. Immunol. 192, 1525-1535 (2014
34. Dong Y., et al. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J. Immunol. 183, 3865-3872 (2009
35. Ueda Y., et al. Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat. Commun. 3, 1098 (2012
36. Katagiri K., Imamura M., & Kinashi T. Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat. Immunol. 7, 919-928 (2006
37. Katagiri K., Maeda A., Shimonaka M., & Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat. Immunol. 4, 741-748 (2003
38. Katagiri K., et al. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat. Immunol. 5, 1045-1051 (2004
39. Zhou D., et al. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells. Proc. Natl. Acad. Sci. USA 105, 20321-20326 (2008
40. Mou F., et al. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J. Exp. Med. 209, 741-759 (2012
41. Raab M., et al. T cell receptor inside-out pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity 32, 541-556 (2010
42. Sasai M., & Yamamoto M. Pathogen recognition receptors: ligands and signaling pathways by Toll-like receptors. Int. Rev. Immunol. 32, 116-133 (2013
43. Kawai T., & Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34, 637-650 (2011
44. Jiang X., & Chen Z.J. The role of ubiquitylation in immune defence and pathogen evasion. Nat. Rev. Immunol. 12, 35-48 (2012
45. Jiao S., et al. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nat. Immunol. 16, 246-257 (2015
46. Lehtinen M.K., et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987-1001 (2006
47. Yuan Z., et al. Regulation of neuronal cell death by MST1-FOXO1 signaling. J. Biol. Chem. 284, 11285-11292 (2009
48. Xiao L., et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J. Neurosci. 31, 9611-9619 (2011
49. Praskova M., Xia F., & Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr. Biol. 18, 311-321 (2008
50. Torrino S., et al. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev. Cell 21, 959-965 (2011