Humanized mice exhibit increased susceptibility to staphylococcus aureus pneumonia

Journal of Infectious Diseases

Volumn 215, Issue 9, 2017, Pages 1386-1395

  Prince, Alice ^a,b   Wang, Hui ^b   Kitur, Kipyegon ^b   Parker, Dane ^a  

^a Columbia University ^*  (United States)

^b Department of Medicine   (United States)

Author keywords

host pathogen; humanized; lung; mouse model; Panton Valentine leukocidin; pneumonia; PVL; respiratory; Staphylococcus aureus

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; COMPLEMENT COMPONENT C5A RECEPTOR; CRYOPYRIN; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 20; INTERLEUKIN 22; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PANTON VALENTINE LEUKOCIDIN; TUMOR NECROSIS FACTOR; BACTERIAL TOXIN; CYTOKINE; EXOTOXIN; LEUKOCIDIN; PANTON-VALENTINE LEUKOCIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL LOAD; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BLOOD; BONE MARROW CELL; BRONCHOALVEOLAR LAVAGE FLUID; CD3+ T LYMPHOCYTE; CD34 SELECTION; CELL DEATH; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE PREDISPOSITION; DISEASE SEVERITY; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LEUKOCYTE; LUKAB GENE; LUNG; LUNG INFECTION; MACROPHAGE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORBIDITY; MORTALITY; MOUSE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS AUREUS; ANIMAL; DISEASE MODEL; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; NONOBESE DIABETIC MOUSE; PATHOGENICITY; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL TOXINS; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; EXOTOXINS; HOST-PATHOGEN INTERACTIONS; HUMANS; LEUKOCIDINS; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PNEUMONIA, STAPHYLOCOCCAL; STAPHYLOCOCCUS AUREUS;

EID: 85021989813     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw425     Document Type: Article

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