Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Nature Chemical Biology

Volumn 14, Issue 3, 2018, Pages 311-316

  Yin, Hao ^a   Song, Chun Qing ^b   Suresh, Sneha ^a   Kwan, Suet Yan ^b   Wu, Qiongqiong ^a   Walsh, Stephen ^a   Ding, Junmei ^a   Bogorad, Roman L ^a   Zhu, Lihua Julie ^b   Wolfe, Scot A ^b   Koteliansky, Victor ^c   Xue, Wen ^b   Langer, Robert ^a,d,e   Anderson, Daniel G ^a,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEOTIDE; RNA; GREEN FLUORESCENT PROTEIN; GUIDE RNA; OLIGONUCLEOTIDE;

ARTICLE; CHIMERA; CRISPR-CAS9 SYSTEM; FEMALE; GENE EDITING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ALLELE; CELL SEPARATION; CHEMISTRY; CRISPR CAS SYSTEM; FLOW CYTOMETRY; GENETICS; HEK293 CELL LINE; JURKAT CELL LINE; TUMOR CELL LINE;

ALLELES; CELL LINE, TUMOR; CELL SEPARATION; CRISPR-CAS SYSTEMS; DNA; FLOW CYTOMETRY; GENE EDITING; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; JURKAT CELLS; NUCLEOTIDES; OLIGONUCLEOTIDES; RNA, GUIDE;

EID: 85042109500     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2559     Document Type: Article

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