Remote C-H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs

Journal of the American Chemical Society

Volumn 140, Issue 3, 2018, Pages 1165-1169

  Zwick, Christian R ^a   Renata, Hans ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; EFFICIENCY; ENZYMES; HYDROXYLATION; IRON COMPOUNDS;

ALIPHATIC AMINO ACIDS; AMINO ACID DERIVATIVES; C-H FUNCTIONALIZATION; CATALYTIC EFFICIENCIES; CHEMO-ENZYMATIC SYNTHESIS; CONCISE SYNTHESIS; FUTURE APPLICATIONS; ORGANIC SYNTHESIS;

SYNTHESIS (CHEMICAL);

2 OXOGLUTARIC ACID; ALIPHATIC AMINO ACID; ALKALOID DERIVATIVE; AMINO ACID; AMINO ACID DERIVATIVE; CARBON; DIOXYGENASE; HYDROGEN; MANZACIDIN C; PROLINE DERIVATIVE; UNCLASSIFIED DRUG; ALKB PROTEIN; PROLINE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BIOCATALYST; BIOTRANSFORMATION; CARBON HYDROGEN HYDROXYLATION; CHEMOENZYMATIC SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROXYLATION; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; MOLECULAR MODEL; STREPTOMYCES; SYNTHESIS;

ALKB ENZYMES; BIOCATALYSIS; ESCHERICHIA COLI; HYDROXYLATION; KETOGLUTARIC ACIDS; MODELS, MOLECULAR; PROLINE; PYRIMIDINES; PYRROLES; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 85041205932     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b12918     Document Type: Article

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