Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Journal of the American Chemical Society

Volumn 139, Issue 15, 2017, Pages 5317-5320

  Sato, Michio ^a,b   Dander, Jacob E ^a   Sato, Chizuru ^a   Hung, Yiu Sun ^a   Gao, Shu Shan ^a   Tang, Man Cheng ^a   Hang, Leibniz ^a   Winter, Jaclyn M ^a,c   Garg, Neil K ^a   Watanabe, Kenji ^b   Tang, Yi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; OLEFINS; SCAFFOLDS;

ADENYLATION DOMAINS; FREE AMINO ACIDS; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; POLYKETIDE SYNTHASES; STRUCTURAL DIVERSITY; SUCCINIMIDE; UNNATURAL AMINO ACIDS;

KETONES;

FUNGAL POLYKETIDE SYNTHASE; MALEIMIDE DERIVATIVE; NATURAL PRODUCT; NONRIBOSOMAL PEPTIDE SYNTHETASE; OXALEIMIDE A; OXALEIMIDE B; OXALEIMIDE C; POLYKETIDE SYNTHASE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; MALEIMIDE; SUCCINIMIDE;

ADENYLATION; ARTICLE; CELL VIABILITY ASSAY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HELA CELL LINE; IC50; KNOEVENAGEL CONDENSATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NONHUMAN; PENICILLIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOCHEMISTRY; CHEMISTRY; CONFORMATION; ENZYMOLOGY; METABOLISM;

BIOLOGICAL PRODUCTS; MALEIMIDES; MOLECULAR CONFORMATION; PENICILLIUM; POLYKETIDE SYNTHASES; SUCCINIMIDES;

EID: 85018504230     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b02432     Document Type: Article

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