Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents

Journal of the American Chemical Society

Volumn 139, Issue 44, 2017, Pages 15868-15877

  Nicolaou, K C ^a   Pulukuri, Kiran Kumar ^a   Rigol, Stephan ^a   Buchman, Marek ^a   Shah, Akshay A ^a   Cen, Nicholas ^a   McCurry, Megan D ^a   Beabout, Kathryn ^a   Shamoo, Yousif ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; ENANTIOSELECTIVITY;

BACTERIAL STRAINS; BIOLOGICAL EVALUATION; ENANTIOSELECTIVE TOTAL SYNTHESIS; IODOLACTONIZATION; KINETIC RESOLUTION; NATURAL PRODUCTS; STRUCTURE ACTIVITY RELATIONSHIPS; SYNTHETIC TECHNOLOGY;

SYNTHESIS (CHEMICAL);

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CJ 16264; CJ 16264 DERIVATIVE; MINOCYCLINE; TIGECYCLINE; UNCLASSIFIED DRUG; CJ-16,264; LACTONE; PYRAZOLE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMERIC RATIO; ENANTIOSELECTIVITY; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STEREOSELECTIVITY; CHEMISTRY; DRUG EFFECTS; GRAM POSITIVE BACTERIUM; GRAM POSITIVE INFECTION; HUMAN; MICROBIAL SENSITIVITY TEST; PROCEDURES; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; LACTONES; MICROBIAL SENSITIVITY TESTS; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85033232991     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b08749     Document Type: Article

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