Enzymatic C−H Oxidation–Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity

Angewandte Chemie - International Edition

Volumn 56, Issue 40, 2017, Pages 12234-12239

  Li, Jie ^a   Tang, Xiaoyu ^a   Awakawa, Takayoshi ^a,b   Moore, Bradley S ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

amidotransferase; cytochrome P450; potentiated bioactivity; selective C H activation; unnatural thiotetronates

Indexed keywords

AMIDES; ANTIBIOTICS; BIOSYNTHESIS; CHEMICAL ACTIVATION; ENZYMES; OXIDATION;

AMIDOTRANSFERASE; BIOSYNTHETIC ENZYMES; CASCADE REACTIONS; CYTOCHROME P450; SELECTIVE ACTIVATION; SELECTIVE FORMATION; SYNTHETIC METHODS; UNNATURAL THIOTETRONATES;

BIOACTIVITY;

AMIDE; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT; CYTOCHROME P450; THIOPHENE DERIVATIVE; THIOTETROMYCIN; TRANSFERASE;

BACTERIAL GENE; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; GENETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

AMIDES; ANTI-BACTERIAL AGENTS; BIOLOGICAL PRODUCTS; CATALYSIS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GENES, BACTERIAL; MASS SPECTROMETRY; OXIDATION-REDUCTION; PROTON MAGNETIC RESONANCE SPECTROSCOPY; STREPTOMYCES; THIOPHENES; TRANSFERASES;

EID: 85028624065     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201705239     Document Type: Article

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