The P450-4 Gene of Gibberella fujikuroi Encodes ent-Kaurene Oxidase in the Gibberellin Biosynthesis Pathway

Applied and Environmental Microbiology

Volumn 67, Issue 8, 2001, Pages 3514-3522

  Tudzynski, Bettina ^a   Hedden, Peter ^b   Carrera, Esther ^b   Gaskin, Paul ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENT KAURENE OXIDASE; ENT-KAURENE OXIDASE; GIBBERELLIN; OXYGENASE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; DNA SEQUENCE; ENZYMOLOGY; GENETICS; GIBBERELLA; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MUTATION; SEQUENCE ALIGNMENT; ULTRAVIOLET RADIATION;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; CULTURE MEDIA; CYTOCHROME P-450 ENZYME SYSTEM; GIBBERELLA; GIBBERELLINS; MOLECULAR SEQUENCE DATA; MUTATION; OXYGENASES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; ULTRAVIOLET RAYS;

EID: 0035430862     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.67.8.3514-3522.2001     Document Type: Article

References (36)

1. Ait-Ali, T., S. M. Swain, J. B. Reid, T.-P. Sun, and Y. Kamiya. 1997. The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A. Plant J. 11:443-454.
2. Barendse, G., W. M. P. H. van de Werken, and N. Takahashi. 1980. High-performance liquid chromatography of gibberellins. J. Chromatogr. 198:449-455.
3. Barrero, A. F., J. R. Oltra, E. Cabrera, F. Reyes, and M. Álvarez. 1999. Metabolism of gibberellins and ent-kaurenoids in mutants of Gibberella fujikuroi. Phytochemistry 50:1133-1140.
4. Bearder, J. R., J. MacMillan, M. Wels, M. B. Chaffey, and B. O. Phinney. 1974. Position of the metabolic block for gibberellin biosynthesis in mutant B1-41a of Gibberella fujikuroi. Phytochemistry 13:911-917.
5. Benito, E. P., A. ten Have, J. W. van't Klooster, and J. A. L. van Kan. 1998. Fungal and plant gene expression during synchronized infection of tomato leaves by Botrytis cinerea. Eur. J. Plant Pathol. 104:207-220.
6. Church, G. M., and W. Gilbert. 1984, Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
7. Desjardins, A. E., H. W. Gardner, and K.-M. Weltring. 1992. Detoxification of sesquiterpene phytoalexins by Gibberella pulicaris (Fusarium sambucinum) and its importance for virulence on potato tubers. J. Ind. Microbiol. 9:201-211.
8. Doyle, J. J., and J. L. Doyle. 1990. Isolation of plant DNA from fresh tissue. Focus 12:13-15.
9. Geissman, T. A., A. J. Verbiscar, B. O. Phinney, and G. Cragg. 1966. Studies on the biosynthesis of gibberellins from (-)-kaurenoic acid in cultures of Gibberella fujikuroi. Phytochemistry 5:933-947.
10. Graebe, J. E., P. Hedden, P. Gaskin, and J. MacMillan. 1974. Biosynthesis of gibberellins A12, A15, A24, A36 and A37 in a cell-free system from Cucurbita maxima. Phytochemistry 13:1433-1440.
11. Hedden, P. 1999. Recent advances in gibberellin biosynthesis. J. Exp. Bot. 50:553-563.
12. Hedden, P., and Y. Kamiya. 1997. Gibberellin biosynthesis: enzymes, genes and their regulation. Annu. Rev. Plant Physiol. Plant Mol. Biol. 48:431-460.
13. Helliwell, C. A., P. M. Chandler, A. Poole, E. S. Dennis, and W. J. Peacock. 2001. The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. Proc. Natl. Acad. Sci. USA 98:2065-2070.
14. Helliwell, C. A., A. Poole, W. J. Peacock, and E. S. Dennis. 1999. Arabidopsis ent-kaurene oxidase catalyzes three steps of gibberellin biosynthesis. Plant Physiol. 119:5117-510.
15. 3. Proc. Natl. Acad. Sci. USA 95:9019-9029.
16. Homann, V., K. Mende, C. Arntz, V. Hardi, G. Macino, G. Morelli, G. Böse, and B. Tudzynski. 1996. The isoprenoid pathway: cloning and characterization of fungal FPPS genes. Curr. Genet. 30:232-239.
17. Kawaide, H., R. T. Imai, R. Sassa, and Y. Kamiya. 1997. ent-Kaurene synthase from the fungus Phaeosphaeria sp. L487. J. Biol. Chem. 272:21706-21712.
18. Linnemannstöns, P., T. Voß, P. Hedden, P. Gaskin, and B. Tudzynski. 1999. Deletions in the gibberellin biosynthesis gene cluster of Gibberella fujikuroi hy REMI and conventional transformation-mediated mutagenesis. Appl. Environ. Microbiol. 65:2558-2564.
19. MacMillan J., D. A. Ward, A. L. Phillips, M. J. Sanchez-Beltran, P. Gaskin, T. Lange, and P. Hedden. 1997. Studies on the biosynthesis of gibberellins from (-)-kaurenoic acid in cultures of Gibberella fujikuroi. Plant Physiol. 113:1369-1377.
20. MacMillan, J. 1997. Biosynthesis of the gibberellin plant hormones. Nat. Prod. Res. 14:221-243.
21. Maniatis, T., J. Sambrook, and E. F. Fritsch. 1989. Molecular cloning, a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
22. Mende, K., V. Homann, and B. Tudzynski. 1997. The geranylgeranyl diphosphate synthase gene of Gibberella fujikuroi: isolation and expression. Mol. Gen. Genet. 255:96-105.
23. Neben, D. W., and D. R. Nelson. 1991. P450 gene nomenclature based on evolution. Methods Enzymol. 206:3-11.
24. Pontecorvo, G. V., J. A. Roper, L. M. Hemmonns, L. M., K. D. Mac Donald, and A. W. J. Buften. 1952. The genetics of Aspergillus nidulans. Adv. Genet. 5:141-238.
25. Punt, P. J., R. P. Oliver, M. A. Dingemanse, P. H. Pouwels, and C. A. M. J. J. van den Hondel. 1987. Transformation of Aspergillus nidulans based on the hygromycin B resistance marker from Escherichia coli. Gene 56:117-124.
26. Rademacher, W. 1997. Gibberellins, p. 193-205. In T. Anke (ed.), Fungal biotechnology. Chapman and Hall, London, United Kingdom.
27. Rojas, M. C., P. Hedden, P. Gaskin, and B. Tudzynski. 2001. The P450-1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis. Proc. Natl. Acad. Sci. USA 98:5828-5834.
28. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
29. Swain, S. M., J. J. Ross, J. B. Reid, and Y. Kamiya. 1995. Gibberellins and pea seed development. Expression of the Ih, IS and Ie mutations. Planta 195:426-433.
30. Tudzynski, B. 1997. Fungal phytohormones in pathogenic and mutualistic associations, p. 167-184. In G. C. Carroll and P. Tudzynski (ed.), Plant relationships. The Mycota V-1997. Springer-Verlag, Berlin, Germany.
31. Tudzynski, B., and K. Hölter. 1998. The gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster. Fungal Genet. Biol. 25:157-170.
32. Tudzynski, B., H. Kawaide, and Y. Kamiya. 1998. Gibberellin biosynthesis in Gibberella fitjikuroi; cloning and characterization of the copalyl diphosphate synthase gene. Curr. Genet. 34:234-240.
33. Tudzynski, B., K. Mende, K.-M. Wellring, S. E. Unkles, and J. R. Kinghorn. 1996. The Gibberella fujikuroi niaD gene encoding nitrate reductase: isolation, sequence, homologous transformation and electrophoretic karyotype location. Microbiology 142:533-539.
34. 14 synthesis in Gibberella fujikuroi. Phytochemistry 56:505-511.
35. 4 gene. Plant Physiol. 117:559-563.
36. Woitek, S., S. E. Unkles, J. R. Kinghorn, and B. Tudzynski. 1997 3-Hydroxy3-methylglutaryl-CoA reductase gene of Gibberella fujikuroi: isolation and characterization. Curr. Genet. 31:38-47.