Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity

Metabolism: Clinical and Experimental

Volumn 82, Issue , 2018, Pages 14-21

  van Niekerk, Gustav ^a   du Toit, André ^a   Loos, Ben ^a   Engelbrecht, Anna Mart ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Autophagy; Metabolic endotoxemia; Metabolic syndrome; Obesity; Paleolithic diet

Indexed keywords

INFLAMMASOME; PROTEIN AGGREGATE;

ADIPOSE TISSUE; AUTOPHAGY; DIET RESTRICTION; HOMEOSTASIS; HUMAN; LIVER; METABOLIC DISORDER; MITOCHONDRION; MUSCLE; NONHUMAN; NUTRIENT; OBESITY; PRIORITY JOURNAL; REVIEW; ANIMAL; CALORIC RESTRICTION; ENERGY METABOLISM; METABOLIC SYNDROME X; METABOLISM; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CALORIC RESTRICTION; ENERGY METABOLISM; HUMANS; METABOLIC DISEASES; METABOLIC SYNDROME; MITOCHONDRIA; OBESITY;

EID: 85041396039     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2017.12.007     Document Type: Review

References (64)

1. Katz, D., Meller, S., Can we say what diet is best for health?. Annu Rev Public Health 35 (2014), 83–103.
2. Sherman, P.W., Hash, G.A., Why vegetable recipes are not very spicy. Evol Hum Behav 22 (2001), 147–163.
3. Faurby, S., Svenning, J., Historic and prehistoric human-driven extinctions have reshaped global mammal diversity patterns. Divers Distrib 21 (2015), 1155–1166.
4. Weyrich, L.S., Duchene, S., Soubrier, J., Arriola, L., Llamas, B., Breen, J., et al. Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus. Nature 544 (2017), 357–361.
5. Turner, B.L., Thompson, A.L., Beyond the Paleolithic prescription: incorporating diversity and flexibility in the study of human diet evolution. Nutr Rev 71 (2013), 501–510.
6. Preissner, S.C., Hoffmann, M.F., Preissner, R., Dunkel, M., Gewiess, A., Preissner, S., Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy. PLoS One, 8, 2013, e82562.
7. Ingelman-Sundberg, M., Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J, 5, 2005, 6.
8. Lankisch, P., Lembcke, B., Wemken, G., Creutzfeldt, W., Functional reserve capacity of the exocrine pancreas. Digestion 35 (1986), 175–181.
9. DiMagno, E.P., Go, V.L., Summerskill, W., Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 288 (1973), 813–815.
10. DiMagno, E.P., Malagelada, J.R., Go, V.L., Relationship between alcoholism and pancreatic insufficiency. Ann N Y Acad Sci 252 (1975), 200–207.
11. Struyvenberg, M.R., Martin, C.R., Freedman, S.D., Practical guide to exocrine pancreatic insufficiency–breaking the myths. BMC Med, 15, 2017, 29.
12. Berbesque, J.C., Marlowe, F.W., Shaw, P., Thompson, P., Hunter-gatherers have less famine than agriculturalists. Biol Lett, 10, 2014, 20130853, 10.1098/rsbl.2013.0853.
13. Mattson, M.P., Allison, D.B., Fontana, L., Harvieg, M., Longoh, V.D., Malaissei, W.J., et al. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A 111 (2014), 16647–16653, 10.1073/pnas.1413965111.
14. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., et al. The role of autophagy during the early neonatal starvation period. Nature 432 (2004), 1032–1036.
15. Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136 (2009), 521–534.
16. Dagon, Y., Mantzoros, C., Kim, Y.B., Exercising insulin sensitivity: AMPK turns on autophagy!. Metabolism 64 (2015), 655–657, 10.1016/j.metabol.2015.03.002.
17. Loos, B., Engelbrecht, A.M., Lockshin, R.A., Klionsky, D.J., Zakeri, Z., The variability of autophagy and cell death susceptibility: unanswered questions. Autophagy 9 (2013), 1270–1285, 10.4161/auto.25560.
18. Liu, H.Y., Han, J., Cao, S.Y., Hong, T., Zhuo, D., Shi, J., et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 284 (2009), 31484–31492, 10.1074/jbc.M109.033936.
19. Loos, B., Klionsky, D.J., Wong, E., Augmenting brain metabolism to increase macro-and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging. Prog Neurobiol 156 (2017), 90–106.
20. Lee, J.M., Wagner, M., Xiao, R., Kim, K.H., Feng, D., Lazar, M.A., et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 516:7529 (2014), 112–115.
21. He, C., Sumpter, J., Rhea, Levine, B., Exercise induces autophagy in peripheral tissues and in the brain. Autophagy 8 (2012), 1548–1551.
22. Soussi, H., Reggio, S., Alili, R., Prado, C., Mutel, S., Pini, M., et al. DAPK2 downregulation associates with attenuated adipocyte autophagic clearance in human obesity. Diabetes 64 (2015), 3452–3463, 10.2337/db14-1933.
23. Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R.L., Ferrante, A.W. Jr., Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003), 1796–1808, 10.1172/JCI19246.
24. Nguyen, M.T., Favelyukis, S., Nguyen, A.K., Reichart, D., Scott, P.A., Jenn, A., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 282 (2007), 35279–35292 [DOI M706762200, pii].
25. Yoshizaki, T., Kusunoki, C., Kondo, M., Yasuda, M., Kume, S., Morino, K., et al. Autophagy regulates inflammation in adipocytes. Biochem Biophys Res Commun 417 (2012), 352–357.
26. Huang, J., Brumell, J.H., Bacteria-autophagy interplay: a battle for survival. Nat Rev Microbiol, 12, 2014, 101.
27. Yang, L., Li, P., Fu, S., Calay, E.S., Hotamisligil, G.S., Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 11 (2010), 467–478.
28. Kramer, C.K., Zinman, B., Retnakaran, R., Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 1 (2013), 28–34.
29. Rosa-Caldwell, M.E., Lee, D.E., Brown, J.L., Brown, L.A., Perry, R.A. Jr., Greene, E.S., et al. Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. Appl Physiol Nutr Metab 42 (2016), 148–156.
30. Kim, K.H., Jeong, Y.T., Oh, H., Kim, S.H., Cho, J.M., Kim, Y., et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 19 (2013), 83–92.
31. He, C., Bassik, M.C., Moresi, V., Sun, K., Wei, Y., Zou, Z., et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481 (2012), 511–515, 10.1038/nature10758.
32. Liu, X., Niu, Y., Yuan, H., Huang, J., Fu, L., AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy. Metab Clin Exp 64 (2015), 658–665.
33. Yamahara, K., Kume, S., Koya, D., Tanaka, Y., Morita, Y., Chin-Kanasaki, M., et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol 24 (2013), 1769–1781, 10.1681/ASN.2012111080.
34. Li, Z.L., Woollard, J.R., Ebrahimi, B., Crane, J.A., Jordan, K.L., Lerman, A., et al. Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol 32 (2012), 1132–1141, 10.1161/ATVBAHA.111.244061.
35. Razay, G., Vreugdenhil, A., Wilcock, G., The metabolic syndrome and Alzheimer disease. Arch Neurol 64 (2007), 93–96.
36. Procaccini, C., Santopaolo, M., Faicchia, D., Colamatteo, A., Formisano, L., de Candia, P., et al. Role of metabolism in neurodegenerative disorders. Metab Clin Exp 65 (2016), 1376–1390.
37. Boland, B., Kumar, A., Lee, S., Platt, F.M., Wegiel, J., Yu, W.H., et al. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28 (2008), 6926–6937, 10.1523/JNEUROSCI.0800-08.2008.
38. Ryter, S.W., Koo, J.K., Choi, A.M., Molecular regulation of autophagy and its implications for metabolic diseases. Curr Opin Clin Nutr Metab Care 17 (2014), 329–337, 10.1097/MCO.0000000000000068.
39. Youle, R.J., van der Bliek, A.M., Mitochondrial fission, fusion, and stress. Science 337 (2012), 1062–1065, 10.1126/science.1219855.
40. Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., et al. ER stress (PERK/eIF2 [alpha] phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ, 14, 2007, 230.
41. Schuck, S., Gallagher, C.M., Walter, P., ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci 127 (2014), 4078–4088, 10.1242/jcs.154716.
42. Khaminets, A., Heinrich, T., Mari, M., Grumati, P., Huebner, A.K., Akutsu, M., et al. Regulation of endoplasmic reticulum turnover by selective autophagy. Nature, 522, 2015, 354.
43. Zhang, K., Kaufman, R.J., From endoplasmic-reticulum stress to the inflammatory response. Nature 454 (2008), 455–462, 10.1038/nature07203.
44. Guo, H., Callaway, J.B., Ting, J.P., Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21 (2015), 677–687, 10.1038/nm.3893.
45. Shi, C., Shenderov, K., Huang, N., Kabat, J., Abu-Asab, M., Fitzgerald, K.A., et al. Activation of autophagy by inflammatory signals limits IL-1 [beta] production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 13 (2012), 255–263.
46. Yuk, J., Jo, E., Crosstalk between autophagy and inflammasomes. Mol Cells 36 (2013), 393–399.
47. Pendyala, S., Walker, J.M., Holt, P.R., A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142 (2012), 1100. e2–1101. e2.
48. Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., Eckhardt, E., Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res 50 (2009), 90–97, 10.1194/jlr.M800156-JLR200.
49. Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C., Lambert-Porcheron, S., et al. Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem 22 (2011), 53–59.
50. Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (2007), 1761–1772 [DOI db06-1491].
51. Zhang, D., Zhou, J., Ye, L.C., Li, J., Wu, Z., Li, Y., et al. Autophagy maintains the integrity of endothelial barrier in LPS-induced lung injury. J Cell Physiol 233:1 (2017), 688–698.
52. Guo, L., Zheng, Z., Ai, J., Huang, B., Li, X.A., Hepatic scavenger receptor BI protects against polymicrobial-induced sepsis through promoting LPS clearance in mice. J Biol Chem 289 (2014), 14666–14673, 10.1074/jbc.M113.537258.
53. Mathison, J.C., Ulevitch, R.J., The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol 123 (1979), 2133–2143.
54. Shao, B., Lu, M., Katz, S.C., Varley, A.W., Hardwick, J., Rogers, T.E., et al. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 282 (2007), 13726–13735 [DOI M609462200, pii].
55. McDermott, C., Fenwick, B., Neutrophil activation associated with increased neutrophil acyloxyacyl hydrolase activity during inflammation in cattle. Am J Vet Res 53 (1992), 803–807.
56. Bravo-San Pedro, J.M., Kroemer, G., Galluzzi, L., Autophagy and mitophagy in cardiovascular disease. Circ Res 120 (2017), 1812–1824, 10.1161/CIRCRESAHA.117.311082.
57. Mattson, M.P., Longo, V.D., Harvie, M., Impact of intermittent fasting on health and disease processes. Ageing Res Rev 39 (2017), 46–58.
58. Wu, J., Wu, J., Yang, L., Wei, L., Zou, D., Rosiglitazone protects against palmitate-induced pancreatic beta-cell death by activation of autophagy via 5′-AMP-activated protein kinase modulation. Endocrine 44 (2013), 87–98.
59. Cerquetti, L., Sampaoli, C., Amendola, D., Bucci, B., Masuelli, L., Marchese, R., et al. Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells. Exp Cell Res 317 (2011), 1397–1410.
60. Xie, Z., Lau, K., Eby, B., Lozano, P., He, C., Pennington, B., et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 60 (2011), 1770–1778, 10.2337/db10-0351.
61. Al-Attas, O.S., Al-Daghri, N.M., Al-Rubeaan, K., da Silva, N.F., Sabico, S.L., Kumar, S., et al. Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies. Cardiovasc Diabetol, 8, 2009, 20.
62. Münz, C., Autophagy proteins in antigen processing for presentation on MHC molecules. Immunol Rev 272 (2016), 17–27.
63. English, L., Chemali, M., Duron, J., Rondeau, C., Laplante, A., Gingras, D., et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 10 (2009), 480–487.
64. van Niekerk, G., Loos, B., Nell, T., Engelbrecht, A., Autophagy—a free meal in sickness-associated anorexia. Autophagy 12 (2016), 727–734, 10.1080/15548627.2016.1147672.