Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Cell

Volumn 172, Issue 1-2, 2018, Pages 135-146.e9

  Bekkering, Siroon ^a,b   Arts, Rob J W ^a   Novakovic, Boris ^c   Kourtzelis, Ioannis ^d   van der Heijden, Charlotte D C C ^a   Li, Yang ^g   Popa, Calin D ^a   ter Horst, Rob ^a   van Tuijl, Julia ^a   Netea Maier, Romana T ^c   van de Veerdonk, Frank L ^a   Chavakis, Triantafyllos ^d   Joosten, Leo A B ^a,e   van der Meer, Jos W M ^a   Stunnenberg, Henk ^c   Riksen, Niels P ^a   Netea, Mihai G ^a,f  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^f UNIVERSITY OF BONN   (Germany)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

epigenetics; HIDS; hyper IgD syndrome; immunometabolism; innate immune memory; macrophages; metabolism; mevalonate kinase deficiency; monocytes; trained immunity

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONATE KINASE; MEVALONIC ACID; SOMATOMEDIN C RECEPTOR;

ARTICLE; BONE MARROW CELL; CHOLESTEROL SYNTHESIS; CYTOKINE PRODUCTION; EPIGENETICS; HISTONE MODIFICATION; HUMAN; HYPERIMMUNOGLOBULINEMIA D AND PERIODIC FEVER SYNDROME; IMMUNITY; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; METABOLISM; MONOCYTE; NONHUMAN; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALE; MEVALONATE KINASE DEFICIENCY; MOUSE;

ANIMALS; CELLS, CULTURED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; MALE; MEVALONATE KINASE DEFICIENCY; MEVALONIC ACID; MICE; MICE, INBRED C57BL; MONOCYTES; RECEPTOR, IGF TYPE 1;

EID: 85041099399     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.11.025     Document Type: Article

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