Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

PLoS Pathogens

Volumn 10, Issue 10, 2014, Pages

  Buffen, Kathrin ^a,b   Oosting, Marije ^a,b   Quintin, Jessica ^a,b   Ng, Aylwin ^c,d   Kleinnijenhuis, Johanneke ^a,b   Kumar, Vinod ^e   van de Vosse, Esther ^f   Wijmenga, Cisca ^e   van Crevel, Reinout ^a,b   Oosterwijk, Egbert ^a   Grotenhuis, Anne J ^a   Vermeulen, Sita H ^a   Kiemeney, Lambertus A ^a   van de Veerdonk, Frank L ^a,b   Chamilos, Georgios ^g   Xavier, Ramnik J ^c,d   van der Meer, Jos W M ^a,b   Netea, Mihai G ^a,b   Joosten, Leo A B ^a,b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCAN; GENOMIC DNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; ATG2B PROTEIN, HUMAN; ATG5 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN; AUTOPHAGY RELATED PROTEIN 5; BCG VACCINE; CYTOKINE; IMMUNOLOGICAL ADJUVANT; MICROTUBULE ASSOCIATED PROTEIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; AUTOPHAGY; BCG VACCINATION; BLADDER CANCER; CANCER GROWTH; CANCER RECURRENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EPIGENETIC REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOFLUORESCENCE TEST; MONOCYTE CULTURE; PATHOGENESIS; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TRAINED IMMUNITY; GENETICS; IMMUNOLOGY; INTRAVESICAL DRUG ADMINISTRATION; KAPLAN MEIER METHOD; METABOLISM; MONOCYTE; MYCOBACTERIUM BOVIS; TUMOR RECURRENCE; URINARY BLADDER NEOPLASMS; VACCINATION; VIROLOGY;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRAVESICAL; ANTINEOPLASTIC AGENTS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEINS; BCG VACCINE; BETA-GLUCANS; CYTOKINES; HUMANS; KAPLAN-MEIER ESTIMATE; MICROTUBULE-ASSOCIATED PROTEINS; MONOCYTES; MYCOBACTERIUM BOVIS; NEOPLASM RECURRENCE, LOCAL; POLYMORPHISM, SINGLE NUCLEOTIDE; URINARY BLADDER NEOPLASMS; VACCINATION; VESICULAR TRANSPORT PROTEINS;

EID: 84908347960     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004485     Document Type: Article

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