Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Cell

Volumn 172, Issue 1-2, 2018, Pages 162-175.e14

  Christ, Anette ^a,b   Günther, Patrick ^c   Lauterbach, Mario A R ^a   Duewell, Peter ^d   Biswas, Debjani ^b   Pelka, Karin ^e   Scholz, Claus J ^c   Oosting, Marije ^f   Haendler, Kristian ^c   Baßler, Kevin ^c   Klee, Kathrin ^c   Schulte Schrepping, Jonas ^c   Ulas, Thomas ^c   Moorlag, Simone J C F M ^f   Kumar, Vinod ^g   Park, Min Hi ^h,i   Joosten, Leo A B ^f   Groh, Laszlo A ^f   Riksen, Niels P ^f   Espevik, Terje ^j   Schlitzer, Andreas ^c   Li, Yang ^g   Fitzgerald, Michael L ^h   Netea, Mihai G ^c,f   Schultze, Joachim L ^c,k   Latz, Eicke ^a,b,j,k   more..

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ TEXAS A AND M UNIVERSITY   (United States)

^j NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^k GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

more..

Author keywords

ASC; atherosclerosis; epigenetic reprogramming; granulocyte macrophage progenitors; innate immune memory; NLRP3 inflammasome; non communicable diseases; sterile inflammation; trained immunity; Western diet feeding

Indexed keywords

CRYOPYRIN; INTERFERON; LIPOPOLYSACCHARIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; NLRP3 PROTEIN, MOUSE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REPROGRAMMING TECHNIQUE; CONTROLLED STUDY; EPIGENETICS; FEMALE; GENE ONTOLOGY; HUMAN; HUMAN CELL; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; UPREGULATION; WESTERN DIET; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NUCLEAR REPROGRAMMING;

ADULT; AGED; ANIMALS; CELLS, CULTURED; CELLULAR REPROGRAMMING; DIET, WESTERN; EPIGENESIS, GENETIC; FEMALE; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; LIPOPROTEINS, LDL; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MYELOID CELLS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; QUANTITATIVE TRAIT LOCI; RECEPTORS, LDL;

EID: 85041124000     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.12.013     Document Type: Article

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