Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 8, 2014, Pages 1731-1738

  Bekkering, Siroon ^a   Quintin, Jessica ^a   Joosten, Leo A B ^a   Van Der Meer, Jos W M ^a   Netea, Mihai G ^a   Riksen, Niels P ^b  

^a Division of Vascular Medicine   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Atherosclerosis; Epigenomics; Inflammation; Monocytes; Oxidized low density lipoprotein

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; BETA GLUCAN; CD36 ANTIGEN; GELATINASE A; GELATINASE B; HISTONE H4; INTERLEUKIN 18; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATHEROSCLEROSIS; CHROMATIN IMMUNOPRECIPITATION; CYTOKINE PRODUCTION; DOWN REGULATION; EPIGENETICS; FOAM CELL; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MACROPHAGE ACTIVATION; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ATHEROSCLEROSIS; EPIGENOMICS; INFLAMMATION; MONOCYTES; OXIDIZED LOW-DENSITY LIPOPROTEIN;

ANTIGENS, CD36; ATHEROSCLEROSIS; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CYTOKINES; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FOAM CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; INFLAMMATION MEDIATORS; LIPOPROTEINS, LDL; MONOCYTES; NUCLEAR REPROGRAMMING; PHENOTYPE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS A; TIME FACTORS;

EID: 84904605889     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303887     Document Type: Article

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