Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Rozman, Jan ^a,b   Rathkolb, Birgit ^a,b,c   Oestereicher, Manuela A ^a   Schütt, Christine ^a   Ravindranath, Aakash Chavan ^a,b   Leuchtenberger, Stefanie ^a   Sharma, Sapna ^a,b   Kistler, Martin ^a   Willershäuser, Monja ^d,e   Brommage, Robert ^a   Meehan, Terrence F ^f   Mason, Jeremy ^f   Haselimashhadi, Hamed ^f   Aguilar Pimentel, Antonio ^a   Becker, Lore ^a   Treise, Irina ^a   Moreth, Kristin ^a   Garrett, Lillian ^a   Hölter, Sabine M ^a   Zimprich, Annemarie ^a   Marschall, Susan ^a   Amarie, Oana V ^a   Calzada Wack, Julia ^a   Neff, Frauke ^a   Brachthäuser, Laura ^a   Lengger, Christoph ^a   Stoeger, Claudia ^a   Zapf, Lilly ^a   Cho, Yi Li ^a   Da Silva Buttkus, Patricia ^a   Kraiger, Markus J ^a   Mayer Kuckuk, Philipp ^a   Gampe, Karen Kristine ^a   Wu, Moya ^a   Conte, Nathalie ^f   Warren, Jonathan ^f   Chen, Chao Kung ^f   Tudose, Ilinca ^f   Relac, Mike ^f   Matthews, Peter ^f   Cater, Heather L ^g   Natukunda, Helen P ^g   Cleak, James ^g   Teboul, Lydia M ^g   Clementson Mobbs, Sharon ^g   Szoke Kovacs, Zsombor ^g   Walling, Alison P ^g   Johnson, Sara J ^g   Codner, Gemma F ^g   Fiegel, Tanja ^g   Ring, Natalie ^g   Westerberg, Henrik ^g   Greenaway, Simon ^g   Sneddon, Duncan ^g   Morgan, Hugh ^g   Loeffler, Jorik ^g   Stewart, Michelle E ^g   Ramirez Solis, Ramiro ^h   Bradley, Allan ^h   Skarnes, William C ^h   Steel, Karen P ^h   Maguire, Simon A ^h   Dench, Joshua ^h   Lafont, David ^h   Vancollie, Valerie E ^h   Pearson, Selina A ^h   Gates, Amy S ^h   Sanderson, Mark ^h   Shannon, Carl ^h   Anthony, Lauren F E ^h   Sumowski, Maksymilian T ^h   McLaren, Robbie S B ^h   Doe, Brendan ^h   Wardle Jones, Hannah ^h   Griffiths, Mark N D ^h   Galli, Antonella ^h   Swiatkowska, Agnieszka ^h   Isherwood, Christopher M ^h   Speak, Anneliese O ^h   Cambridge, Emma L ^h   Wilson, Heather M ^h   Caetano, Susana S ^h   Maguire, Anna Karin B ^h   Adams, David J ^h   Bottomley, Joanna ^h   Ryder, Ed ^h   Gleeson, Diane ^h   Pouilly, Laurent ^j,k,l,m,n   Rousseau, Stephane ^j,k,l,m,n   Auburtin, Aurélie ^j,k,l,m,n   Reilly, Patrick ^j,k,l,m,n   Ayadi, Abdel ^j,k,l,m,n   Selloum, Mohammed ^j,k,l,m,n   Wood, Joshua A ^o   Clary, Dave ^o   Havel, Peter ^o   Tolentino, Todd ^o   Tolentino, Heather ^o   Schuchbauer, Mike ^o   Pedroia, Sheryl ^o   Trainor, Amanda ^o   Djan, Esi ^o   Pham, Milton ^o   Huynh, Alison ^o   De Vera, Vincent ^o   Seavitt, John ^p   Gallegos, Juan ^p   Garza, Arturo ^p   Mangin, Elise ^p   Senderstrom, Joel ^p   Lazo, Iride ^p   Mowrey, Kate ^p   Bohat, Ritu ^p   Samaco, Rodney ^p   Veeraragavan, Surabi ^p   Beeton, Christine ^p   Kalaga, Sowmya ^p   Kelsey, Lois ^q,r   Vukobradovic, Igor ^q,r   Berberovic, Zorana ^q,r   Owen, Celeste ^q,r   Qu, Dawei ^q,r   Guo, Ruolin ^q,r   Newbigging, Susan ^q,r   Morikawa, Lily ^q,r   Law, Napoleon ^q,r   Shang, Xueyuan ^q,r   Feugas, Patricia ^q,r   Wang, Yanchun ^q,r   Eskandarian, Mohammad ^q,r   Zhu, Yingchun ^q,r   Penton, Patricia ^q,r   Laurin, Valerie ^q,r   Clarke, Shannon ^q,r   Lan, Qing ^q,r   Sleep, Gillian ^q,r   Creighton, Amie ^q,r   Jacob, Elsa ^q,r   Danisment, Ozge ^q,r   Gertsenstein, Marina ^q,r   Pereira, Monica ^q,r   MacMaster, Suzanne ^q,r   Tondat, Sandra ^q,r   Carroll, Tracy ^q,r   Cabezas, Jorge ^q,r   Hunter, Jane ^q,r   Clark, Greg ^q,r   Bubshait, Mohammed ^q,r   Miller, David ^q,r   Sohel, Khondoker ^q,r   Adissu, Hibret ^q,r   Ganguly, Milan ^q,r   Bezginov, Alexandr ^q,r   Chiani, Francesco ^u   Di Pietro, Chiara ^u   Di Segni, Gianfranco ^u   Ermakova, Olga ^u   Ferrara, Filomena ^u   Fruscoloni, Paolo ^u   Gambadoro, Aalessia ^u   Gastaldi, Serena ^u   Golini, Elisabetta ^u   La Sala, Gina ^u   Mandillo, Silvia ^u   Marazziti, Daniela ^u   Massimi, Marzia ^u   Matteoni, Rafaele ^u   Orsini, Tiziana ^u   Pasquini, Miriam ^u   Raspa, Marcello ^u   Rauch, Aline ^u   Rossi, Gianfranco ^u   Rossi, Nicoletta ^u   Putti, Sabrina ^u   Scavizzi, Ferdinando ^u   Tocchini Valentini, Giuseppe D ^u   Wakana, Shigeharu ^z   Suzuki, Tomohiro ^z   Tamura, Masaru ^z   Kaneda, Hideki ^z   Furuse, Tamio ^z   Kobayashi, Kimio ^z   Miura, Ikuo ^z   Yamada, Ikuko ^z   Obata, Yuichi ^z   Yoshiki, Atsushi ^z   Ayabe, Shinya ^z   Chambers, J Nicole ^aa   Chalupsky, Karel ^aa   Seisenberger, Claudia ^a   Bürger, Antje ^a   Beig, Joachim ^a   Kühn, Ralf ^a,ah,ai   Hörlein, Andreas ^a   Schick, Joel ^a   Oritz, Oskar ^a   Giesert, Florian ^a   Graw, Jochen ^a   Ollert, Markus ^aj,ak   Schmidt Weber, Carsten ^d   Stoeger, Tobias ^a   Önder Yildirim, Ali ^a   Eickelberg, Oliver ^a   Klopstock, Thomas ^c,ae,al   Busch, Dirk H ^e   Bekeredjian, Raffi ^am   Zimmer, Andreas ^an   Jacobsen, Jules O ^ao   Smedley, Damian ^ao   Dickinson, Mary E ^p   Benso, Frank ^ap   Morse, Iva ^ap   Kim, Hyoung Chin ^aq   Lee, Ho ^ar   Cho, Soo Young ^ar   Hough, Tertius ^g   Mallon, Ann Marie ^g   Wells, Sara ^g   Santos, Luis ^g   Lelliott, Christopher J ^h   White, Jacqueline K ^h,i   Sorg, Tania ^j,k,l,m,n   Champy, Marie France ^j,k,l,m,n   Bower, Lynette R ^o   Reynolds, Corey L ^p   Flenniken, Ann M ^q,r,s   Murray, Stephen A ⁱ   Nutter, Lauryl M J ^q,r   Svenson, Karen L ⁱ   West, David ^t   Tocchini Valentini, Glauco P ^u   Beaudet, Arthur L ^q,r   Bosch, Fatima ^v   Braun, Robert B ⁱ   Dobbie, Michael S ^w   Gao, Xiang ^x   Herault, Yann ^j,k,l,m,n   Moshiri, Ala ^o   Moore, Bret A ^y   Kent Lloyd, K C ^o   McKerlie, Colin ^q,r   Masuya, Hiroshi ^z   Tanaka, Nobuhiko ^z   Flicek, Paul ^f   Parkinson, Helen E ^f   Sedlacek, Radislav ^aa   Seong, Je Kyung ^ab   Wang, Chi Kuang Leo ^ac   Moore, Mark ^ad   Brown, Steve D ^g   Tschöp, Matthias H ^a,b,d   Wurst, Wolfgang ^a,c,d,ae   Klingenspor, Martin ^d,e   Wolf, Eckhard ^b,c   Beckers, Johannes ^a,b,d   MacHicao, Fausto ^af   Peter, Andreas ^b,af   Staiger, Harald ^b,af   Häring, Hans Ulrich ^b,af   Grallert, Harald ^a,b,c   Campillos, Monica ^a,b   Maier, Holger ^a   Fuchs, Helmut ^a   Gailus Durner, Valerie ^a   Werner, Thomas ^ag   De Angelis, Martin Hrabe ^a,b,d   more..

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^g Medical Research Council Harwell Institute   (United Kingdom)

^h WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

ⁱ JACKSON LABORATORY   (United States)

^j INSTITUT CLINIQUE DE LA SOURIS   (France)

^k INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^l CNRS   (France)

^m INSERM   (France)

ⁿ UNIVERSITÉ DE STRASBOURG   (France)

^o UNIVERSITY OF CALIFORNIA   (United States)

^p BAYLOR COLLEGE OF MEDICINE   (United States)

^q Centre for Phenogenomics (TCP)   (Canada)

^r HOSPITAL FOR SICK CHILDREN   (Canada)

^s MOUNT SINAI HOSPITAL   (Canada)

^t CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^u CNR   (Italy)

^v UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^w Biology and Environment   (Australia)

^x NANJING UNIVERSITY   (China)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z RIKEN BIORESOURCE CENTER   (Japan)

^aa INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^ab Seoul National University   (South Korea)

^ac NATIONAL APPLIED RESEARCH LABORATORIES   (Taiwan)

^ad IMPC   (United States)

^ae GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^af UNIVERSITY OF TÜBINGEN   (Germany)

^ag UNIVERSITY OF MICHIGAN   (United States)

^ah MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^ai BERLIN INSTITUTE OF HEALTH   (Germany)

^aj LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^ak UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^al LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^am UNIVERSITY OF HEIDELBERG   (Germany)

^an UNIVERSITY OF BONN   (Germany)

^ao QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^ap CHARLES RIVER LABORATORIES   (United States)

^aq Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^ar National Cancer Center   (South Korea)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

COMPARATIVE STUDY; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; IDENTIFICATION METHOD; METABOLISM; PHENOTYPE; RODENT;

ARTICLE; BINDING SITE; BODY MASS; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENETIC IDENTIFICATION; GENOME-WIDE ASSOCIATION STUDY; HIGH THROUGHPUT SCREENING; HUMAN; KNOCKOUT GENE; KNOCKOUT MOUSE; LIBRARY SCIENCE; MALE; METABOLIC DISORDER; METABOLISM; MOLECULAR GENETICS; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; ANIMAL; AREA UNDER THE CURVE; BASAL METABOLIC RATE; BODY WEIGHT; GENE REGULATORY NETWORK; GENETICS; GLUCOSE BLOOD LEVEL; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXYGEN CONSUMPTION;

MAMMALIA;

ANIMALS; AREA UNDER CURVE; BASAL METABOLISM; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METABOLIC DISEASES; MICE; MICE, KNOCKOUT; OBESITY; OXYGEN CONSUMPTION; PHENOTYPE; TRIGLYCERIDES;

EID: 85040788526     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-01995-2     Document Type: Article

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