A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples

Molecular Psychiatry

Volumn 21, Issue 7, 2016, Pages 975-982

  Cohen, O S ^a   Weickert, T W ^b,c,d   Hess, J L ^a   Paish, L M ^a   McCoy, S Y ^a   Rothmond, D A ^c   Galletly, C ^e,f   Liu, D ^f   Weinberg, D D ^c   Huang, X F ^f,g   Xu, Q ^h   Shen, Y ^h   Zhang, D ⁱ   Yue, W ⁱ   Yan, J ⁱ   Wang, L ⁱ   Lu, T ⁱ   He, L ^j   Shi, Y ^j   Xu, M ^j   Che, R ^j   Tang, W ^j   Chen, C H ^k   Chang, W H ^k   Hwu, H G ^l,m   Liu, C M ^l   Liu, Y L ^l   Wen, C C ^l   Fann, C S J ⁿ   Chang, C C ⁿ   Kanazawa, T ^o   Middleton, F A ^p   Duncan, T M ^a   Faraone, S V ^a,p   Weickert, C S ^b,c,d   Tsuang, M T ^q,r,s   Glatt, S J ^a,p   more..

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^d Schizophrenia Research Institute   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f LYELL MCEWIN HOSPITAL   (Australia)

^g UNIVERSITY OF WOLLONGONG   (Australia)

^h INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

ⁱ PEKING UNIVERSITY SIXTH HOSPITAL   (China)

^j SHANGHAI JIAO TONG UNIVERSITY   (China)

^k NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^l NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^m NATIONAL TAIWAN UNIVERSITY   (Taiwan)

ⁿ INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^o OSAKA MEDICAL COLLEGE   (Japan)

^p SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^q UNIVERSITY OF CALIFORNIA   (United States)

^r HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^s VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; DNA; DOPAMINE 2 RECEPTOR; HALOPERIDOL; MESSENGER RNA PRECURSOR; OLANZAPINE; RNA ISOFORM; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER RAN BINDING DOMAIN CONTAINING 2; DRD2 PROTEIN, HUMAN; RNA BINDING PROTEIN; RNA PRECURSOR; ZRANB2 PROTEIN, HUMAN;

ADULT; ALLELE; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION RATE CONSTANT; AUTOPSY; BINDING AFFINITY; BINDING SITE; BRAIN WEIGHT; COGNITIVE DEFECT; COMPREHENSION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISSOCIATION; DNA POLYMORPHISM; DRUG EXPOSURE; EXON; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE FREQUENCY; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; GENOTYPE; HAN CHINESE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; LEARNING; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NONHUMAN; OBSERVED RATE CONSTANT; OLIGONUCLEOTIDE PROBE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PSYCHOPHARMACOTHERAPY; RAT; SCHIZOPHRENIA; TASK PERFORMANCE; VERBAL COMPREHENSION; VERBAL FLUENCY; WORKING MEMORY; BRAIN; CHINA; COGNITION; ETHNIC GROUP; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PHYSIOLOGY; RISK FACTOR; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; ALTERNATIVE SPLICING; BRAIN; CHINA; COGNITION; ETHNIC GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; RISK FACTORS; RNA PRECURSORS; RNA SPLICING; RNA-BINDING PROTEINS; SCHIZOPHRENIA;

EID: 84940934684     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.137     Document Type: Article

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