In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice

Nature Neuroscience

Volumn 21, Issue 3, 2018, Pages 440-446

  Zhou, Haibo ^a   Liu, Junlai ^b,c,d   Zhou, Changyang ^a,c   Gao, Ni ^a,c   Rao, Zhiping ^a,c   Li, He ^a,c   Hu, Xinde ^a,c   Li, Changlin ^a   Yao, Xuan ^a   Shen, Xiaowen ^a   Sun, Yidi ^e   Wei, Yu ^a   Liu, Fei ^a,c   Ying, Wenqin ^a   Zhang, Junming ^a   Tang, Cheng ^a,c   Zhang, Xu ^a   Xu, Huatai ^a   Shi, Linyu ^a   Cheng, Leping ^a   Huang, Pengyu ^b   Yang, Hui ^a   more..

^a Shenzhen Fundamental Research Institutions   (China)

^b SHANGHAITECH UNIVERSITY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; LONG UNTRANSLATED RNA; NERVE PROTEIN; NEUN PROTEIN, MOUSE; NUCLEAR PROTEIN;

ANIMAL CELL; ARTICLE; ASCL1 GENE; ASTROCYTE; BRAIN; CONTROLLED STUDY; EMBRYO; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; IN VIVO STUDY; MALE; MOUSE; NEUROD1 GENE; NEUROG2 GENE; NONHUMAN; PRIMARY CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; ANIMAL; BRAIN CHEMISTRY; CRISPR CAS SYSTEM; GENETICS; METABOLISM; NERVE CELL; NERVOUS SYSTEM; PHYSIOLOGY; PRIMARY CELL CULTURE; TRANSCRIPTION INITIATION;

ANIMALS; ASTROCYTES; BRAIN CHEMISTRY; CRISPR-CAS SYSTEMS; FEMALE; MALE; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; NEURONS; NUCLEAR PROTEINS; PRIMARY CELL CULTURE; RNA, LONG NONCODING; TRANSCRIPTIONAL ACTIVATION;

EID: 85040645307     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/s41593-017-0060-6     Document Type: Article

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