Dual role of Ski in pancreatic cancer cells: Tumor-promoting versus metastasis-suppressive function

Carcinogenesis

Volumn 30, Issue 9, 2009, Pages 1497-1506

  Wang, Peng ^a   Chen, Zhen ^a   Meng, Zhi Qiang ^a   Fan, Jie ^b   Luo, Jian Min ^a   Liang, Wang ^a   Lin, Jun Hua ^a   Zhou, Zhen Hua ^a   Chen, Hao ^a   Wang, Kun ^a   Shen, Ye Hua ^a   Xu, Zu De ^b   Liu, Lu Ming ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN SKI; SLOAN KETTERING VIRUS PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; SKI PROTEIN, HUMAN; SMAD PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL CYCLE ARREST; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE; SURVIVAL TIME; TUMOR GROWTH; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; CANCER INVASION; CELL MOTION; DRUG ANTAGONISM; FEMALE; LUNG TUMOR; METASTASIS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL MOVEMENT; DNA-BINDING PROTEINS; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 70249098042     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp154     Document Type: Article

References (43)

1. Li,Y. et al. (1986) Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene. J. Virol., 57, 1065-1072.
2. Akiyoshi,S. et al. (1999) c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J. Biol. Chem., 274, 35269-35277.
3. Luo,K. et al. (1999) The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes. Dev., 13, 2196-2206.
4. Sun,Y. et al. (1999) Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol. Cell, 4, 499-509.
5. Xu,W. et al. (2000) Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor. Proc. Natl Acad. Sci. USA, 97, 5924-5929.
6. Reed,J.A. et al. (2001) Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: Functional implications for transforming growth factor beta signaling. Cancer Res., 61, 8074-8078.
7. Fukuchi,M. et al. (2004) Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. Int. J. Cancer, 108, 818-824.
8. Buess,M. et al. (2004) Amplification of SKI is a prognostic marker in early colorectal cancer. Neoplasia, 6, 207-212.
9. Heider,T.R. et al. (2007) Ski promotes tumor growth through abrogation of transforming growth factor-beta signaling in pancreatic cancer. Ann. Surg., 246, 61-68.
10. Ritter,M. et al. (2006) Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia, 20, 437-443.
11. Jemal,A. et al. (2008) Cancer statistics, 2008. CA Cancer J. Clin., 58, 71-96.
12. Goggins,M. et al. (1998) Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res., 58, 5329-5332.
13. Jonson,T. et al. (1999) Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer. Genes Chromosomes Cancer, 24, 62-71.
14. Villanueva,A. et al. (1998) Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells. Oncogene, 17, 1969-1978.
15. Friess,H. et al. (1993) Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology, 105, 1846-1856.
16. Nicolas,F.J. et al. (2003) Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene, 22, 3698-3711.
17. Subramanian,G. et al. (2004) Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res., 64, 5200-5211.
18. Rowland-Goldsmith,M.A. et al. (2001) Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation. Clin. Cancer Res., 7, 2931-2940.
19. Gaspar,N.J. et al. (2007) Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. Mol. Pharmacol., 72, 152-161.
20. Teraoka,H. et al. (2001) TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. Int. J. Oncol., 19, 709-715.
21. Tian,F. et al. (2003) Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res., 63, 8284-8292.
22. Schniewind,B. et al. (2007) Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function. Oncogene, 26, 4850-4862.
23. Weinel,R.J. et al. (1992) Expression and function of VLA-alpha 2, -alpha 3, -alpha 5 and -alpha 6-integrin receptors in pancreatic carcinoma. Int. J. Cancer, 52, 827-833.
24. Michl,P. et al. (2005) CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell, 7, 521-532.
25. Azuma,H. et al. (2005) Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J. Natl Cancer Inst., 97, 1734-1746.
26. Lekanne Deprez,R.H. et al. (2002) Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions. Anal. Biochem., 307, 63-69.
27. Takahashi,H. et al. (2004) Biologically different subgroups of invasive ductal carcinoma of the pancreas: Dpc4 status according to the ratio of intraductal carcinoma components. Clin. Cancer Res., 10, 3772-3779.
28. Le Scolan,E. et al. (2008) Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res., 68, 3277-3285.
29. Hahn,S.A. et al. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 271, 350-353.
30. Ijichi,H. et al. (2001) Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells. Biochem. Biophys. Res. Commun., 289, 350-357.
31. Ijichi,H. et al. (2004) Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. Oncogene, 23, 1043-1051.
32. Moustakas,A. et al. (2005) Non-Smad TGF-beta signals. J. Cell Sci., 118, 3573-3584.
33. Deckers,M. et al. (2006) The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 66, 2202-2209.
34. Kang,Y. et al. (2005) Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl Acad. Sci. USA, 102, 13909-13914.
35. Tian,F. et al. (2004) Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res. 64, 4523-4530.
36. Jonson,T. et al. (2001) Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas. Int. J. Oncol. 19, 71-81.
37. Massague,J. (2004) G1 cell-cycle control and cancer. Nature, 432, 298-306.
38. Leivonen,S.K. et al. (2006) Activation of Smad signaling enhances collagenase- 3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene, 25, 2588-2600.
39. Javelaud,D. et al. (2005) Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene, 24, 7624-7629.
40. Ellenrieder,V. et al. (2001) TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system. Int. J. Cancer, 93 204-211.
41. Nakajima,S. et al. (2004) N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin. Cancer Res., 10, 4125-4133.
42. Jungert,K. et al. (2007) Sp1 is required for transforming growth factor-betainduced mesenchymal transition and migration in pancreatic cancer cells. Cancer Res., 67, 1563-1570.
43. Pardali,K. et al. (2007) Actions of TGF-beta as tumor suppressor and prometastatic factor in human cancer. Biochim. Biophys. Acta, 1775, 21-62.