Ascl1 converts dorsal midbrain astrocytes into functional neurons In Vivo

Journal of Neuroscience

Volumn 35, Issue 25, 2015, Pages 9336-9355

  Liu, Yueguang ^a   Miao, Qinglong ^a,b,c   Yuan, Jiacheng ^a   Han, Su’e ^a,c   Zhang, Panpan ^a,c   Li, Sanlan ^a,c   Rao, Zhiping ^a,c   Zhao, Wenlong ^a,c   Ye, Qian ^b   Geng, Junlan ^a   Zhang, Xiaohui ^b   Cheng, Leping ^a,c  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Astrocyte to neuron conversion in vivo; Cell fate determination; Induced neuronal (iN) cells; Proneural gene Ascl1; Transdifferentiation

Indexed keywords

AFIMOXIFENE; BETA TUBULIN; BROXURIDINE; MICROTUBULE ASSOCIATED PROTEIN 2; NEURON SPECIFIC NUCLEAR PROTEIN; PARVOVIRUS VECTOR; TAMOXIFEN; TRANSCRIPTION FACTOR MASH1; ASCL1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; ASTROCYTE; CONTROLLED STUDY; CORPUS STRIATUM; ELECTROPHYSIOLOGICAL PROCEDURES; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; MESENCEPHALON; MOUSE; NERVE CELL; NEUROSPHERE ASSAY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATOSENSORY CORTEX; VIRAL GENE DELIVERY SYSTEM; VOLTAGE CLAMP TECHNIQUE; ANIMAL; CELL CULTURE; CELL TRANSDIFFERENTIATION; CYTOLOGY; DEPENDOPARVOVIRUS; GENE TRANSFER; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; METABOLISM; MUTANT MOUSE STRAIN; ORGAN CULTURE TECHNIQUE; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ASTROCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DEPENDOVIRUS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MICE; MICE, MUTANT STRAINS; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; REAL-TIME POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC;

EID: 84933557853     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3975-14.2015     Document Type: Article

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