Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin

ACS Chemical Biology

Volumn 12, Issue 12, 2017, Pages 3093-3102

  Adnani, Navid ^a   Chevrette, Marc G ^a   Adibhatla, Srikar N ^a   Zhang, Fan ^a   Yu, Qing ^a   Braun, Doug R ^a   Nelson, Justin ^b   Simpkins, Scott W ^b   McDonald, Bradon R ^a   Myers, Chad L ^b   Piotrowski, Jeff S ^c   Thompson, Christopher J ^d   Currie, Cameron R ^a   Li, Lingjun ^a   Rajski, Scott R ^a   Bugni, Tim S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Yumanity Therapeutics   (United States)

^d BRUKER DALTONIK GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; KEYICIN; NOGALAMYCIN; UNCLASSIFIED DRUG; ANTHRACYCLINE; ANTIINFECTIVE AGENT; OLIGOSACCHARIDE;

ARTICLE; BACTERIUM; BIOSYNTHESIS; COCULTURE; DRUG MECHANISM; DRUG STRUCTURE; ESCHERICHIA COLI; GENOME; GENOMICS; MARINE INVERTEBRATE; MASS SPECTROMETRY; MICROMONOSPORA; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RHODOCOCCUS; ANIMAL; AQUATIC SPECIES; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; INVERTEBRATE; METABOLISM; METABOLOMICS; MICROBIOLOGY;

ANIMALS; ANTHRACYCLINES; ANTI-BACTERIAL AGENTS; AQUATIC ORGANISMS; COCULTURE TECHNIQUES; COMPUTATIONAL BIOLOGY; INVERTEBRATES; METABOLOMICS; MICROMONOSPORA; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; RHODOCOCCUS;

EID: 85038561644     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.7b00688     Document Type: Article

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