Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 19, 2016, Pages 5251-5256

  Siitonen, Vilja ^a   Selvaraj, Brinda ^b   Niiranen, Laila ^a   Lindqvist, Ylva ^b   Schneider, Gunter ^b   Metsä Ketelä, Mikko ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Crystal structure; Iron dependent oxygenase; Natural product biosynthesis; Streptomyces; ketoglutarate dependent oxygenase

Indexed keywords

2 OXOGLUTARIC ACID; AMINOSUGAR; ANTHRACYCLINE; CARBON; ENZYME; IRON; NOGALAMYCIN; ALPHA-KETOGLUTARIC ACID; BACTERIAL PROTEIN; HEME; MULTIENZYME COMPLEX; OXYGENASE;

ARCHITECTURE; ARTICLE; ATOM; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; EPIMERIZATION; NONHUMAN; PRIORITY JOURNAL; SPECIES; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; GENETIC VARIATION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; STREPTOMYCES;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BIOSYNTHETIC PATHWAYS; EVOLUTION, MOLECULAR; GENETIC VARIATION; HEME; IRON; KETOGLUTARIC ACIDS; MODELS, GENETIC; MULTIENZYME COMPLEXES; NOGALAMYCIN; OXYGENASES; STREPTOMYCES;

EID: 84966340095     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1525034113     Document Type: Article

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