Developmental neurotoxicants disrupt activity in cortical networks on microelectrode arrays: Results of screening 86 compounds during neural network formation

Toxicological Sciences

Volumn 160, Issue 1, 2017, Pages 121-135

  Frank, Christopher L ^a   Brown, Jasmine P ^a   Wallace, Kathleen ^a   Mundy, William R ^a   Shafer, Timothy J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cell culture; Developmental; In vitro and alternatives; Microelectrode array; Neurotoxicity; Neurotoxicology; Screening

Indexed keywords

LACTATE DEHYDROGENASE; NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BRAIN CORTEX; CELL METABOLISM; CELL VIABILITY; EC50; HAZARD; IN VITRO STUDY; IN VIVO STUDY; MACHINE LEARNING; MICROARRAY ANALYSIS; MICROELECTRODE ARRAY; NERVE CELL NETWORK; NEUROTOXICITY; NONHUMAN; RAT; SCREENING; ACTION POTENTIAL; ANIMAL; CELL CULTURE; CELL SURVIVAL; CLASSIFICATION; DEVICES; DOSE RESPONSE; DRUG EFFECT; ENERGY METABOLISM; GROWTH, DEVELOPMENT AND AGING; LONG EVANS RAT; METABOLISM; MICROELECTRODE; NEWBORN; PATHOPHYSIOLOGY; POLLUTANT; RISK ASSESSMENT; TIME FACTOR; TOXICITY; TOXICITY AND INTOXICATION; TOXICITY TESTING;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; ENVIRONMENTAL POLLUTANTS; MACHINE LEARNING; MICROELECTRODES; NERVE NET; NEUROTOXICITY SYNDROMES; RATS, LONG-EVANS; RISK ASSESSMENT; TIME FACTORS; TOXICITY TESTS;

EID: 85038023243     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfx169     Document Type: Article

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