Antiepileptic drugs and neurodevelopment

Current Neurology and Neuroscience Reports

Volumn 6, Issue 4, 2006, Pages 341-346

  Motamedi, Gholam K ^a   Meador, Kimford J ^b  

^a GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; DIAZEPAM; GABAPENTIN; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

AORTA COARCTATION; APOPTOSIS; ATTENTION DEFICIT DISORDER; AUTISM; AWARENESS; BEHAVIOR DISORDER; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CARDIOVASCULAR MALFORMATION; CLEFT LIP PALATE; COGNITIVE DEFECT; COHORT ANALYSIS; CONGENITAL MALFORMATION; CRANIOFACIAL MALFORMATION; EVIDENCE BASED MEDICINE; FALLOT TETRALOGY; HEART ATRIUM SEPTUM DEFECT; HUMAN; LONG TERM EXPOSURE; NEURAL TUBE DEFECT; NEUROTOXICITY; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PULMONARY VALVE STENOSIS; REVIEW; RISK ASSESSMENT; TERATOGENICITY; THIRD TRIMESTER PREGNANCY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTICONVULSANTS; BRAIN; EPILEPSY; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; TERATOGENS;

EID: 33746040103     PISSN: 15284042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11910-006-0028-5     Document Type: Review

References (48)

1. Perucca E: Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neurol 2005, 4:781-786.
2. Hallak M, Kupsky WJ, Hotra JW, et al.: Fetal rat brain damage caused by maternal seizure activity: prevention by magnesium sulfate. Am J Obstet Gynecol 1999, 181:828-834.
3. Nei M, Daly S, Liporace J: A maternal complex partial seizure in labor can affect fetal heart rate. Neurology 1998, 51:904-906.
4. Meador KJ, Zupanc ML: Neurodevelopmental outcomes of children born to mothers with epilepsy. Cleve Clin J Med 2004, 71(Suppl 2):S38-S41.
5. ACOG educational bulletin: Seizure disorders in pregnancy. Number 231, December 1996. Committee on Educational Bulletins of the American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 1997, 56:279-286.
6. Motamedi G, Meador K: Epilepsy and cognition. Epilepsy Behav 2003, 4(Suppl 2):S25-S38.
7. Meador KJ: Cognitive effects of epilepsy and antiepileptic medications. In The Treatment of Epilepsy: Principles & Practice. Philadelphia: Lippincott Williams & Willkins; 2001:1215-1225.
8. Meador KJ: Cognitive side effects of antiepileptic drugs. Can J Neurol Sci 1994, 21:S12-S16.
9. Holmes LB, Harvey EA, Coull BA, et al.: The teratogenicity of anticonvulsant drugs. N Engl J Med 2001, 344:1132-1138.
10. Olafsson E, Hallgrimsson JT, Hauser WA, et al.: Pregnancies of women with epilepsy: a population-based study in Iceland. Epilepsia 1998, 39:887-892.
11. Bittigau P, Sifringer M, Genz K, et al.: Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A 2002, 99:15089-15094.
12. Adab N, Kini U, Vinten J, et al.: The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 2004, 75:1575-1583.
13. Hanson JW, Smith DW: The fetal hydantoin syndrome. J Pediatr 1975, 87:285-290.
14. Nakane Y, Okuma T, Takahashi R, et al.: Multi-institutional study on the teratogenicity and fetal toxicity of antiepileptic drugs: a report of a collaborative study group in Japan. Epilepsia 1980, 21:663-680.
15. Lindhout D, Omtzigt JG: Pregnancy and the risk of teratogenicity. Epilepsia 1992, 33 (Suppl 4):S41-S48.
16. Laegreid L, Hagberg G, Lundberg A: Neurodevelopment in late infancy after prenatal exposure to benzodiazepines - a prospective study. Neuropediatrics 1992, 23:60-67.
17. Samren EB, van Duijn CM, Koch S, et al.: Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia 1997, 38:981-990.
18. Holmes LB, Wyszynski DF, Lieberman E: The AED (anti-epileptic drug) pregnancy registry: a 6-year experience. Arch Neurol 2004, 61:673-678.
19. Wyszynski DF, Nambisan M, Surve T, et al.: Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 2005, 64:961-965.
20. Vajda FJ, O'brien TJ, Hitchcock A, et al.: Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 2004, 11:854-858.
21. Morrow J, Russell A, Guthrie E, et al.: Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006, 77:193-198.
22. Wide K, Winbladh B, Kallen B: Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 2004, 93:174-176.
23. Artama M, Auvinen A, Raudaskoski R, et al.: Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 2005, 64:1874-1878.
24. Meador KJ, Baker GA, Finnell RH, et al.; NEAD Study Group: In utero antiepileptic drug exposure: fetal death and malformations. Neurology 2006, In press.
25. Meador KJ: Neurodevelopmental effects of antiepileptic drugs. Curr Neurol Neurosci Rep 2002, 2:373-378.
26. Vanoverloop D, Schnell RR, Harvey EA, et al.: The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function at 4 to 8 years of age. Neurotoxicol Teratol 1992, 14:329-335.
27. Viggedal G, Hagberg BS, Laegreid R, et al.: Mental development in late infancy after prenatal exposure to benzodiazepines - a prospective study. J Child Psychol Psychiatry 1993, 34:295-305.
28. Scolnik D, Nulman I, Rovet J, et al.: Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. JAMA 1994, 271:767-770.
29. Loring DW, Meador KJ, Thompson WO: Neurodevelopment after in utero exposure to phenytoin and carbamazepine. JAMA 1994, 272:850-851.
30. Reinisch JM, Sanders SA, Mortensen EL, et al.: In utero exposure to phenobarbital and intelligence deficits in adult men. JAMA 1995, 274:1518-1525.
31. Dean JC, Hailey H, Moore SJ, et al.: Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth. J Med Genet 2002, 39:251-259.
32. Mawer G, Clayton-Smith J, Coyle H, et al.: Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate. Seizure 2002, 11:512-518.
33. Adab N, Jacoby A, Smith, D, et al.: Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 2001, 70:15-21.
34. Vinten J, Adab N, Kini U, et al.: Neuropsychological effects of exposure to anticonvulsant medication in utero. Neurology 2005, 64:949-954.
35. Gaily E, Kantola-Sorsa E, Hiilesmaa V, et al.: Normal intelligence in children with prenatal exposure to carbamazepine. Neurology 2004, 62:28-32.
36. Palmieri C, Canger R: Teratogenic potential of the newer antiepileptic drugs: what is known and how should this influence prescribing? CNS Drugs 2002, 16:755-764.
37. Costa LG, Steardo L, Cuomo V: Structural effects and neurofunctional sequelae of developmental exposure to psychotherapeutic drugs: experimental and clinical aspects. Pharmacol Rev 2004, 56:103-147.
38. Cunnington M, Tennis P: Lamotrigine and the risk of malformations in pregnancy. Neurology 2005, 64:955-960.
39. Koren G, Pastuszak A, Ito S: Drugs in pregnancy. N Engl J Med 1998, 338:1128-1137.
40. Marchi NS, Azoubel R, Tognola WA: Teratogenic effects of lamotrigine on rat fetal brain: a morphometric study. Arq Neuropsiquiatr 2001, 59:362-364.
41. Frieder B, Epstein S, Grimm VE: The effects of exposure to diazepam during various stages of gestation or during lactation on the development and behavior of rat pups. Psychopharmacology (Berl) 1984, 83:51-55.
42. Schaefer GB, Sheth RD, Bodensteiner JB: Cerebral dysgenesis. An overview. Neurol Clin 1994, 12:773-788.
43. Glier C, Dzietko M, Bittigau P, et al.: Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 2004, 187:403-409.
44. Manthey D, Asimiadou S, Stefovska V, et al.: Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol 2005, 193:497-503.
45. Kim J, Lapides D, Kondratyev A, Gale K: Repeated brief seizures in neonatal rats attenuate programmed cell death induced by MK801 (Abstract). Epilepsia 2004, 45 (Suppl 7):209.
46. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Epilepsia 1998, 39:1226-1231.
47. Rosser EM, Wilson LC: Drugs for epilepsy have teratogenic risks. BMJ 1999, 318:1289.
48. Perucca E: Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neurol 2005, 4:781-786.