Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Nature Materials

Volumn 16, Issue 11, 2017, Pages 1112-1119

  Cruz, Nelly M ^a,b   Song, Xuewen ^c,d   Czerniecki, Stefan M ^a,b   Gulieva, Ramila E ^a,b   Churchill, Angela J ^a,b   Kim, Yong Kyun ^a,b   Winston, Kosuke ^a,b   Tran, Linh M ^a,b   Diaz, Marco A ^a,b   Fu, Hongxia ^b   Finn, Laura S ^b,e   Pei, York ^c,d   Himmelfarb, Jonathan ^a,b   Freedman, Benjamin S ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DEFECTS; STEM CELLS;

CELLULAR MODEL; CYCLIC ADENOSINE MONOPHOSPHATE (CAMP); FLUID-FILLED; GENETIC MODELS; MICROENVIRONMENTS; PHYSICAL COMPONENTS; PLURIPOTENT STEM CELLS; POLYCYSTIC KIDNEY DISEASE;

HUMAN FORM MODELS;

CYCLIC AMP; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN; POLYCYSTIN;

BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KIDNEY POLYCYSTIC DISEASE; METABOLISM; ORGANOID; PATHOLOGY; TUMOR MICROENVIRONMENT;

CELL LINE; CELLULAR MICROENVIRONMENT; CYCLIC AMP; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; ORGANOIDS; POLYCYSTIC KIDNEY DISEASES; TRPP CATION CHANNELS;

EID: 85037734904     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/NMAT4994     Document Type: Letter

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